A5016943200- Inflammasome and immune disorders
- Autoimmune and Inflammatory Disorders Research
- Kawasaki Disease and Coronary Complications
- Adolescent and Pediatric Healthcare
- Systemic Lupus Erythematosus Research
- Streptococcal Infections and Treatments
- Vasculitis and related conditions
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Acute Lymphoblastic Leukemia research
- IL-33, ST2, and ILC Pathways
- Autoimmune and Inflammatory Disorders
- Dermatological and COVID-19 studies
- Ion Channels and Receptors
- Eosinophilic Esophagitis
- Cardiovascular Issues in Pregnancy
- Osteomyelitis and Bone Disorders Research
- Chronic Lymphocytic Leukemia Research
- Antimicrobial Resistance in Staphylococcus
- Orthopedic Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Microscopic Colitis
- Atherosclerosis and Cardiovascular Diseases
- Healthcare and Venom Research
- Hair Growth and Disorders
- Gout, Hyperuricemia, Uric Acid
Schneider Children's Medical Center
2019-2025
Tel Aviv University
2019-2025
Meyer Children's Hospital
2023
Istituti di Ricovero e Cura a Carattere Scientifico
2023
University of Florence
2023
Tokyo Women's Medical University
2023
Yokohama City University
2023
Penn State Milton S. Hershey Medical Center
2022
University of California, San Francisco
2021
Hackensack University Medical Center
2021
Objectives Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children. Nonsteroidal anti-inflammatory drugs (NSAIDs) and intra-articular corticosteroid injections are first-line therapy for oligoarticular JIA. NSAIDs Adverse events (AEs) include gastrointestinal ulcers/bleeding impaired renal function. The prescribed JIA ibuprofen naproxen. However, direct comparison between these lacking. We aimed to compare efficacy safety of versus naproxen
Alopecia areata may occur at any age, though usually before the age of 20 years. Treatment often consists systemic steroids administered as high-dose bolus infusions. This study sought to investigate effectiveness and side effects intravenous pulse corticosteroids in children with alopecia identify prognostic factors for successful treatment.Patients treated 2001-2008 day care unit a tertiary pediatric medical center were identified by computerized file search clinical treatment outcome data...
The European League Against Rheumatism and American College of Rheumatology 2019 (EULAR/ACR-19) criteria for the diagnosis SLE were recently published, with stated goal maintaining level sensitivity raising specificity classification in adults. aim this study is to examine their application juvenile (jSLE) patients.In multicentre charts jSLE patients from three tertiary medical centres reviewed compared non-jSLE diagnosis. Paediatric rheumatologists, blinded original diagnosis, diagnosed all...
Our aims were to clinically and epidemiologically characterize rheumatic fever (RF) in the current era Israel. Although there has been a steady decline incidence of RF western world, evidence disease resurgence developed countries continues be published. The paucity recent epidemiological data prompted our study.Medical files retrospectively reviewed for all children with tertiary pediatric university-affiliated hospital from 1993 2017. Main outcome measures patients related characteristics,...
Abstract Objectives Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease. Intra-articular corticosteroids joint injection (IAJI), with triamcinolone hexacetonide (TH) or acetonide (TA), an effective additional treatment for oligo and polyarticular JIA. Previous studies have shown benefits of TH over TA; however, TA still used in many pediatric rheumatology centers. Our unit has experience both regimens, therefore we aimed to compare efficacy safety versus JIA...
Objective Cryopyrin‐associated periodic syndromes (CAPS), also known as NLRP3‐associated autoinflammatory diseases, are a spectrum of rare diseases caused by gain‐of‐function variants in the NLRP3 gene, resulting inflammasome hyperactivation and dysregulated release interleukin‐1β (IL‐1β). Many patients with CAPS develop progressive sensorineural hearing loss (SNHL) because cochlear autoinflammation, which may be sole manifestation cases. This study was undertaken to establish suspected...
Abstract Background Protracted febrile myalgia syndrome (PFMS) is a rare complication of Familial Mediterranean fever (FMF). The diagnosis based on clinical symptoms and often challenging, especially when PFMS the initial manifestation FMF. aim this report was to describe magnetic resonance imaging (MRI) findings in pediatric patients with PFMS. Results There were three girls two boys ranging age from 6 months 16 years, all ancestry. Three had high-grade fever, elevated inflammatory markers....
Since the development of COVID-19 vaccines, more than 4.8 billion people have been immunized worldwide. Soon after vaccinations were initiated, reports on cases myocarditis following second vaccine dose emerged. This study aimed to report our experience with adolescent and young adults who developed post-COVID-19 compare these patients a cohort acquired pediatric inflammatory multisystem syndrome (PIMS/PIMS-TS) infection.We collected reported vaccination (Pfizer mRNA BNT162b2) from all...
Abstract Objective It is common knowledge among clinicians who treat PFAPA (Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis) patients that emotional stress can trigger attacks similarly to other autoinflammatory diseases. However, it has never been proved scientifically. Our aim was examine whether serves as a for attacks. Methods Patients aged 3-12 years, with active PFAPA, from two Israeli medical centers were enrolled this study. Patient's parents reached via phone calls in...
Abstract Objective Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is the most common periodic fever in children; by definition, episodes occur every 2 to 8 weeks. However, a subset of our patients, we noticed higher frequency attacks, less than weeks, which refer as extreme PFAPA (ePFAPA). This group consisted patients who were upon presentation PFAPA, those became after initiation abortive corticosteroid treatment. We aimed characterize demographic...
To identify predictors of a severe clinical course multisystem inflammatory syndrome in children (MIS-C), as defined by the need for inotropic support.This retrospective study included patients diagnosed with MIS-C (according to CDC definition) nine Israeli and one US medical centre between July 2020 March 2021. Univariate multivariate regression models assessed odds ratio (OR) demographic, clinical, laboratory imaging variables during admission hospitalization disease.Of 100 patients, 61...
Abstract Background Granulomatosis with polyangiitis (GPA) is an anti-neutrophilic cytoplasmic antibody-associated vasculitis affecting small to medium-sized vessels and involves most commonly the kidneys respiratory tract. Skin involvement can be seen in up 50% of children GPA initial presenting symptom 7.7%. Pyoderma gangrenosum (PG)-like ulcers are rarely described as a skin manifestation very few cases have been reported previously children. Case presentation We describe 3 new pediatric...
<h3>Background</h3> Familial Mediterranean fever (FMF) is the most common autoinflammatory disease. Without therapy, it may lead to development of secondary amyloidosis. Treatment with colchicine leads long-term remission in ~70% patients. 5% are resistant therapy (crFMF) and be treated monthly dose canakinumab (anti IL-1beta). However, colchicine, only drug proved prevent Canakinumab immunosuppressive as well expensive. <h3>Objectives</h3> To compare on demand (COD) dosage policy vs. fixed...
Abstract Background : Granulomatosis with polyangiitis (GPA) is an anti-neutrophilic cytoplasmic antibody-associated vasculitis affecting small to medium-sized vessels and involves most commonly the kidneys respiratory tract. Skin involvement can be seen in up 50% of children GPA initial presenting symptom 7.7%. Pyoderma gangrenosum (PG)-like ulcers are rarely described as a skin manifestation very few cases have been reported previously children. Case presentation We describe 3 new...
Background: The fact that mental state may serve as a trigger for attacks of periodic fever diseases is known in Familial Mediterranean (FMF). There lack information regarding the role emotional triggers PFAPA attacks. Objectives: To examine whether distress Methods: Enrolled were patients with active PFAPA, from two Israeli medical centers. Researchers contacted their parents by phone occasions: a. within weeks returning to school after first COCID-19 lockdown; b. during summer vacation...
Background: The “European League Against Rheumatism” and “American College of Rheumatology” 2019 (EULAR/ACR-19) criteria for the diagnosis Systemic Lupus Erythematosus (SLE) were recently published, with stated goal maintaining level sensitivity raising specificity classification SLE in adults. Objectives: We aimed to examine function new EULAR/ACR-19 a population children compare them SLICC-12 ACR-97 criteria. Methods: In this multicenter study charts jSLE patients from three tertiary...
ABSTRACT Cryopyrin-associated periodic syndromes (CAPS) also known as NLRP3-associated auto-inflammatory diseases, are a spectrum of rare diseases caused by gain-of-function mutations in the NLRP3 gene, resulting inflammasome hyper-activation and dysregulated release Interleukin-1 β (IL-1 ). Many patients with CAPS develop progressive sensorineural hearing loss (SNHL) due to cochlear auto-inflammation which, cases, may be sole manifestation. This study was undertaken establish suspected...
<h3>Background</h3> Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome, is an interferonopathy caused by proteasomal dysfunction. Clinical characteristics include early onset inflammation, nodular rashes, hepatosplenomegaly, myositis, panniculitis, basal ganglion calcifications. CANDLE associated syndromes are gouped into the proteasome-associated autoinflammatory (PRAAS). Our patient presented at age of 3 months features strongly...