A5073502180- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Renal Diseases and Glomerulopathies
- IL-33, ST2, and ILC Pathways
- Complement system in diseases
- Vasculitis and related conditions
- Cancer-related molecular mechanisms research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Insect and Pesticide Research
- Venomous Animal Envenomation and Studies
- interferon and immune responses
- Cancer-related gene regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Reproductive System and Pregnancy
- Antimicrobial Resistance in Staphylococcus
- NF-κB Signaling Pathways
- Bacillus and Francisella bacterial research
- Bee Products Chemical Analysis
- Viral Infections and Vectors
- Polyomavirus and related diseases
- Virology and Viral Diseases
- Sarcoidosis and Beryllium Toxicity Research
- S100 Proteins and Annexins
Washington University in St. Louis
2013-2024
Baylor College of Medicine
2006
Rice University
2006
NK cell activation is controlled by the integration of signals from cytokine receptors and germline-encoded inhibitory receptors. cells undergo two distinct phases during murine CMV (MCMV) infection: a nonselective phase mediated proinflammatory cytokines specific driven signaling through Ly49H, an receptor that recognizes infected cells. We sought to delineate surface markers could distinguish had been activated nonselectively those specifically demonstrated stem Ag 1 (Sca-1) highly...
NK cells are innate lymphocytes important for host defense against viral infections and malignancy. However, the molecular programs orchestrating cell activation incompletely understood. MicroRNA-155 (miR-155) is markedly upregulated following cytokine of human mouse cells. Surprisingly, mature transduced to overexpress miR-155, from mice with cell-specific miR-155 overexpression, miR-155(-/-) all secreted more IFN-γ compared controls. Investigating further, we found that activated...
Abstract Natural killer (NK) cells are innate lymphoid that protect a host from viral infections and malignancies. MicroRNA‐146a (miR‐146a) is an important regulator of immune function highly expressed in NK further upregulated during murine cytomegalovirus (MCMV) infection. Here we utilized mice with global targeted deletion miR‐146a to understand its impact on the responses MCMV MiR‐146a −/− were protected lethal infection, which was intrinsic hematopoietic compartment based bone marrow...
Abstract Objectives Takayasu arteritis (TAK) is a large-vessel vasculitis rarely reported in children and infants. Most articles on paediatric TAK have not focused We present the largest case series of infantile TAK, aiming to identify its demographic clinical characteristics compare them with existing data older children. Methods conducted an international multicentre retrospective cohort study. Epidemiological were collected from patients’ charts six rheumatology centres. All patients met...
NK cell activation is controlled by the integration of signals from cytokine receptors and germline encoded inhibitory receptors. cells undergo two distinct phases during MCMV infection: a nonselective phase mediated pro-inflammatory cytokines specific driven signaling through Ly49H, an receptor that recognizes infected cells. We sought to delineate surface markers could distinguish had been activated nonselectively those specifically demonstrated Sca-1 highly upregulated viral infections...
Background Takayasu arteritis (TA) is a large vessel vasculitis rarely reported in children, and its incidence extremely low infants. Most articles on pediatric TA have not focused We present the largest case series of infantile aiming to characterize demographic clinical data compare it with existing older children. Objectives Characterize reagrding children Methods conducted an international multi-center retrospective cohort study. Epidemiological were collected from patient charts by...