A5027657451- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Balance, Gait, and Falls Prevention
- Venous Thromboembolism Diagnosis and Management
- Health Systems, Economic Evaluations, Quality of Life
- Clinical practice guidelines implementation
- Trauma and Emergency Care Studies
- Emergency and Acute Care Studies
- Healthcare Systems and Practices
- Healthcare Policy and Management
- Fluorine in Organic Chemistry
- Salivary Gland Disorders and Functions
- Cerebral Palsy and Movement Disorders
- Simulation-Based Education in Healthcare
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Global Health Care Issues
- HIV/AIDS drug development and treatment
- Chronic Disease Management Strategies
- Synthesis and Catalytic Reactions
- Diabetic Foot Ulcer Assessment and Management
- Infectious Aortic and Vascular Conditions
- Head and Neck Cancer Studies
- Context-Aware Activity Recognition Systems
- Interprofessional Education and Collaboration
Northumbria University
2016-2025
ORCID
2024
Birthingway College of Midwifery
2023
Newcastle University
2010-2020
University of Glasgow
2019-2020
University of Oxford
2015
Musgrove Park Hospital
2014
University College London
2014
NIHR Leeds Musculoskeletal Biomedical Research Unit
2014
Newcastle upon Tyne Hospitals NHS Foundation Trust
2014
Background Falls cause fear, anxiety and loss of confidence, resulting in activity avoidance, social isolation increasing frailty. The umbrella term for these problems is ‘fear falling’, seen up to 85% older adults who fall. Evidence effectiveness physical psychological interventions limited, with no previous studies examining the role an individually delivered cognitive–behavioural therapy (CBT) approach. Objectives Primary objective To develop then determine a new CBT intervention (CBTi)...
This paper presents an overview and comparative analysis of the epidemiological situation policy responses in France, Belgium, Canada during early stages 2020 Covid-19 pandemic (Feb.-Aug. 2020). These three countries are compared because they represent a spectrum different governance structures while also being OECD nations that similar many other respects.A rapid review primary data from was conducted. Data collected official government documents whenever possible, supplemented by...
Endovascular thrombectomy is a highly effective treatment for acute ischemic stroke due to large arterial occlusion. Routine provision will require major changes in service configuration and workforce. An important first step quantify the population of patients that could benefit. We estimated annual UK suitable endovascular using standard or advanced imaging patient selection.Evidence from randomised control trials national registries was combined estimate incidence define decision-tree...
Heterogeneity is a major obstacle to developing effective treatments for patients with primary Sjögren's syndrome. We aimed develop robust method stratification, exploiting heterogeneity in patient-reported symptoms, and relate these differences pathobiology therapeutic response.
Aims The primary aim is to estimate the current and potential number of patients on NHS England orthopaedic elective waiting lists by November 2020. secondary aims are model recovery strategies; review deficit hip knee arthroplasty from National Joint Registry (NJR) data; assess cost returning pre-COVID-19 list numbers. Methods A referral, list, eventual surgery was created calibrated using historical data (April 2017 March 2020) used investigate possible consequences unmet demand resulting...
<title>Abstract</title> Background Mobile Stroke Units (MSUs) have been shown to be an effective means improve outcomes following stroke by increasing the rate and speed of thrombolysis. The consequences MSU implementation in UK’s National Health Service not examined but is important because contextual geographical organisational dependencies may influence effectiveness, cost-effectiveness, equality access. We aimed develop a model explore these issues across ten English NHS Ambulance...
EuroQoL-5 dimension (EQ-5D) is a standardised preference-based tool for measurement of health-related quality life and EQ-5D utility values can be converted to quality-adjusted years (QALYs) aid cost-utility analysis. This study aimed evaluate the 639 patients with primary Sjögren's syndrome (PSS) in UK.Prospective data collected using pro forma were compared UK normative data. Relationships between clinical laboratory features PSS explored.The proportion reporting any problem mobility,...
Fall risk assessment needs contemporary approaches based on habitual data. Currently, inertial measurement unit (IMU)-based wearables are used to inform free-living spatio-temporal gait characteristics mobility assessment. Typically, a fluctuation of those will infer an increased fall risk. However, current with IMUs alone remain limited, as there no contextual data comprehensively determine if underlying mechanistic (intrinsic) or environmental (extrinsic) factors impact and, therefore,...
Objectives: Foot orthoses are commonly prescribed as an intervention for people with rheumatoid arthritis (RA). Data relating to the cost-effectiveness of foot in RA limited. The aim was evaluate clinical and two types established RA.Method: A single-blind randomized controlled trial undertaken compare custom-made (CMFOs) simple insoles (SIs) 41 RA. Function Index (FFI) used measure pain, disability, functional limitation. Costs were estimated from perspective UK National Health Service...
The effect of temperature, solvent, and type aldehyde on the stereospecific or stereoselective formation azomethine ylides by decarboxylative condensation aldehydes with three types α-amino acids, (i) cyclic secondary (ii) acids a benzylic carboxy group, (iii) acyclic primary has been studied. Stereospecific anti-dipole in temperature dependent is inferred from stereochemistry cycloadducts N-methylmaleimide. These results are used to support mechanistic scheme involving loss carbon dioxide...
Evidence is presented that indicates the decarboxylative route to azomethine ylides from both primary and secondary, cyclic acyclic, α-amino acids involves an intermediate oxazolidin-5-one which loses carbon dioxide in a 1,3-dipolar cycloreversion reaction generate ylide stereospecifically.
Thrombolytic treatment for acute ischaemic stroke improves prognosis, although there is a risk of bleeding complications leading to early death/severe disability. Benefit from thrombolysis time dependent and must be administered within 4.5 hours onset symptoms, which presents unique challenges development tools support decision making patient understanding about treatment. Our aim was develop aid patient-specific clinical decision-making stroke, communication personalised information on...
The purpose of this study was to use time trade-off assess the factors influencing patients' decisions in advanced laryngeal cancer. Time is a well-established method assessing how individuals value particular health state.We developed vignettes depicting life after chemoradiotherapy or laryngectomy. One hundred fourteen participants ranked them, assigned utility values, and rated importance survival on treatment choice.Chemoradiotherapy preferred by 62% laryngectomy 38%. Chemoradiotherapy...
Background Many glaucoma referrals from the community to hospital eye services are unnecessary. Imaging technologies can potentially be useful triage this population. Objectives To assess diagnostic performance and cost-effectiveness of imaging as tests for identifying people with glaucoma. Design Within-patient comparative accuracy study. Markov economic model comparing a test usual care. Setting Secondary Participants Adults referred possible Interventions Heidelberg Retinal Tomography...
Primary Sjögren's syndrome (pSS) is a chronic inflammatory condition, which presents with symptoms of dryness, pain, fatigue and often anxiety depression. Health-related quality life (HRQoL) significantly reduced in pSS the direct indirect health costs are substantial. This study aims to determine how symptom burden, disease activity demographics associate HRQoL longitudinally over median 24-month follow-up period pSS.
Background Evidence for Mobile Stroke Units (MSUs) demonstrates that onset to treatment times intravenous thrombolysis can be reduced and access mechanical thrombectomy might improved. Despite growing use of MSUs internationally, date there have been no studies in NHS England Wales exploring the acceptability clinicians, patient public representatives other key stakeholders, which are important when considering potential feasibility implementation. Methods This study used a mixed methods...
Purpose Both intravenous thrombolysis (IVT) and intra-arterial endovascular thrombectomy (ET) improve the outcome of patients with acute ischaemic stroke, being an option for those large vessel occlusions. We sought to understand how organisation services affects time treatment both thrombectomy. Method A multi-objective optimisation approach was used explore relationship between number centres times treatment. The analysis is based on 238,887 emergency stroke admissions in England over 3...