A5029064770- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Kawasaki Disease and Coronary Complications
- Adolescent and Pediatric Healthcare
- Vasculitis and related conditions
- Renal Diseases and Glomerulopathies
- SARS-CoV-2 and COVID-19 Research
- Immunodeficiency and Autoimmune Disorders
- Acute Lymphoblastic Leukemia research
- Atherosclerosis and Cardiovascular Diseases
- Spondyloarthritis Studies and Treatments
- Immune Cell Function and Interaction
- Ocular Diseases and Behçet’s Syndrome
- Viral Infections and Vectors
- Rheumatoid Arthritis Research and Therapies
- Gout, Hyperuricemia, Uric Acid
- Childhood Cancer Survivors' Quality of Life
- Streptococcal Infections and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Peptidase Inhibition and Analysis
- Systemic Lupus Erythematosus Research
- Otitis Media and Relapsing Polychondritis
- Complement system in diseases
- Cardiovascular Issues in Pregnancy
- COVID-19 Impact on Reproduction
Rambam Health Care Campus
2014-2025
Technion – Israel Institute of Technology
2015-2024
University of Ljubljana
2023
Weatherford College
2023
Justus-Liebig-Universität Gießen
2021-2023
Meyer Children's Hospital
2011-2022
Istituto Giannina Gaslini
2020
Rappaport Family Institute for Research in the Medical Sciences
2020
University of Toronto
2008-2013
SickKids Foundation
2011-2013
To determine and compare the prevalence of disturbed sleep in JIA JDM relationship disturbance to pain, function, disease activity medications.One hundred fifty-five patients (115 JIA, 40 JDM) were randomly sampled mailed questionnaires. Sleep was assessed by self-report (SSR) children's habits questionnaire (CSHQ). Fatigue, pain function paediatric quality life inventory (PedsQL) visual analogue scales (VASs). Joint counts self-reported.Eighty-one per cent responded, whom 44% reported (CSHQ...
Following the introduction of ILAR criteria for juvenile idiopathic arthritis, psoriatic arthritis (JPsA) has become a better recognized category within inflammatory arthritides childhood. There are fewer reports describing characteristics and long-term outcome patients with JPsA than other subtypes JIA.The aim our study was to determine clinical course define subgroups JPsA.Clinical records all meeting were reviewed divided into 4 groups depending on their features onset type. Patient at...
Pediatric inflammatory multisystem syndromes associated with Severe Acute Respiratory Syndrome Coronavirus 2 are emerging in recent reports. We describe a patient critical illness consistent atypical Kawasaki disease cardiac dysfunction and abdominal involvement presenting weeks after infection. Our showed unique central nervous system small vessel vasculitis profound hypocomplementemia, both not previously reported case descriptions may hint at possible mechanisms.
Purpose CLCN2 is a gene that encodes the voltage-gated chloride channel protein 2 in human brain and eyes. While mutations this have been associated with leukoencephalopathy as well ocular manifestations including optic neuropathy choroidopathy, here we report for first time case of severe proliferative retinopathy patient mutation. Observations A 12-year-old girl Familial Mediterranean Fever (FMF) was referred due to blurred vision both Ophthalmoscopic examination revealed mild vitreous...
Prolidase deficiency (PD) is a rare autosomal recessive disorder which may have wide spectrum of clinical features. These features include characteristic facies, cognitive impairment, rashes or skin ulceration, splenomegaly, recurrent infections involving mainly the respiratory system, and iminodipeptiduria. The caused by mutation in PEPD gene.To describe cohort unrelated PD patients from Northern Israel whose inborn error metabolism was associated with systemic lupus erythematosus (SLE) to...
To assess efficacy, pharmacokinetics (PK) and safety of intravenous (i.v.) golimumab in patients with polyarticular-course JIA (pc-JIA).Children aged 2 to <18 years active pc-JIA despite MTX therapy for ≥2 months received 80 mg/m2 at weeks 0, 4, then every 8 through week 52 plus weekly 28. The primary major secondary endpoints were PK exposure model-predicted steady-state area under the curve (AUCss) over an 8-week dosing interval 28 52, respectively. ACR response also assessed.In total, 127...
To explore the long-term safety and dynamics of immune response induced by second third doses BNT162b2 mRNA COVID-19 vaccine in adolescents with juvenile-onset autoimmune inflammatory rheumatic diseases (AIIRDs) compared healthy controls.This international prospective study included AIIRDs controls vaccinated two (AIIRDs n = 124; 80) or three 64; 30) vaccine, evaluated for side-effects, disease activity, breakthrough infection rates severity, anti-spike S1/S2 IgG antibody titers a sample...
Juvenile psoriatic arthritis (JPsA), a subtype of juvenile idiopathic (JIA), constitutes 5% JIA. The literature is inconsistent regarding features JPsA, and physicians debate whether it distinct entity within A biphasic age onset distribution has been noted. Early-onset disease characterized by female predominance, small joint involvement, dactylitis, positive antinuclear antibodies. Late-onset JPsA resembles adult-onset (PsA), with male psoriasis, enthesitis, axial disease. Recent studies...
Objective We examine levels of candidate blood‐based biomarkers (CBBs) in patients with juvenile idiopathic arthritis (JIA) treated tofacitinib. Methods Patients JIA who participated clinical trial NCT02592434 received tofacitinib from baseline to week 18. Serial serum samples were assayed for CBBs (S100A8/9, S100A12, interleukin‐18 [IL‐18], amyloid A, resistin, vascular endothelial growth factor, angiopoietin‐1, angiopoietin‐2, matrix metalloproteinase 8 [MMP8], MMP2, tissue inhibitor...
Background: Tofacitinib is an oral JAK inhibitor that being investigated for JIA. Objectives: To assess tofacitinib efficacy and safety in JIA patients (pts). Methods: This was a Phase 3, randomised, double-blind (DB), placebo (PBO)-controlled withdrawal study pts aged 2−<18 years with polyarticular course (pcJIA), PsA or ERA ( NCT02592434 ). In the 18-week open-label Part 1, received weight-based doses (5 mg BID lower). Pts ≥JIA ACR30 response at Week (W)18 were randomised 1:1 DB 2...
Abstract Background Protracted febrile myalgia syndrome (PFMS) is a rare complication of Familial Mediterranean fever (FMF). The diagnosis based on clinical symptoms and often challenging, especially when PFMS the initial manifestation FMF. aim this report was to describe magnetic resonance imaging (MRI) findings in pediatric patients with PFMS. Results There were three girls two boys ranging age from 6 months 16 years, all ancestry. Three had high-grade fever, elevated inflammatory markers....
Background/Purpose: Familial Mediterranean fever (FMF) is the most common hereditary autoinflammatory syndrome. FMF caused by mutations in MEFV gene which encodes pyrin protein, that has an important role activation of IL-1β. Evidence from case reports/series and one controlled study supports IL-1 blockage as a potential treatment for FMF. Canakinumab (CAN) selective fully human monoclonal anti-IL-1β antibody. This served proof concept to evaluate CAN pediatric colchicine resistant...
Since the development of COVID-19 vaccines, more than 4.8 billion people have been immunized worldwide. Soon after vaccinations were initiated, reports on cases myocarditis following second vaccine dose emerged. This study aimed to report our experience with adolescent and young adults who developed post-COVID-19 compare these patients a cohort acquired pediatric inflammatory multisystem syndrome (PIMS/PIMS-TS) infection.We collected reported vaccination (Pfizer mRNA BNT162b2) from all...
Although Henoch-Schonlein purpura (HSP) is the most common form of systemic vasculitis in children, long term effect HSP on endothelial function still not clear. The aim our study was to evaluate children and adolescents. This research an observational prospective study. group comprised 19 diagnosed with HSP. minimum interval between diagnosis testing 5 months. Endothelial evaluation assessed by a noninvasive technology named peripheral arterial tonometry, using EndoPAT™ device. method...
Abstract Objective It is common knowledge among clinicians who treat PFAPA (Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis) patients that emotional stress can trigger attacks similarly to other autoinflammatory diseases. However, it has never been proved scientifically. Our aim was examine whether serves as a for attacks. Methods Patients aged 3-12 years, with active PFAPA, from two Israeli medical centers were enrolled this study. Patient's parents reached via phone calls in...
Abstract Objectives Takayasu arteritis (TAK) is a large-vessel vasculitis rarely reported in children and infants. Most articles on paediatric TAK have not focused We present the largest case series of infantile TAK, aiming to identify its demographic clinical characteristics compare them with existing data older children. Methods conducted an international multicentre retrospective cohort study. Epidemiological were collected from patients’ charts six rheumatology centres. All patients met...