A5024264842- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Advanced Breast Cancer Therapies
- Digestive system and related health
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Acute Myeloid Leukemia Research
- CRISPR and Genetic Engineering
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Retinoids in leukemia and cellular processes
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Vascular Malformations Diagnosis and Treatment
- TGF-β signaling in diseases
- Genomics and Chromatin Dynamics
- Virus-based gene therapy research
- Pluripotent Stem Cells Research
- Protein Kinase Regulation and GTPase Signaling
- Immune Cell Function and Interaction
- Protein Degradation and Inhibitors
- Mesenchymal stem cell research
Kyoto University Hospital
2020-2024
Kyoto University
2008-2021
Matsuyama Red Cross Hospital
2019-2020
Keio University
2016-2019
Bayer (Japan)
2018
Washington University in St. Louis
2008-2016
Japan Organization of Occupational Health and Safety
2016
Chugoku Rosai Hospital
2016
RIKEN BioResource Research Center
2004-2015
IBM Research - Tokyo
2015
OBJECTIVE—Berberine (BBR) activates AMP-activated protein kinase (AMPK) and improves insulin sensitivity in rodent models of resistance. We investigated the mechanism activation AMPK by BBR explored whether derivatization could improve its vivo efficacy. RESEARCH DESIGN AND METHODS—AMPK phosphorylation was examined L6 myotubes LKB1−/− cells, with or without Ca2+/calmodulin-dependent (CAMKK) inhibitor STO-609. Oxygen consumption measured isolated muscle mitochondria. The effect a derivative,...
<h3>Objective</h3> The technology for the growth of human intestinal epithelial cells is rapidly progressing. An exciting possibility that this system could serve as a platform individualised medicine and research. However, to achieve goal, culture must be enhanced so biopsies from individuals can used reproducibly generate cell lines in short time frame multiple, functional assays performed (ie, barrier function host–microbial interactions). <h3>Design</h3> We created large panel...
Gut, Heal Thyself Foods, drugs, and pathogens all represent possible threats to our guts on a daily basis. Fortunately, the gut is quite good at repairing itself—but how? Working in mice, Miyoshi et al. (p. 108 , published online 6 September; see Perspective by Barrett ) selectively injured intestinal crypts containing stem cells observed therepair process. The noncanonical Wnt ligand, Wnt5a, was required for crypt regeneration. Wnt5a inhibited cell proliferation, which paradoxically...
We previously Isolated the AML1 gene, which Is rearranged by t(8;21) translocation in acute myeloid leukemia. The gene is highly homologous to Drosophlla segmentation runt and mouse transcription factor PEBP2 a subunit gene. This region of homology, called Runt domain, responsible for DNA-binding protein-protein interaction. In this study, we isolated characterized various forms cDNAs reflect complex pattern mRNA species. Analysis these has led Identification two distinct proteins,...
The colonic epithelial lining undergoes constant replacement, driven by stem cells in crypts of Lieberkühn. Stem lost because damage or disease can be replaced adjacent that undergo fission. close proximity an extraordinary number luminal microbes creates a challenge for this repair process; infection must prevented while immune system activation and cell genetic minimized. To understand the factors modulate crypt/stem replacement mouse colon, we developed vivo acute injury analogous to...
G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) is a novel for acid. Tissue distribution and cell-type specificity of Gpbar1 mRNA suggest potential role the in endocrine system; however, precise physiological still remains to be elucidated. To investigate vivo, gene was disrupted mice. In homozygous mice, total pool size significantly decreased by 21-25% compared with that wild-type suggesting contributes homeostasis. order assess impact deficiency homeostasis more precisely, mice were...
Induced pluripotent stem (iPS) cells can be established from somatic cells. However, there is currently no strategy to generate corneal epithelial iPS In this study, we investigated whether could differentiated We tested 2 distinct sources: human adult dermal fibroblast (HDF)-derived (253G1) and limbal (HLEC)-derived (L1B41). first HLEC by introducing the Yamanaka 4 factors. Corneal were successfully induced stromal cell-derived inducing activity (SDIA) differentiation method, as Pax6+/K12+...