A5028015175- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Genetics and Neurodevelopmental Disorders
- Herpesvirus Infections and Treatments
- Neuroendocrine Tumor Research Advances
- Chemokine receptors and signaling
- Myasthenia Gravis and Thymoma
- Chronic Lymphocytic Leukemia Research
- RNA regulation and disease
- Genetic Neurodegenerative Diseases
- Glycosylation and Glycoproteins Research
Erasmus MC
2016-2023
Amsterdam Neuroscience
2023
Amsterdam UMC Location Vrije Universiteit Amsterdam
2023
Vrije Universiteit Amsterdam
2023
Leiden University
2023
Medisch Centrum Haaglanden
2023
ERN RITA
2020
ERN GUARD-Heart
2020
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2020
Stichting Epilepsie Instellingen Nederland
2016
<h3>Objective</h3> Antibodies against glutamic acid decarboxylase 65 (anti-GAD65) are associated with a number of neurologic syndromes. However, their pathogenic role is controversial. Our objective was to describe clinical and paraclinical characteristics anti-GAD65 patients analyze response immunotherapy. <h3>Methods</h3> Retrospectively, we studied (n = 56) positive any symptom. We tested serum CSF ELISA, immunohistochemistry, cell-based assay. Accordingly, set cutoff value 10,000 IU/mL...
To assess the clinical relevance of a positive voltage-gated potassium channel (VGKC) test in patients lacking antibodies to LGI1 and Caspr2.VGKC-positive were tested for Caspr2 antibodies. Patients both matched (1:2) VGKC-negative patients. Clinical paraclinical criteria used blindly determine evidence autoimmune inflammation groups. with an inconclusive VGKC titer analyzed same way.A total 1,455 by radioimmunoassay. Fifty-six positive, 50 whom available be included. Twenty-five had (n =...
In this study we report the clinical features of 32 patients with gamma aminobutyric acid B receptor (GABABR) antibodies, identify additional autoantibodies in anti-GABABR encephalitis that mark presence an underlying small cell lung carcinoma and optimize laboratory methods for detection GABABR antibodies. Patients (n = 3225) were tested antibodies using cell-based assay, immunohistochemistry live hippocampal neurons. Clinical data obtained retrospectively. Potassium channel tetramerization...
The clinical criteria for autoimmune encephalitis (AE) were proposed by Graus et al. in 2016. In this study, the AE validated real world, and common mimics described. addition, probable anti-LGI1 validated.
Abstract Anti-Leucine-rich glioma inactivated-1 (LGI1) and anti-contactin-associated-protein-2 (CASPR2) autoimmune encephalitis (AIE) are common characterized by pathogenic antibodies targeting neuronal autoantigens. However, the drivers of antibody-secreting cells (ASC) involvement T remain unresolved. We performed single cell RNA-sequencing fresh cerebrospinal fluid (CSF) parallel blood samples 15 patients with LGI1- (n=9) CASPR2-AIE (n=6) compared to control (multiple sclerosis (MS) n=15,...
Autoimmune encephalitis (AIE) may present with prominent cognitive disturbances without overt inflammatory changes in MRI and CSF. Identification of these neurodegenerative dementia diagnosis mimics is important because patients generally respond to immunotherapy. The objective this study was determine the frequency neuronal antibodies presumed describe clinical characteristics antibodies.In retrospective cohort study, 920 were included from established cohorts at 2 large Dutch academic...
Autoimmune encephalitis (AIE) and paraneoplastic neurologic syndromes (PNSs) encompass a heterogeneous group of antibody-associated disorders. Both the number commercially available antibody tests have increased considerably over past decade. High-quality population-based data on epidemiology these disorders real-world performance are needed.
Background The aim of this study was to determine treatment response and whether it is associated with antibody titre change in patients autoimmune nodopathy (AN) previously diagnosed as chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), compare clinical features between AN CIDP. Methods Serum IgG antibodies neurofascin-155 (NF155), contactin-1 (CNTN1) contactin-associated protein 1 (CASPR1) were detected cell-based assays Clinical improvement determined using the modified...