A5007355607- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Knee injuries and reconstruction techniques
- Hip and Femur Fractures
- Lower Extremity Biomechanics and Pathologies
- Osteoarthritis Treatment and Mechanisms
- Shoulder Injury and Treatment
- Sports injuries and prevention
- Hip disorders and treatments
- Mitochondrial Function and Pathology
- Orthopedic Surgery and Rehabilitation
- Cancer-related molecular mechanisms research
- Cardiac, Anesthesia and Surgical Outcomes
- Cytokine Signaling Pathways and Interactions
- Autoimmune and Inflammatory Disorders Research
- Growth Hormone and Insulin-like Growth Factors
- Bone health and osteoporosis research
- Pelvic and Acetabular Injuries
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 and healthcare impacts
- RNA modifications and cancer
- Bone fractures and treatments
- Adolescent and Pediatric Healthcare
- Immune Cell Function and Interaction
Newcastle upon Tyne Hospitals NHS Foundation Trust
2015-2025
Freeman Hospital
2016-2025
Edinburgh Royal Infirmary
2020-2025
Newcastle University
2015-2024
University Teaching Hospital
2024
University of Newcastle Australia
2009-2024
Centre for Life
2013-2024
Newcastle upon Tyne Hospital
2009-2023
Bridge University
2023
Wellcome Centre for Mitochondrial Research
2018-2022
Mammalian cells contain thousands of copies mitochondrial DNA (mtDNA). At birth, these are thought to be identical in most humans. Here, we use long read length ultra-deep resequencing-by-synthesis interrogate regions the mtDNA genome from related and unrelated individuals at unprecedented resolution. We show that very low-level heteroplasmic variance is present all tested healthy individuals, likely due both inherited somatic single base substitutions. Using this approach, demonstrate an...
The WOMAC score is a validated outcome measure for use in patients undergoing TKA. Defining meaningful changes the important sample-size calculations clinical research and interpreting published studies. However, inconsistencies among studies regarding key definitions after TKA potentially could result incorrectly powered misinterpretation of results.(1) To identify minimum clinically difference (MCID) total its components 1 year using an anchor-based methodology. (2) define change (MIC)...
Genetic and biochemical defects of mitochondrial function are a major cause human disease, but their link to morphology in situ has not been defined. Here, we develop quantitative three-dimensional approach map network organization muscle at electron microscopy resolution. We establish morphological differences between mouse among patients with DNA (mtDNA) diseases compared healthy controls. also define the ultrastructure prevalence nanotunnels, which exist as either free-ended or connecting...
The pathogenesis of declining bone mineral density, a universal feature ageing, is not fully understood. Somatic mitochondrial DNA (mtDNA) mutations accumulate with age in human tissues and mounting evidence suggests that they may be integral to the ageing process. To explore potential effects mtDNA on biology, we compared microarchitecture turnover an series wild type mice PolgAmut/mut 'mutator' mouse. In vivo analyses showed age-related loss both groups mice; however, it was significantly...
Aims The aim of this study was to assess the quality life patients on waiting list for a total hip (THA) or knee arthroplasty (KA) during COVID-19 pandemic. Secondary aims were whether length time influenced and rate deferral surgery. Methods During period (August September 2020) 843 (THA n = 394, KA 449) from ten centres in UK reported their EuroQol five dimension (EQ-5D) scores completed questionnaire (2020 group). Patient demographic details, procedure, date when listed recorded. Patients...
Background The choice of graft material for anterior cruciate ligament reconstruction is believed to play a major role in outcome, but most comparisons have not been well controlled. Hypothesis (patellar tendon or hamstring tendon) does affect clinical outcome after reconstruction. Study Design Prospective, nonrandomized trial. Methods Two groups 90 patients each were followed minimum 5 years. Results International Knee Documentation Committee assessment revealed that more than 85% group had...
Background: Revision rates following unicondylar knee replacement vary among reporting institutions. from institutions involved in the design of these implants and independent single-center series are comparable with those total replacement, suggesting that higher operative volumes surgical enthusiasm improve revision outcomes. Methods: This registry-based cohort study analysis 23,400 medial cemented Oxford replacements for treatment osteoarthritis. Total center surgeon were calculated over...
An incorrect femoral tunnel position or inappropriate graft tensioning during medial patellofemoral ligament (MPFL) reconstruction may cause altered joint kinematics and contact mechanics, potentially resulting in pain degeneration.Nonanatomic positioning of the overtensioning MPFL will have an adverse effect on patellar tracking mechanics.Controlled laboratory study.Eight fresh-frozen cadaveric knees were placed a customized testing rig, with femur fixed tibia mobile through 90° flexion....
In the United Kingdom, organizations involved in health-care commissioning have recently introduced legislation limiting access to total knee arthroplasty through introduction of arbitrary thresholds unsupported by literature and based on body mass index. This study aimed establish relationship between index patient-reported specific general outcomes arthroplasty.Using national outcome measures (PROMs) linked National Joint Registry, we identified 13,673 primary arthroplasties performed for...
Patient-reported outcome measures (PROMs) are increasingly being used to assess functional and patient satisfaction. They provide a framework for comparisons between surgical units, individual surgeons benchmarking financial remuneration. Better performance may bring the reward of more customers as patients commissioners seek out high performers their elective procedures. Using National Joint Registry (NJR) data linked PROMs we identified 22 691 primary total knee replacements (TKRs)...
Pre-operative variables are increasingly being used to determine eligibility for total knee replacement (TKR). This study was undertaken evaluate the relationships, interactions and predictive capacity of available pre- post-operatively on patient satisfaction following TKR. Using nationally collected reported outcome measures data from National Joint Registry England Wales, we identified 22 798 patients who underwent TKR osteoarthritis between August 2008 September 2010. The ability...
Aims The aim of this consensus was to develop a definition post-operative fibrosis the knee. Patients and Methods An international panel experts took part in formal process composed discussion phase three Delphi rounds. Results Post-operative knee defined as limited range movement (ROM) flexion and/or extension, that is not attributable an osseous or prosthetic block from malaligned, malpositioned incorrectly sized components, metal hardware, ligament reconstruction, infection (septic...
Aims The primary aim of this study was to assess whether patient satisfaction one year after total knee arthroplasty (TKA) changed with longer follow-up. secondary aims were identify predictors at year, persistence dissatisfaction, and late onset dissatisfaction in patients that originally satisfied year. Patients Methods A retrospective cohort consisting 1369 undergoing a TKA for osteoarthritis had not undergone revision identified from an established database. Patient demographics,...
Aims The primary aim is to estimate the current and potential number of patients on NHS England orthopaedic elective waiting lists by November 2020. secondary aims are model recovery strategies; review deficit hip knee arthroplasty from National Joint Registry (NJR) data; assess cost returning pre-COVID-19 list numbers. Methods A referral, list, eventual surgery was created calibrated using historical data (April 2017 March 2020) used investigate possible consequences unmet demand resulting...
Aims The primary aim was to assess whether robotic total knee arthroplasty (rTKA) had a greater early knee-specific outcome when compared manual TKA (mTKA). Secondary aims were rTKA associated with improved expectation fulfilment, health-related quality of life (HRQoL), and patient satisfaction mTKA. Methods A randomized controlled trial undertaken, patients either mTKA or rTKA. objective functional improvement at six months. Overall, 100 randomized, 50 each group, whom 46 41 available for...
The aim was to assess whether robotic-assisted total knee arthroplasty (rTKA) had greater knee-specific outcomes, improved fulfilment of expectations, health-related quality life (HRQoL), and patient satisfaction when compared with manual TKA (mTKA).
Background: Unicompartmental knee arthroplasty has been associated with consistently worse implant survival rates than total in worldwide registers. The rate of revision and the proportion revisions performed for unexplained pain after either a unicompartmental or were studied to assess if there is evidence support hypothesis that numbers differ between these two types. Methods: Using data from National Joint Registry (NJR) England Wales, we identified 402,714 primary arthroplasties (366,965...
The popularity of cementless total hip replacement (THR) has surpassed cemented THR in England and Wales. This retrospective cohort study records survival time to revision following primary with the most common combination (accounting for almost a third all THRs), explores risk factors independently associated failure, using data from National Joint Registry Patients osteoarthritis who had DePuy Corail/Pinnacle implanted between establishment registry 2003 31 December 2010 were included...
Modern metal-on-metal hip resurfacing has been widely performed in the United Kingdom for over a decade. However, literature reports conflicting views of benefits: excellent medium- to long-term results with some brands specific subgroups, but high failure rates and local soft-tissue reactions others. The National Joint Registry England Wales (NJR) collected data on all resurfacings since 2003. This retrospective cohort study recorded survival time revision from procedure, exploring risk...
Abstract There continues to be some dissatisfaction with the function of total knee arthroplasties (TKA). “Mid‐range instability” has been linked multi‐radius femoral components allowing transient ligament slackness and instability during flexion. Single‐radius designs have introduced avoid this. We compared kinematics stability eight natural knees versus single‐radius TKAs in vitro. The loading conditions imposed across range active extension were anterior–posterior drawer forces,...