A5059169622- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Inflammatory Myopathies and Dermatomyositis
- Rheumatoid Arthritis Research and Therapies
- Acute Lymphoblastic Leukemia research
- Eosinophilic Disorders and Syndromes
- Ocular Diseases and Behçet’s Syndrome
- Kawasaki Disease and Coronary Complications
- Retinal and Optic Conditions
- Systemic Lupus Erythematosus Research
- Renal Diseases and Glomerulopathies
- Musculoskeletal synovial abnormalities and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Vector-borne infectious diseases
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Adrenal Hormones and Disorders
- Asthma and respiratory diseases
- Dermatological diseases and infestations
- Primary Care and Health Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Vitamin D Research Studies
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Pediatric health and respiratory diseases
Connecticut Children's Medical Center
2016-2024
University of Connecticut
2016-2024
Duke University
2024
University of Alabama at Birmingham
2022
Pediatrics and Genetics
2021
Hospital for Special Surgery
2021
Hartford Financial Services (United States)
2021
Amgen (United States)
2021
Cornell University
2021
Weill Cornell Medicine
2021
Objective. Children often develop arthritis secondary to Lyme disease; however, optimal treatment of in pediatric patients remains ill-defined. We sought characterize the outcomes a large cohort children with treated using approach recommended by American Academy Pediatrics and Infectious Diseases Society America. Methods. Medical records seen rheumatologists at tertiary care children’s hospital from 1997 2007 were reviewed. Patients classified antibiotic responsive or refractory based on...
Rheumatoid arthritis is associated with an excess of agalactosylated (G0) IgG that considered relatively proinflammatory. Assessment this association in juvenile idiopathic (JIA) complicated by age-dependent glycan variation. The aim study was to conduct the first large-scale survey glycans healthy children and patients JIA, a focus on early childhood, time peak JIA incidence.IgG from disease-modifying antirheumatic drug-naive were characterized using high-performance liquid chromatography....
To highlight the opportunities and challenges of developing implementing performance outcome measures in rheumatology for accountability purposes.We constructed a hypothetical measure to demonstrate benefits designing quality that assess patient outcomes. We defined data source, cohort, reporting period, period at risk, outcome, attribution, risk adjustment, reliability validity, approach. discussed specific fields where patients have predominantly chronic, complex, ambulatory care-sensitive...
Abstract Background Despite new and better treatments for juvenile dermatomyositis (JDM), not all patients with moderate severity disease respond adequately to first-line therapy. Those refractory remain at higher risk glucocorticoid-related complications. Biologic disease-modifying antirheumatic drugs (DMARDs) have become part of the arsenal JDM. However, prospective comparative studies commonly used biologics are lacking. Methods The Childhood Arthritis Rheumatology Research Alliance...
Objective The objective was to develop consensus treatment plans (CTPs) for patients with refractory moderately severe juvenile dermatomyositis (JDM) treated biologic disease‐modifying antirheumatic drugs (bDMARDs). Methods Biologics Workgroup of the Childhood Arthritis and Rheumatology Research Alliance JDM Committee used case‐based surveys, framework, nominal group technique produce bDMARD CTPs JDM. Results Four were proposed: tumor necrosis factor α (TNFα) inhibitor (adalimumab or...
Objective We examine levels of candidate blood‐based biomarkers (CBBs) in patients with juvenile idiopathic arthritis (JIA) treated tofacitinib. Methods Patients JIA who participated clinical trial NCT02592434 received tofacitinib from baseline to week 18. Serial serum samples were assayed for CBBs (S100A8/9, S100A12, interleukin‐18 [IL‐18], amyloid A, resistin, vascular endothelial growth factor, angiopoietin‐1, angiopoietin‐2, matrix metalloproteinase 8 [MMP8], MMP2, tissue inhibitor...
Background: Tofacitinib is an oral JAK inhibitor that being investigated for JIA. Objectives: To assess tofacitinib efficacy and safety in JIA patients (pts). Methods: This was a Phase 3, randomised, double-blind (DB), placebo (PBO)-controlled withdrawal study pts aged 2−<18 years with polyarticular course (pcJIA), PsA or ERA ( NCT02592434 ). In the 18-week open-label Part 1, received weight-based doses (5 mg BID lower). Pts ≥JIA ACR30 response at Week (W)18 were randomised 1:1 DB 2...
Abstract Background Global disease activity scores (gVAS) capture patient or family (PF) and physician (MD) assessments of disease. This study sought to measure discordance between PF MD global in juvenile dermatomyositis (JDM), determine factors associated with discordance. Methods Patients JDM were included from the Childhood Arthritis Rheumatology Research Alliance (CARRA) Legacy Registry ( N = 563). gVAS assessed for discordance, defined as a ≥ 2-point difference. Factors discordant...
A standardized set of quality measures for juvenile idiopathic inflammatory myopathies (JIIM) is not in use. Discordance has been shown between the importance ascribed to patients and families physicians. The objective this study was assess compare various aspects high care with JIIM their healthcare providers, aid future development comprehensive measures. Surveys were developed by members Childhood Arthritis Rheumatology Research Alliance (CARRA) Juvenile Dermatomyositis Workgroup through...
Mrosak, Justine MD; Banasiak, Kenneth Edelheit, Barbara Lapin, Craig Tory, Heather Collins, Melanie Sue MDAuthor Information
Ocular point-of-care ultrasound has been used to assess for intraocular pathology, including retinal and vitreous detachment. We describe a pediatric patient whose initial examination appeared be consistent with bilateral posterior detachment but who was ultimately diagnosed intermediate uveitis.
Ambler, Lauren; Tory, Heather; Carroll, Christopher; Salonia, Rosanne Author Information
A 2-month-old infant Hispanic female with failure to thrive and choking episodes was admitted progressive worsening of respiratory effort, paroxysmal coughing, hypoxemia. She required prolonged mechanical ventilation post-pyloric feeding for concern aspiration no marked improvement chest radiogram or CT findings. Lung biopsy performed remarkable lymphocytic infiltration but without a definite diagnosis. Genetic testing identified unique heterozygous mutation in the COPA gene. started on...