A5109838563- Orthopedic Infections and Treatments
- Bone fractures and treatments
- Immunodeficiency and Autoimmune Disorders
- Orthopedic Surgery and Rehabilitation
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Osteomyelitis and Bone Disorders Research
- Infectious Diseases and Tuberculosis
- Hip and Femur Fractures
- Knee injuries and reconstruction techniques
- Eosinophilic Esophagitis
- Elbow and Forearm Trauma Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Medical and Biological Sciences
- Blood disorders and treatments
- T-cell and B-cell Immunology
- Musculoskeletal Disorders and Rehabilitation
- Pelvic and Acetabular Injuries
- Food Allergy and Anaphylaxis Research
- Tuberculosis Research and Epidemiology
- Eosinophilic Disorders and Syndromes
- Cell Adhesion Molecules Research
- Immune responses and vaccinations
- Shoulder Injury and Treatment
- thermodynamics and calorimetric analyses
Bnai Zion Medical Center
2019-2024
McMaster University
2023-2024
University of Toronto
2021-2023
Hospital for Sick Children
2021-2023
SickKids Foundation
2021-2023
McMaster Children's Hospital
2023
Rambam Health Care Campus
2013-2022
Tel Aviv University
2016
Sheba Medical Center
2016
Technion – Israel Institute of Technology
2016
Merkel cell carcinoma (MCC) is a rare aggressive skin tumor associated with high mortality rate. The present study evaluated the role of fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) in subsequent management patients MCC.A total 101 consecutive F-FDG PET/CT studies 46 MCC (28 men, 68±15.4 years) were retrospectively and clinical care was documented.There 40 positive (40%) 28 (61%); these, 33 (33%) 27 (59%) showed metastatic disease. Fifty-two (51%) 23/46 (50%) negative....
STAT1 gain-of-function (GOF) is an immune dysregulatory disorder with poorly studied genotype-phenotype correlation, impeding prognostication and early intervention. Given previous mechanistic studies, as well anecdotal clinical reports, we sought to systematically determine whether DNA-binding domain (DBD) mutations in result a different phenotype than other gene domains.Negative prognostic features previously identified by the International GOF Study Group (invasive infections,...
Abstract Background Protracted febrile myalgia syndrome (PFMS) is a rare complication of Familial Mediterranean fever (FMF). The diagnosis based on clinical symptoms and often challenging, especially when PFMS the initial manifestation FMF. aim this report was to describe magnetic resonance imaging (MRI) findings in pediatric patients with PFMS. Results There were three girls two boys ranging age from 6 months 16 years, all ancestry. Three had high-grade fever, elevated inflammatory markers....
Background STAT1 gain-of-function (GOF) is a primary immune dysregulatory disorder marked by wide infectious predisposition (most notably chronic mucocutaneous Candidiasis), autoimmunity, vascular disease and malignant predisposition. While atopic features have been described in some GOF patients, they are not considered predominant feature of the disease. Additionally, while eosinophilic gastrointestinal infiltration has reported cases, this always context pre-existing oropharyngeal and/or...
Background: The Forkhead box protein N1 (FOXN1) is a key regulator of thymic epithelial development, and its complete deficiency leads to nude-severe combined immunodeficiency (SCID) phenotype. More recently, heterozygous mutations in FOXN1 have been linked with syndrome congenital lymphopenia wide clinical spectrum, most cases being caused by missense mutations. Aim: To broaden the genotypic phenotypic spectrum deficiency. Methods: Case report patient haploinsufficiency due novel...
The authors describe Ilizarov's method for the treatment of infected tibial pseudarthrosis and reconstruction diaphyseal bone defects. This technique was used on 37 patients: 29 cases consisted non-unions without defect 8 with consequent between 2 15 cm. Results are variable less satisfactory than those published by Ilizarov himself or other authors. late results better in (79 % consolidation, 68 cure infection) extensive (44 55 infection). must be considered as very demanding patient also...
Introduction: Hyper IgM (HIGM) syndrome is an inborn error of immunity (IEI) that occurs due to defects in immunoglobulin class switch recombination (Ig-CSR). HIGM typically presents with recurrent infections early childhood, and often characterized on investigation decreased IgG, IgA, IgE titres, alongside normal or elevated IgM. A common cause a disruption the CD40-CD40 ligand (CD40L) interaction triggers Ig-CSR, which variants CD40 are much rarer than those CD40L. We present case...
Introduction: Agammaglobulinemia is a primary immunodeficiency characterized by absent B cells and originates from X-linked or autosomal mutations affecting cell maturation. While the most common agammaglobulinemia X-linked, one well-documented site of recessive within immunoglobulin μ heavy chain protein, encoded IGHM gene. Such variants frequently result in clinical presentations recurrent bacterial infections early life. Aim: To describe case five-year-old female with resulting novel...
Background: The escalating resistance of uropathogens in pediatric febrile urinary tract infection (F-UTI) is a global concern. This study examined changing trends F-UTI epidemiology and patterns among Israeli inpatients over decade. Methods: Demographic, clinical, laboratory data for children between 3 months 18 years old with UTI from 2010 to 2021 were retrieved electronic medical records. Results: A total 761 cases identified (702 females, mean age 43 months). Escherichia coli was the...
Introduction: DiGeorge syndrome is a heterogenous disorder with various clinical presentations. Common features include thymic hypoplasia, T cell lymphopenia, conotruncal heart defects, facial dysmorphism, cleft palate, developmental delay, and hypoparathyroidism. The severity of this condition varies, however typical presentation includes congenital defects characteristic features. Isolated hypocalcemia in rarely seen neonates but rather as the sole manifestation older teenagers or adults....
Background: Eosinophilic gastrointestinal disease (EGID) is an umbrella term for a heterogeneous group of disorders affecting the GI tract. In contrast to relatively common eosinophilic esophagitis (EoE), gastroenteritis (EGE) remains poorly understood in terms both its pathophysiology and genetic etiology, while treatment options remain limited. Aim: To expand genotypic spectrum EGE describe our long-term experience with ketotifen. Methods: Case report patient followed by team over 27...