A5015462889- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Spondyloarthritis Studies and Treatments
- Immunodeficiency and Autoimmune Disorders
- Inflammatory Myopathies and Dermatomyositis
- Lymphoma Diagnosis and Treatment
- Reproductive Health and Contraception
- Systemic Sclerosis and Related Diseases
- Chronic Lymphocytic Leukemia Research
- Healthcare Systems and Technology
- Higher Education Learning Practices
- Monoclonal and Polyclonal Antibodies Research
- Higher Education and Employability
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- HIV-related health complications and treatments
- Education Systems and Policy
- Autoimmune Bullous Skin Diseases
- Peripheral Neuropathies and Disorders
- Parvovirus B19 Infection Studies
- Primary Care and Health Outcomes
- Cutaneous lymphoproliferative disorders research
- Cystic Fibrosis Research Advances
- HIV Research and Treatment
University Hospital Lewisham
2011-2024
Guy's Hospital
2023
University of Manchester
2010-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2023
The University of Notre Dame Australia
2021
Lewisham and Greenwich NHS Trust
2020
King's College Hospital NHS Foundation Trust
2019
University of Nottingham
2018
The University of Western Australia
2016
King's College London
2005-2015
Objective. We determined the amount of fatigue experienced by patients with RA, and its relationship to synovitis, pain other common clinical features. also examined what extent RA is improved disease-modifying antirheumatic drugs (DMARDs) anti-tumour necrosis factor (TNF) therapy. Methods. studied two cohorts 238 274 cross-sectionally treatment responses in 30 starting anti-TNF 54 DMARDs followed for 3 6 months. measured using visual analogue scores (VAS) Medical Outcomes Study Short Form...
Objective. We evaluated fibromyalgic RA to determine its clinical impact, identification using core assessments and influence identifying active disease activity scores (DAS-28).
Older people admitted to hospital in an emergency often have prolonged inpatient stays that worsen their outcomes, increase health-care costs, and reduce bed availability. Growing evidence suggests the biopsychosocial complexity of problems, which include cognitive impairment, depression, anxiety, multiple medical illnesses, care needs resulting from functional dependency, prolongs by making treatment less efficient planning post-discharge more difficult. We aimed assess effects enhancing...
In order to develop interventions optimize MTX use for the treatment of RA we evaluated rate of, reasons and predictors non-adherence during first 6 months therapy.The Rheumatoid Arthritis Medication Study (RAMS) is a prospective multicentre cohort study incident users in UK. Prior commencement demographic, clinical psychological data were collected. A weekly patient-completed diary recorded dose, possible side effects adherence over 26 weeks. The number non-adherent weeks was calculated....
Objective. We evaluated the influence of demographic and clinical factors on pain thresholds in patients with rheumatoid arthritis (RA). Methods. A cross-sectional observational study (105 RA) assessed using an algometer. Regression analysis examined assessments. Results. Pain (median 289, interquartile range 89–434) correlated assessments disease activity (tender joint counts), disability (Health Assessment Questionnaire), fatigue, depression, anxiety. Ordinal logistic regression showed...
Abstract Background The aims of this study were to identify common patterns comorbidities observed in people living with HIV (PLWH), using a data-driven approach, and evaluate associations between identified. Methods A wide range assessed PLWH participating 2 independent cohorts (POPPY: UK/Ireland; AGEhIV: Netherlands). presence/absence each comorbidity was determined mix self-reported medical history, concomitant medications, health care resource use, laboratory parameters. Principal...
Abstract Objectives To estimate prevalence rates and identify baseline predictors of adverse events (AEs) over the first year treatment in patients with RA starting MTX. Methods Data came from UK Rheumatoid Arthritis Medication Study (RAMS), a prospective cohort This analysis included aged ≥18 years physician diagnosed symptom duration ≤2 years, who were commencing MTX for time. AEs recorded by interviewing at 6- 12-month follow-up visits. The period are reported 0–6 months, 6–12 months 0–12...
The impact of autoantibody profiles on prognosis idiopathic inflammatory myositis associated interstitial lung disease (IIM-ILD) and spectrum ILD with Myositis Specific Antibodies (MSA) remains unclear. This retrospective cohort study examines whether serological are mortality longitudinal function change.Baseline clinical/demographic characteristics follow-up consecutive adult patients IIM-ILD or Interstitial Pneumonia Autoimmune Features (IPAF) positive for MSAs were extracted from three...
A number of recent reports published in the UK have put quality care adults with Rheumatoid Arthritis (RA) centre stage. These documents set high standards for health professionals and commissioning bodies that need to be implemented into routine clinical practice. We therefore obtained views recipients providers inner city settings as what they perceive are barriers providing integrated care. conducted focus groups face interviews between 2005-8 79 participants (patients, carers, specialist...
Rheumatoid arthritis (RA) treatment paradigms have shifted over the last two decades. There has been increasing emphasis on combination disease modifying anti-rheumatic drug (DMARD) therapy, newer biologic therapies become available and there is a greater focus achieving remission. We evaluated impact of changes activity scores for 28 joints (DAS28) disability measured by health assessment questionnaire (HAQ). Four cross-sectional surveys between 1996 2014 in adjacent secondary care...
We assessed whether HIV status was associated with white matter hyperintensities (WMH), a neuroimaging correlate of cerebral small vessel disease (CSVD), in men aged ≥50 years. A cross-sectional substudy nested within larger cohort study. Virologically suppressed living (MLWH) and demographically matched HIV-negative underwent magnetic resonance imaging (MRI) at 3 Tesla. Sequences included volumetric three-dimensional (3D) T1-weighted, fluid-attenuated inversion recovery pseudocontinuous...
<b>Background:</b> Rheumatoid arthritis (RA) tends to remit during pregnancy, with more patients achieving remission in the third trimester, coinciding an increase levels of α-fetoprotein (AFP). In vitro and animal studies have shown that AFP has immunomodulatory properties. MM-093 is a non-glycosylated, recombinant version human AFP. <b>Objective:</b> To assess safety, tolerability clinical effects 12-week, randomised, double-blind, placebo-controlled study. <b>Methods:</b> 12 RA, who had...
Widening university access to students from low socio-economic status (LSES) and non-traditional backgrounds has been a key equity objective for Australian universities, particularly since the 2008 Review into Higher Education (Bradley, Noonan, Nugent & Scales, 2008). Aspire UWA is an pathway that aims inform aspirations build academic attainment through direct involvement with who are “most able least likely” benefits of higher education (Harris, 2010, p. 7). Through forming long-term...
To understand the relationships between deprivation and obesity with self-reported disability disease activity in people RA, to determine whether BMI mediates relationship area-level these outcomes.Data came from Rheumatoid Arthritis Medication Study (RAMS), a 1-year multicentre prospective observational cohort of RA recruited rheumatology centres across England commencing MTX for first time. A total 1529 1626 were included who had baseline at least one follow-up measurement 6 or 12 months...
Objectives To assess the impact of specialist contraceptive support after abortion on effective use at six months and subsequent abortions within two years. Methods Multicentre randomised controlled trial among women undergoing induced in three London boroughs. Allocation was through electronically concealed stratified randomisation by centre, blinding clinicians participants to arm allocation until interventions. Control group received standard care, comprising advice follow up with their...
Abstract Introduction Septic arthritis can lead to permanent joint destruction, with a mortality rate of 7-15% despite antibiotic treatment. However, it be challenging diagnose, as synovial fluid cultures are not always positive. In recent years, 16S Polymerase Chain Reaction (PCR) has been more accessible, which helpful when there is diagnostic uncertainty. We present case knee swelling in an elderly man known haemochromatosis. Although initial (SF) analysis showed crystals, his...