A5054567279- Autoimmune and Inflammatory Disorders Research
- Kawasaki Disease and Coronary Complications
- SARS-CoV-2 and COVID-19 Research
- Inflammasome and immune disorders
- Vasculitis and related conditions
- Renal Diseases and Glomerulopathies
- Spondyloarthritis Studies and Treatments
- Systemic Lupus Erythematosus Research
- Viral Infections and Immunology Research
- Adolescent and Pediatric Healthcare
- Immunodeficiency and Autoimmune Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- COVID-19 Clinical Research Studies
- Celiac Disease Research and Management
- T-cell and B-cell Immunology
- Orthopedic Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Streptococcal Infections and Treatments
- Platelet Disorders and Treatments
- Osteomyelitis and Bone Disorders Research
- Ear Surgery and Otitis Media
- Microscopic Colitis
- Atherosclerosis and Cardiovascular Diseases
- Influenza Virus Research Studies
- Otolaryngology and Infectious Diseases
Tel Aviv University
2019-2024
Tel Aviv Sourasky Medical Center
2019-2024
Schneider Children's Medical Center
2022
University of California, San Francisco
2018-2021
Shaare Zedek Medical Center
2013-2020
UCSF Benioff Children's Hospital
2018
Hadassah Medical Center
2013
Adolescents with juvenile-onset autoimmune inflammatory rheumatic diseases (AIIRDs) could be at risk for disease flare secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or withholding anti-inflammatory therapy. While vaccination can protect against 2019 (COVID-19), safety and immunogenicity data regarding anti-SARS-CoV-2 vaccines among adolescents AIIRDs are limited. This international, prospective, multicentre study evaluated the of BNT162b2 vaccine young...
To assess current treatment in macrophage activation syndrome (MAS) worldwide and to highlight any areas of major heterogeneity practice.
COVID-19-associated pediatric vasculitis, other than Kawasaki disease (KD)-like vasculitis in multisystem inflammatory syndrome children (MIS-C), is very rare. This study sought to analyze the characteristics, treatment, and outcomes patients with (excluding KD-like MIS-C).The inclusion criteria were as follows: 1) age <18 years at onset; 2) evidence of vasculitis; 3) SARS-CoV-2 exposure; 4) ≤3 months between exposure onset. Patients MIS-C excluded. The features subset our cohort who had IgA...
To explore the long-term safety and dynamics of immune response induced by second third doses BNT162b2 mRNA COVID-19 vaccine in adolescents with juvenile-onset autoimmune inflammatory rheumatic diseases (AIIRDs) compared healthy controls.This international prospective study included AIIRDs controls vaccinated two (AIIRDs n = 124; 80) or three 64; 30) vaccine, evaluated for side-effects, disease activity, breakthrough infection rates severity, anti-spike S1/S2 IgG antibody titers a sample...
Objective Magnetic resonance imaging (MRI) is pivotal in the assessment of early sacroiliitis children. We aimed to evaluate agreement between local radiology reports and central reviewers for active inflammation structural damage at sacroiliac (SI) joints. Methods Eight hospitals each contributed up 20 cases consecutively imaged children adolescents with juvenile idiopathic arthritis suspected sacroiliitis. Studies were independently reviewed by 3 experienced musculoskeletal pediatric...
Abstract Objectives The effectiveness of the BNT162b2 mRNA COVID-19 vaccine for adolescents with juvenile-onset inflammatory or immune rheumatic diseases (IRDs) is unknown. Several studies have suggested attenuated immunogenicity in patients IRD. This study evaluated preventing infection IRD compared controls without disease. Methods We used data from Clalit Health Services, largest health-care organization Israel, to conduct an observational cohort February December 2021, involving 12–18...
Abstract Background The SPARCC sacroiliac joint inflammation (SIS) and structural (SSS) scores are reliable measures to quantify abnormalities in the pediatric joint. We aimed evaluate utility of online calibration modules for SIS SSS reliability their component change scores. Methods Change score 6 raters was assessed by overall pairwise intraclass correlation coefficients (ICCs) before after use real-time iterative (RETIC) both comprised 20 adult cases. Acceptable ICC > 0.7 0.5 all...
While most countries provide safe and effective influenza vaccines for at-risk groups, vaccine coverage among children with rheumatic diseases remains uncertain. This study investigated vaccination rates in juvenile idiopathic arthritis (JIA) during the 2019-2020 season assessed knowledge attitudes of caregivers JIA regarding vaccination. The secondary aims were to identify barriers explore strategies improve rates. A multi-centre, cross-sectional anonymous survey was conducted 7 assess...
Abstract This paper aims to compare the cellular immune response SARS-CoV-2 BNT162b2 vaccine of pediatric patients with autoimmune inflammatory rheumatic disease (pAIIRD) and healthy controls. A prospective longitudinal study was conducted between April 2021 December 2022 at Tel Aviv Medical Center. Children &lt;18 years, pediatric-onset AIIRD controls, who have received least two doses vaccine, were included. Humoral evaluated by serum levels anti-SARS-CoV-2 receptor-binding domain...
To compare final height to mid-parental target among adults with childhood-onset systemic lupus erythematosus (cSLE) versus adult-onset SLE (aSLE), and evaluate the impact of age at onset on height. Data derived from Lupus Outcomes Study, a longitudinal cohort SLE, was used for this cross-sectional analysis (N = 728). Participants aged 18–63 years complete data were included 566) classified as cSLE if diagnosis < 18 72). The Tanner formula calculate Multivariate linear regression determine...
Previous studies have suggested that hepatitis B virus (HBV) vaccines may be less immunogenic in individuals with celiac disease (CD). A pre-S vaccine (Sci-B-Vac) has demonstrated superior immunogenicity compared standard HBV several diseases. We the short-term of a (Engerix B) for repeat vaccination seronegative, previously immunized patients CD.Participants were 1 to 18-year-old children CD who despite infancy had nonprotective surface antibody (HBs-Ab) concentrations (≤10 mIU/mL)....
Background Following the Coronavirus Disease-19 (COVID-19) pandemic outbreaks, hyperinflammatory condition termed Multisystem Inflammatory Syndrome in Children (MIS-C) became a healthcare issue worldwide. Since December 2020 mRNA vaccine against SARS-CoV-2 has become available with good safety profile. However, evidence regarding and vaccination strategies children previous MIS-C is still lacking. The aim of our study was to investigate current approach international centers anti-SARS-CoV-2...
Since the development of COVID-19 vaccines, more than 4.8 billion people have been immunized worldwide. Soon after vaccinations were initiated, reports on cases myocarditis following second vaccine dose emerged. This study aimed to report our experience with adolescent and young adults who developed post-COVID-19 compare these patients a cohort acquired pediatric inflammatory multisystem syndrome (PIMS/PIMS-TS) infection.We collected reported vaccination (Pfizer mRNA BNT162b2) from all...
Abstract Background Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children, causing significant morbidity. Despite dramatic improvement treatment, many patients do not achieve complete remission, and biomarkers for subclinical disease, flares, response to treatment are lacking. Neutrophils neutrophil extracellular traps (NETs) play key roles pathogenesis of autoimmune inflammatory conditions. In this study, we characterized enzyme activity NETs formation...
To evaluate the effect of gluten-free diet (GFD) on hepatitis B surface antibody (HBsAb) concentrations among previously immunized pediatric celiac disease (CD) subjects.We retrospectively evaluated CD subjects in serological remission who were for virus as infants. The temporal relationship between HBsAb concentration, amount time a GFD, and age evaluated.Overall, 373 analyzed: 156 with sampled prior to GFD initiation 217 after remission. Median at concentration measurement those before was...
Abstract Objective Granulomatosis with polyangiitis (GPA) is an ANCA-associated vasculitis. The 2022 ACR/EULAR-endorsed classification criteria for GPA was derived using data only from adult patients. We aimed to assess the performance of ACR/EULAR in paediatric patients and compare it EULAR/Pediatric Rheumatology International Trials Organization (PRINTO)/Pediatric European Society (PReS)-endorsed Ankara 2008 GPA. Methods Retrospective 20 centres 9 countries were evaluated. diagnosis made...
To identify predictors of a severe clinical course multisystem inflammatory syndrome in children (MIS-C), as defined by the need for inotropic support.This retrospective study included patients diagnosed with MIS-C (according to CDC definition) nine Israeli and one US medical centre between July 2020 March 2021. Univariate multivariate regression models assessed odds ratio (OR) demographic, clinical, laboratory imaging variables during admission hospitalization disease.Of 100 patients, 61...