A5016759142- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Spondyloarthritis Studies and Treatments
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Hepatitis C virus research
- Monoclonal and Polyclonal Antibodies Research
- Systemic Sclerosis and Related Diseases
- Musculoskeletal Disorders and Rehabilitation
- Telemedicine and Telehealth Implementation
- Pregnancy and Medication Impact
- Biosimilars and Bioanalytical Methods
- Inflammatory mediators and NSAID effects
- Psoriasis: Treatment and Pathogenesis
- Hematopoietic Stem Cell Transplantation
- Pharmaceutical studies and practices
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Otitis Media and Relapsing Polychondritis
- Healthcare Systems and Public Health
- Asthma and respiratory diseases
- Eosinophilic Disorders and Syndromes
- Anesthesia and Pain Management
- Dermatological and Skeletal Disorders
- Peripheral Neuropathies and Disorders
Versus Arthritis
2012-2025
Keele University
2012-2025
Midlands Partnership NHS Foundation Trust
2018-2025
Phoenix (United States)
2024
Vitalant
2024
King's College London
2010-2022
Haywood Community Hospital
2017-2022
Guy's Hospital
2011-2018
Transnational Press London
2017
Hospital for Sick Children
2017
Abstract Introduction UK guidelines recommend that all early active rheumatoid arthritis (RA) patients are offered combination disease-modifying antirheumatic drugs (DMARDs) and short-term corticosteroids. Anti-citrullinated protein antibody (ACPA)-positive ACPA-negative RA may differ in their treatment responses. We used data from a randomized controlled trial - the Combination Anti-Rheumatic Drugs Early (CARDERA) to examine whether responses intensive treatments by ACPA status. Methods The...
The improved characterisation of risk factors for rheumatoid arthritis (RA) suggests they could be combined to identify individuals at increased disease risks in whom preventive strategies may evaluated. We aimed develop an RA prediction model capable generating clinically relevant predictive data and determine if it better predicted younger onset (YORA). Our novel modelling approach odds ratios 15 four-digit/10 two-digit HLA-DRB1 alleles, 31 single nucleotide polymorphisms (SNPs)...
Reduced mental health (MH) is prevalent in rheumatoid arthritis (RA). Although longitudinal studies are limited, there evidence that depression associated with worse disease outcomes. We evaluated reciprocal relationships between MH, RA severity, and genetic risks for 2 years a well-characterized cohort of patients.We 520 early patients previously enrolled to two clinical trials. MH was measured using the short form-36 domain component summary scores (MCS). MCS/MH associations over activity...
Abstract Objectives This study aims to explore patients' and clinicians' understanding experiences of refractory disease (RD) persistent physical emotional symptoms (PPES) in patients with inflammatory arthritis (IA), namely rheumatoid or polyarticular juvenile idiopathic from their perspectives through interviews and/or focus groups. Design A qualitative was conducted, following a pragmatic epistemology approach framework analysis employed. Methods Semi‐structured groups IA ( n = 25)...
Antibiotic-induced disturbances of the human microbiota have been implicated in development chronic autoimmune conditions. This study aimed to assess whether antibiotic use is associated with onset rheumatoid arthritis (RA). A nested case-control was conducted utilising data from primary care Clinical Practice Research Datalink (CPRD). Patients an incident diagnosis RA were identified (1995–2017). Each case matched on age, gender, and general practice ≥ 5 controls without RA. Conditional...
Abstract Background Gabapentinoids are increasingly prescribed in inflammatory arthritis (IA), despite no trial evidence for efficacy at managing pain this population. Observational studies non-IA populations suggest gabapentinoids associated with fractures but limited by methodological heterogeneity/potential residual confounding. Patients IA generally have an increased risk of fracture so may be particularly vulnerable. We examined the relationship between and patients who had all been a...
The emphasis on treating rheumatoid arthritis (RA) intensively reduces disease activity but its impact in routine care is uncertain. We evaluated temporal changes activities and outcomes a 10-year prospective observational cohort study of patients at one unit. Guy's St Thomas' RA was established 2005. It involved most managed this hospital. Clinical diagnoses were made by rheumatologists. Patients seen regularly care. Each visit included measurement scores for 28 joints (DAS28), health...