A5007860034- Inflammasome and immune disorders
- Kawasaki Disease and Coronary Complications
- interferon and immune responses
- Immunodeficiency and Autoimmune Disorders
- COVID-19 Clinical Research Studies
- Autoimmune and Inflammatory Disorders Research
- Immune Response and Inflammation
- Hematological disorders and diagnostics
- Systemic Sclerosis and Related Diseases
- Immune Cell Function and Interaction
- Gout, Hyperuricemia, Uric Acid
- Viral Infections and Immunology Research
- Systemic Lupus Erythematosus Research
- Long-Term Effects of COVID-19
- Pneumothorax, Barotrauma, Emphysema
- T-cell and B-cell Immunology
- demographic modeling and climate adaptation
- Effects of Environmental Stressors on Livestock
- Spondyloarthritis Studies and Treatments
- Ultrasound in Clinical Applications
- Vasculitis and related conditions
- Platelet Disorders and Treatments
- Thermal Regulation in Medicine
- Myasthenia Gravis and Thymoma
- Trace Elements in Health
Istituto Giannina Gaslini
2019-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2024
University of Genoa
2020-2022
Hôpital Necker-Enfants Malades
2020
BackgroundIL-1 plays a pivotal role in the inflammatory response during cytokine storm syndromes.ObjectiveOur aim was to analyze efficacy and safety of early anti-inflammatory treatment (AIT) with intravenous anakinra or without glucocorticoids coronavirus disease 2019 (COVID-19) pneumonia.MethodsWe performed retrospective single-center cohort study patients admitted for COVID-19 pneumonia from February 26 April 29, 2020, assess AIT (100 mg every 8 hours 3 days, tapering) alone combination...
Abstract Background Recurrent pericarditis (RP) is a complication (15–30%) of acute with an unknown etiology. Treatment regimen consists combination non-steroidal anti-inflammatory drugs (NSAIDs) and colchicine, the addition corticosteroids in resistant or intolerant cases. In last decade anakinra was shown as effective treatment patients colchicine steroid-dependent RP, initially anecdotal reports children more recently randomized trial. Canakinumab monoclonal antibody selectively blocking...
Multisystem inflammatory syndrome in children (MIS-C) is a potentially life-threatening disease temporally linked to SARS-CoV-2 whose incidence and clinical presentation may have been altered by the different variants vaccination.
Abstract Objectives To test the usefulness of an extended panel lymphocyte subsets in combination with Oliveira’s diagnostic criteria for identification autoimmune lymphoproliferative syndrome (ALPS) children referred to a paediatric rheumatology centre. Methods Patients from 2015 2018 our unit or autoinflammatory condition were retrospectively analysed. required [chronic lymphoproliferation and elevated double-negative T (DNT)] applied as first screening. Flow cytometry study included...
<h3>Background:</h3> In 2021 we described the baseline clinical information about 887 FMF patients enrolled in Eurofever registry since 2009. <h3>Objectives:</h3> We describe now first longitudinal data these patients. <h3>Methods:</h3> Patients with at least one follow-up visit were included a study. Demographic and analyzed. Disease activity maximum dose of colchicine defined according to 2016 EULAR recommendation [1]. <h3>Results:</h3> 1104 are November 2023, 574 males 530 females. The...
Background and Clinical Significance: The use of point-of-care ultrasound (POCUS) in emergency departments is rapidly growing due to its ability provide immediate accurate diagnostic information at the bedside. Furthermore, it can precise rapid on location multidistrict effusions patients with suspected lymphatic decompensation. Case Presentation: This unique clinical case report describes a patient who presented massive, chylous effusion secondary acute insufficiency, rare challenging...
Background: Colchicine is the standard treatment for Familiar Mediterranean Fever (FMF), however about 5% of patients experience colchicine resistance. There no definition Recently a panel experts elaborated new based on Delphi consensus approach. Objectives: We aim to describe main features disease and clinical outcome cohort FMF with particular interest resistance tolerability according definitions proposed by recent consensus. Methods: Since November 2009, 425 Italian pediatric adult...
<h3>Background</h3> Vaccine-preventable diseases are again emerging in our population after anti-vaccine campaign has started. In autoinflammatory (AID), vaccine triggered-disease is a well known phenomenon for Hyper-IgD/Mevalonate-Kinase Deficiency (MKD). CAPS, severe flares have been experienced pneumococcus vaccine, while PFAPA patients did not achieve sufficient and protective levels of antibodies. This evidence raised doubts physicians families about the safety vaccines....
Background: ALPS is a rare disorder due to defective apoptotic mechanism leading abnormal lymphoproliferation and autoimmunity. The disease difficult identify in the early phase when it may be misdiagnosed. Elevated TCR alpha-beta CD4-CD8- lymphocytes (double negative T DNT) together with hyperIgG, high levels of IL10, Il18, vitamin B12 soluble Fas ligand have been suggested as main hallmarks (1). Therefore, specific flow cytometry panel (DNT cells, ratio CD25+CD3+ HLA−DR+CD3+ increased...