A5052432715- Kawasaki Disease and Coronary Complications
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Streptococcal Infections and Treatments
- Ultrasound in Clinical Applications
- Cardiac electrophysiology and arrhythmias
- Respiratory Support and Mechanisms
- Appendicitis Diagnosis and Management
- COVID-19 and Mental Health
- Cardiac Arrhythmias and Treatments
- Viral gastroenteritis research and epidemiology
- Emergency and Acute Care Studies
- Pneumonia and Respiratory Infections
- Poisoning and overdose treatments
- Pancreatitis Pathology and Treatment
- Pharmaceutical studies and practices
- Inflammasome and immune disorders
- Neonatal and fetal brain pathology
- Burn Injury Management and Outcomes
- Dermatological diseases and infestations
- Mechanical Circulatory Support Devices
- Infection Control and Ventilation
- Long-Term Effects of COVID-19
- Cardiovascular Conditions and Treatments
Santobono Children's Hospital
2012-2025
Ospedale Buon Consiglio Fatebenefratelli
2018
Ospedale D. Cotugno
2014
Azienda di Rilievo Nazionale ed Alta Specializzazione
2013
University of Naples Federico II
1994
Objectives: The aim of this study was to assess the impact COVID-19 pandemic and population lockdown on pediatric ED consultations. Methods: A cross-sectional emergency department consultations before during current (March -May 2019 vs March - May 2020) performed in two hospitals Campania region (Southern Italy), i.e. Salerno University Hospital (Salerno) Pediatric Regional Referral Emergency Hub "AORN Santobono-Pausillipon" (Naples). Results: 29,368 consecutive patients (13,430 females;...
Objectives: Animal-related injuries (ARIs) represent a common reason for emergency department (ED) visits in children. Limited data regarding treatment Italian EDs are available. The aims of the study were to assess epidemiological features these patients and investigate association between their characteristics therapeutic approaches, particularly antibiotic prescription. Materials Methods: Patients presenting 13 pediatric from 11 regions because ARIs prospectively enrolled 20 months....
From 9 March to 3 May 2020, lockdown was declared in Italy due the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Our aim evaluate how SARS-CoV-2 pandemic and related preventive strategies affected pediatric emergency rooms (ERs) during this period. We performed a retrospective cohort multicenter study, comparing period corresponding 2019. examined 15 Italian ERs terms of visit rates, specific diagnoses (grouped as air communicable diseases non-air diseases), triage...
Several reports highlighted how public health measures aimed at limiting severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) circulation have likely contributed to reducing the of other viruses, particularly during first year COVID-19 pandemic. We evaluated epidemiology infections in a large cohort hospitalized children third pandemic (2021−2022). retrospectively analyzed data from records (<14 years) for between 1 July 2021 and 31 March 2022. A total 1763 panels were collected....
Multisystem inflammatory syndrome in children (MIS-C) is a rare, severe complication of COVID-19. A better knowledge immunological, cellular, and genetic characteristics MIS-C could help understand the pathogenesis disease contribute to identifying specific diagnostic biomarkers develop targeted therapies. We studied 37 at hospital admission 24 healthy controls analyzing serum cytokines (IFN-α, IFN-β, IFN-γ, IL-6, IL-10, IL-17A, IL-12p70 TNF), lymphocyte populations by flow cytometry 386...
Most fire-related deaths are attributable to smoke inhalation rather than burns. The of fire smoke, which contains not only carbon monoxide but also a complex mixture gases, seems be the major cause morbidity and mortality in victims, mainly enclosed spaces. Cyanide gas exposure is quite common during inhalation, cyanide present blood victims most cases may play an important role death by inhalation. poisoning may, however, difficult diagnose treat. In these children, hydrogen source...
<h3>Objective</h3> To evaluate the risk of upper gastrointestinal complications (UGIC) associated with drug use in paediatric population. <h3>Methods</h3> This study is part a large Italian prospective multicentre study. The population included children hospitalised for acute conditions through emergency departments eight clinical centres. Patients admitted UGIC (defined as endoscopically confirmed gastroduodenal lesions or clinically defined haematemesis melena) comprised case series;...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may present with a wide variety of symptoms, including neurological manifestations. We investigated clinical, demographic, laboratory, neurophysiological and imaging characteristics SARS-CoV-2-positive children seizures analyzed differences between admitted during the periods prevalent circulation Alpha/Delta Omicron variants, respectively. Patients’ were according to presence or absence then SARS-CoV-2 variants. Five-hundred four...
Liver and pancreatic involvement in children with Multisystem Inflammatory Syndrome related to SARS-CoV-2 (MIS-C) has been poorly investigated so far. We reviewed a cohort of MIS-C patients analyze the prevalence acute liver injury (ALI) their correlation clinical outcomes. Demographic, clinical, laboratory imaging features at admission during hospital stay were prospectively collected. Fifty-five (mean age 6.5 ± 3.7 years) included. At admission, 16 showed ALI 5 had increased total serum...
Endothelial hyperinflammation and vasculitis are known hallmarks of acute COVID-19 multisystem inflammatory syndrome in children (MIS-C). They due to the direct effect virus on endothelial cells enhanced by pro-inflammatory modulators may cause venous/arterial thrombosis. Therefore, it is essential identify patients with damage early order establish specific therapies. We studied monocyte chemoattractant protein 1 (MCP-1), perinuclear anti-neutrophil cytoplasmic antibodies (pANCA), vascular...
Acute pharyngitis is a frequent reason for primary care or emergency unit visits in children. Most available data on management come from studies that demonstrate an underuse of microbiological tests, tendency to over-prescribe antibiotics and risk antimicrobial resistance increase. However, comprehensive understanding acute units lacking. This study aimed investigate the frequency rapid antigen test use diagnose pharyngitis, as well other diagnostic approaches, therapeutic attitude,...
To evaluate the effectiveness of seasonal influenza vaccine in preventing Emergency Department (ED) visits and hospitalisations for like illness (ILI) children.We conducted a test negative case-control study during 2011-2012 2012-2013 seasons. Eleven paediatric hospital/wards seven Italian regions participated study. Consecutive children visiting ED with an ILI, as diagnosed by doctor according to European Centre Disease Control case definition, were eligible Data collected from trained...
Background: Multisystem inflammatory syndrome in children (MIS-C) is a disease temporally related to severe acute respiratory coronavirus 2 (SARS-CoV-2) and it characterized by fever, conjunctival injections, rash, gastrointestinal symptoms, cardiovascular complications. We evaluated the clinical presentation, laboratory findings, imaging features, therapeutic interventions, hospital course of monocentric cohort, we analyzed these findings according two age groups. Methods: Patients with...
We hypothesized that-as in other common pediatric conditions-acute appendicitis (AA) could be complicated by acute kidney injury (AKI). aimed to investigate the prevalence of, and factors associated with AKI a cohort of patients AA. retrospectively collected data 122 children (63.9% male gender; mean age 8.6 ± 2.9 years; range: 2.2-13.9 years) hospitalized for was defined according Kidney Disease/Improving Global Outcomes creatinine criteria. considered basal serum value as estimated Hoste...
Endothelial-cell-specific molecule-1 (ESM-1) also called endocan is a well-known biomarker for detecting inflammation, endothelial dysfunction (ED), and cardiovascular (CV) risk in COVID-19 patients. Upon SARS-CoV-2 infection, small percentage of children develop Multisystem Inflammatory Syndrome (MIS-C). Whether can be used as MIS-C unknown. In this study, we assessed ESM-1 levels (n = 19) healthy controls (HC; n 17). We observed significant increase serum vs HC (p 0.0074). addition, ROC...
Previously, we demonstrated an 81% reduction in pediatric Emergency Room (ER) visits Italy during the strict lockdown due to SARS-CoV-2 pandemic. Since May 2020, measures were relaxed until 6 November when a was patchily reintroduced. Our aim evaluate impact of on ER Italy. We performed retrospective multicenter study involving 14 Italian ERs. compared total from 24 September 2020 with those corresponding timeframe 2019. evaluated 17 specific diagnoses grouped air communicable and non-air...
The pathogenesis of the novel described multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease (KD) is still debated as it not clear if they are same or different nosological entities. However, for both diseases a rapid unequivocal diagnosis mandatory to start therapy before onset severe complications. In this study, we aimed evaluate white cell populations MIS-C KD potential markers discriminate between two diseases.We studied by flow cytometry 46 28 patients comparison...