A5029693826- Kawasaki Disease and Coronary Complications
- Autoimmune and Inflammatory Disorders Research
- SARS-CoV-2 and COVID-19 Research
- Inflammasome and immune disorders
- Streptococcal Infections and Treatments
- Pediatric Pain Management Techniques
- Infant Development and Preterm Care
- Immunodeficiency and Autoimmune Disorders
- Viral Infections and Immunology Research
- Vasculitis and related conditions
- Travel-related health issues
- Global Maternal and Child Health
- Otolaryngology and Infectious Diseases
- Cardiovascular Issues in Pregnancy
- Dermatological and COVID-19 studies
- Family and Patient Care in Intensive Care Units
- interferon and immune responses
- Systemic Lupus Erythematosus Research
- Child and Adolescent Health
- Immune responses and vaccinations
- Peripheral Neuropathies and Disorders
- Infant Health and Development
- Bacterial Infections and Vaccines
- Virology and Viral Diseases
- Otitis Media and Relapsing Polychondritis
Carmel Medical Center
2015-2025
Wilhelmina Children's Hospital
2023-2025
University Medical Center Utrecht
2023-2025
Technion – Israel Institute of Technology
2022-2025
Clalit Health Services
2022-2025
Haifa Medical Center
2022
Schneider Children's Medical Center
2022
The COVID-19 pandemic has raised concerns about potential links between SARS-CoV-2 infection and autoimmune diseases. This study investigated changes in the incidence rate (IR) of diseases among children following pandemic's onset. A retrospective cross-sectional analyzed data from Clalit Health Services, Israel's largest healthcare provider, examining IR different aged 0-18. compared pre-pandemic (2019) with pandemic/post-pandemic periods (2020-2023), encompassing a cohort over 1.5 million...
Our aims were to clinically and epidemiologically characterize rheumatic fever (RF) in the current era Israel. Although there has been a steady decline incidence of RF western world, evidence disease resurgence developed countries continues be published. The paucity recent epidemiological data prompted our study.Medical files retrospectively reviewed for all children with tertiary pediatric university-affiliated hospital from 1993 2017. Main outcome measures patients related characteristics,...
To evaluate immunogenicity, effectiveness and safety of COVID-19 vaccination in patients with pediatric autoimmune inflammatory rheumatic disease (pedAIIRD). A prospective cohort study was performed at the rheumatology department Wilhelmina Children’s Hospital Utrecht, Netherlands. Vaccination dates, cases vaccine-related adverse events (AEs) were registered for all pedAIIRD during regular clinic visits from March 2021 – August 2022. SARS-CoV-2 IgG antibody levels T-cell responses measured...
Since the development of COVID-19 vaccines, more than 4.8 billion people have been immunized worldwide. Soon after vaccinations were initiated, reports on cases myocarditis following second vaccine dose emerged. This study aimed to report our experience with adolescent and young adults who developed post-COVID-19 compare these patients a cohort acquired pediatric inflammatory multisystem syndrome (PIMS/PIMS-TS) infection.We collected reported vaccination (Pfizer mRNA BNT162b2) from all...
To study short and long-term disease activity vaccine-related adverse events in a cohort of JIA patients who received the live attenuated measles-mumps-rubella (MMR) booster vaccine while being treated with immunosuppressive immunomodulatory therapies. A retrospective was performed UMC Utrecht, clinical therapeutic data were collected from electronic medical records for two visits before after MMR patients. Drug therapy related to requested during or by phone interviews. Associations between...
Two cases of Kawasaki disease (KD) presented as persistent lung consolidation associated with
To identify predictors of a severe clinical course multisystem inflammatory syndrome in children (MIS-C), as defined by the need for inotropic support.This retrospective study included patients diagnosed with MIS-C (according to CDC definition) nine Israeli and one US medical centre between July 2020 March 2021. Univariate multivariate regression models assessed odds ratio (OR) demographic, clinical, laboratory imaging variables during admission hospitalization disease.Of 100 patients, 61...
<title>Abstract</title> Aim: Evaluate clinical characteristics and disease severity in specific ethnic groups of FMF patients homozygous for the E148Q mutation, examine contribution a single allele V726A mutation to severity. Methods: A retrospective cohort study included mutation. The Characteristics with E148Q/E148Q + V726A/- MEFV mutations were compared. primary outcome measure was as measured by Tel Hashomer Key Severity Score among alone or an additional Results: total 61 which 24 (39%)...
Abstract Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disease, linked to mutations in the MEFV gene. The p.E148Q variant, found on exon 2, has uncertain role FMF, with debates whether it a benign polymorphism or pathogenic mutation. This study aimed assess clinical characteristics and severity of FMF patients homozygous for variant evaluate impact p.V726A these patients. retrospective cohort analyzed data from electronic medical records at Carmel Medical...
Abstract This article underscores the critical importance of thorough physical examinations and need to investigate secondary causes in cases refractory pneumothorax. The identification hereditary multiple exostoses (HME) as underlying condition highlights necessity considering rare etiologies, particularly atypical presentations. While typically affect long bones, they can also involve ribs scapulae, leading complications such In pediatric patients, where symptoms may arise from a single...
Vaccines, especially live attenuated vaccines, in children with JIA pose a great challenge due to both potential lower immunogenicity and safety as result of immunosuppressive treatment. For many years, the Netherlands, patients receive measles-mumps-rubella (MMR) booster vaccine at age nine years part national immunization program.To study long-term humoral immunoprotection large cohort who received MMR while being treated immunomodulatory therapies Wilhelmina Children's Hospital Utrecht,...
Background: It remains unknown whether children and young people with rheumatic musculoskeletal diseases (RMD) who acquire COVID-19 infection have a more severe course, due to either underlying disease or immunosuppressive treatments. Objectives: To describe outcomes among RMD infection. Methods: All <18 years of age (presumptive confirmed) reported the EULAR Database, which collects details regarding diagnosis treatment, COVID outcomes, between 27 March 2020 29 January 2021 (cutoff date...
Objective Characterization of the stages that patients with juvenile idiopathic arthritis (JIA) pass until they are diagnosed, and analysis different causes lead to a delay in JIA diagnosis Israel. Methods This is retrospective cohort study conducted 8 pediatric rheumatology centers All diagnosed between October 2017 2019 were included study. Demographic, clinical, data regarding referring physicians collected from hospital community medical charts. Results Of 207 study, 201 cases analyzed,...
Objectives: To study short and long-term disease activity vaccine-related adverse events in a cohort of JIA patients who received the live-attenuated measles, mumps rubella (MMR) booster vaccine while being treated with immunosuppressive immunomodulatory therapies.Methods: A retrospective was performed UMC Utrecht, clinical therapeutic data were collected from electronic medical records for two visits prior five after MMR patients. Drug therapy related to requested during or by phone...
Background Since the development of COVID 19 vaccines, more than 300 million people have been immunized worldwide. Soon after vaccinations were initiated, reports on cases myocarditis following second vaccine dose emerged. Objectives This study aims to report our experience with nine patients post COVID-19 myocarditis, and compare them a cohort who presented paediatric inflammatory multisystem syndrome (PIMS / PIMS-TS) infection. Methods We collected all reported developed vaccination...
Periorbital edema as a sole initial manifestation, without any evidence of other significant cutaneous or systemic involvement, is rare in lupus erythematosus (SLE). We report 16 year-old female who presented with bilateral periorbital the manifestation SLE. As disease progressed, kidney biopsy was performed demonstrating nephritis stage II. This emphasizes importance index suspicion SLE one differential diagnosis patients relevant clinical context.