A5058093236- Inflammasome and immune disorders
- Ultrasound in Clinical Applications
- Pericarditis and Cardiac Tamponade
- Hepatitis C virus research
- Systemic Lupus Erythematosus Research
- HIV/AIDS drug development and treatment
- Myasthenia Gravis and Thymoma
- Viral Infections and Immunology Research
- Vasculitis and related conditions
- Emergency and Acute Care Studies
- Trauma and Emergency Care Studies
- Pleural and Pulmonary Diseases
- Injury Epidemiology and Prevention
- Monoclonal and Polyclonal Antibodies Research
- HIV Research and Treatment
- Carcinogens and Genotoxicity Assessment
- Restraint-Related Deaths
- Hepatitis B Virus Studies
- Traffic and Road Safety
- Adrenal Hormones and Disorders
- DNA Repair Mechanisms
- Vestibular and auditory disorders
- Cardiac tumors and thrombi
- Cytomegalovirus and herpesvirus research
- Central Venous Catheters and Hemodialysis
Istituto Giannina Gaslini
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2024
University of Genoa
2021
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2006
University of Milan
2005
University of Chieti-Pescara
2004
Anti-CD20 antibodies are increasingly being used to treat idiopathic nephrotic syndrome (INS) in children. While they may allow steroid and calcineurin inhibitor withdrawal, repeated infusions of anti-CD20 often required maintain remission. Data on their potential toxicity INS needed, consider infusions.
Abstract Background Recurrent pericarditis (RP) is a complication (15–30%) of acute with an unknown etiology. Treatment regimen consists combination non-steroidal anti-inflammatory drugs (NSAIDs) and colchicine, the addition corticosteroids in resistant or intolerant cases. In last decade anakinra was shown as effective treatment patients colchicine steroid-dependent RP, initially anecdotal reports children more recently randomized trial. Canakinumab monoclonal antibody selectively blocking...
Abstract Pediatric drowning incidents, both fatal and non-fatal, represent a significant challenge in emergency medicine, particularly for children under 14 years of age. Drowning is leading cause unintentional injury-related deaths, with aged one to four being especially vulnerable. Accurate timely assessment, through chest imaging, such as radiography (CXR) lung point-of-care ultrasound (LUS), crucial evaluating pulmonary complications guiding treatment decisions. This retrospective study...
Abstract Backgrounds Dehydration is among the most common causes of Pediatric Emergency Department admission; however, no clinical signs, symptoms, or biomarkers have demonstrated sufficient sensitivity, specificity, reliability to predict dehydration. Methods We conducted a prospective, monocentric, observational study at Giannina Gaslini Hospital, tertiary care pediatric hospital. Our aimed compare inferior vena cava ultrasound measurement with volume depletion understand if point-of-care...
Vein line positioning represents one of the first diagnostic and therapeutic steps in Pediatric Emergency Department (PED); however, outcome this maneuver is frequently not as expected, especially for difficult-to-access (DIVA) patients. The standard technique (visual-palpatory) has a low success rate; hence ultrasound (US) assistance been suggested DIVA patients, although controversial results have obtained. Our study compared rate an intravascular (IV) access procedure at attempt, with...
The prognostic role of GB virus type C (GBV-C) viraemia in HIV-infected subjects treated with highly active antiretroviral therapy (HAART) is still undefined, aim this analysis to assess the relationship between GBV-C infection and response among initiating HAART when antiretroviral-naive. A prospective, observational study 400 patients measurements RNA, hepatitis (HCV) antibodies HCV RNA determined from plasma stored prior initiation, Time virological (achieving HIV ≤500 copies/ml)...
We examined the impact of a lamivudine-containing highly active antiretroviral therapy (HAART) regimen on 164 hepatitis B virus/HIV co-infected individuals starting their first HAART. Lamivudine-treated patients (accounting for 73% study population) showed significantly lower level alanine aminotransferase over follow-up [–81.1 mU/ml mean difference; 95% confidence intervals (95% CI): –30.3; –131.7, P=0.003] and reduced risk liver-related morbidity/mortality [Relative hazard (RH)=0.07; CI:...
Gardner-Diamond syndrome (GDS) is an uncommon clinical entity firstly described in 1955, when Frank Gardner and Louis Diamond reported four adult women who developed spontaneous bruising lesions several months after sustaining a trauma. [1]ung are more commonly affected.They develop cutaneous symptoms characterized by recurrent flare-ups of ecchymotic painful episodes unrelated to haematologic or coagulation defects.Other unspecific as well malaise, abdominal pain, headache, arthralgia,...
Pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome, the proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1)-associated myeloid-related proteinemia inflammatory (PAMI) syndrome are two distinct clinical conditions caused by heterozygous mutations of PSTPIP1 gene. While skin joint involvements shared both conditions, PAMI is characterized hepatosplenomegaly, pancytopenia, growth failure. Kidney involvement exceptional in PSTPIP1-mediated disorders. The missense...
Hepatitis C virus (HCV) variability is mainly attributed to the ability of respond host immune pressure, acting as a driving force for evolution quasispecies. This study was aimed at studying changes in HVR-1 heterogeneity and HCV quasispecies HIV/HCV-coinfected patients according pattern response highly active antiretroviral therapy (HAART). Sixteen harbouring genotype 1 who had been on HAART least year, 8 showing increasing CD4 + T-cell counts (immunological responders) stable or...
Ofatumumab is an anti-CD20 humanized monoclonal antibody utilized in the treatment of several clinical conditions resistant to other treatments. In spite there was a general expectation that ofatumumab less toxic compared rituximab, side effects have been reported resemble those its chimeric precursor. Here, we describe first case associate lung injury occurring 14-year-old boy affected by nephrotic syndrome dependent prednisone plus cyclosporine A who had treated with dose drug (1500 mg/173...
Abstract Aim Drowning is a leading cause of unintentional death. Ongoing efforts are dedicated to preventing these tragic incidents. Our aim was evaluate whether demographic, environmental and epidemiological characteristics drowned children influence their prognosis. Methods Single‐centre retrospective study spanning 12 years. Each patient's record included: age, sex, place residence, presence siblings, season incident, location event, associated trauma, loss consciousness, need for...
Background Red ear syndrome (RES), first described by Lance in 1996 an adult series, may be primary or associated with headache syndromes, upper cervical disorders vascular anomalies. Clinically the disease is characterised recurrent episodes of reddening and burning pain auricle, usually elicited different triggers. The prevalence RES paediatric age group remains poorly understood. Several therapeutic approaches have been tried heterogeneous clinical response. Case results We report a...
Background and Clinical Significance: The use of point-of-care ultrasound (POCUS) in emergency departments is rapidly growing due to its ability provide immediate accurate diagnostic information at the bedside. Furthermore, it can precise rapid on location multidistrict effusions patients with suspected lymphatic decompensation. Case Presentation: This unique clinical case report describes a patient who presented massive, chylous effusion secondary acute insufficiency, rare challenging...
<h3>Background</h3> Vaccine-preventable diseases are again emerging in our population after anti-vaccine campaign has started. In autoinflammatory (AID), vaccine triggered-disease is a well known phenomenon for Hyper-IgD/Mevalonate-Kinase Deficiency (MKD). CAPS, severe flares have been experienced pneumococcus vaccine, while PFAPA patients did not achieve sufficient and protective levels of antibodies. This evidence raised doubts physicians families about the safety vaccines....
Recurrent pericarditis represents an important complication of acute pericarditis. Therapeutic approach during recurrences consists NSAID administration. However steroid is often necessary to control disease flares. IL-1 inhibitors efficacy has been anecdotally described as effective in the steroid-dependent and Colchicine-resistant patients.
Recurrent pericarditis represents an important complication of acute pericarditis. Therapeutic approach during recurrences consists NSAID (non-steroidal anti-inflammatory drugs) administration. However steroid is often necessary to control disease flares. IL-1 inhibitors efficacy has been anecdotally described as effective in the steroid-dependent and colchicine-resistant patients.
Abstract Objective To assess the most frequent clinical features of Multisystem Inflammatory Syndrome in children (MIS-C) at presentation to Emergency Department (ED) a large multicenter cohort patients, order define useful tools for timely diagnosis. Methods Clinical and laboratory characteristics were retrospectively reviewed 210 MIS-C patients from 18 Italian pediatric EDs. We assessed correlations between parameters compared different age (≤5 years >5 years). Results Fever was main...