A5055167526- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Spondyloarthritis Studies and Treatments
- Systemic Lupus Erythematosus Research
- Musculoskeletal synovial abnormalities and treatments
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Biosimilars and Bioanalytical Methods
- Orthopedic Infections and Treatments
- HER2/EGFR in Cancer Research
- Viral Infections and Immunology Research
- Bone and Joint Diseases
- Orthopedic Surgery and Rehabilitation
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac, Anesthesia and Surgical Outcomes
- Hip and Femur Fractures
- Orthopaedic implants and arthroplasty
- S100 Proteins and Annexins
- Biomarkers in Disease Mechanisms
- Hepatitis C virus research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Sarcoidosis and Beryllium Toxicity Research
Diakonhjemmet Hospital
2016-2025
University of Oslo
2010-2025
Institute for Rheumatic Diseases (Japan)
2023
Okayama University
2023
University of the West of England
2023
University Hospitals Bristol NHS Foundation Trust
2023
University Hospitals Bristol and Weston NHS Foundation Trust
2023
Kochi Medical School Hospital
2023
University of Leeds
2023
NIHR Leeds Musculoskeletal Biomedical Research Unit
2023
To determine whether a treatment strategy based on structured ultrasound assessment would lead to improved outcomes in rheumatoid arthritis, compared with conventional strategy. Multicentre, open label, two arm, parallel group, randomised controlled trial. Ten rheumatology departments and one specialist centre Norway, from September 2010 2015. 238 patients were recruited between April 2013, of which 230 (141 (61%) female) received the allocated intervention analysed for primary outcome. The...
Objectives One goal of remission in rheumatoid arthritis (RA) is to halt joint damage. The authors assessed the progression radiographic damage among RA patients by new ACR/EULAR criteria (Boolean approach) compared with thresholds for simplified disease activity index (SDAI), clinical (CDAI) and score based on 28 joints C-reactive protein (DAS28-CRP) an observational cohort, evaluated relationship between time Methods 535 underwent physical examination laboratory assessment at baseline, 1 2...
Objective. The Outcome Measures in Rheumatology (OMERACT) Rheumatoid Arthritis (RA) Magnetic Resonance Imaging (MRI) scoring system (RAMRIS), evaluating bone erosion, marrow edema/osteitis, and synovitis, was introduced 2002, is now the standard method of objectively quantifying inflammation damage by MRI RA trials. objective this paper to identify subsequent advances based on them, provide updated recommendations for RAMRIS. Methods. studies relevant RAMRIS technical scientific were...
To compare the presentation of seropositive and seronegative early rheumatoid arthritis (RA) in disease-modifying antirheumatic drug (DMARD)-naïve patients classified according to 2010 American College Rheumatology (ACR)/European League Against Rheumatism (EULAR) criteria.All had symptom duration from first swollen joint <2 years were DMARD naïve with an indication for treatment. Patients stratified as (positive factor (RF)+ and/or anticitrullinated peptide antibody (ACPA)+) or (RF- ACPA-),...
Abstract Objectives To explore mortality and causes of death among Norwegian patients with RA, PsA axial spondyloarthritis (axSpA) compared the general population by conducting a nationwide registry-based cohort study. Methods Patients axSpA were identified from Patient Registry based on ICD-10 codes between 2008 2017. Using age as time variable, all-cause cause-specific estimated 2010 2017 Kaplan–Meier estimator cumulative incidence competing risk method, respectively. Sex-, education...
Including carbon footprint as an end point in randomized, controlled trials could help clinicians, regulators, and policymakers understand the environmental effects of medical interventions.
Objectives MRI scoring systems for hand osteoarthritis (HOA) are currently not available. The present work proposes the Oslo HOA (OHOA-MRI) score and examines intrareader inter-reader reliability. Methods Relevant features were included in initial version of OHOA-MRI after literature review informal group discussions. After a training session two calibration exercises (with three readers), with low reliability and/or prevalence excluded, feature definitions/gradings improved. In exercise 3...
Objective. The aim of this multireader exercise was to assess the reliability and sensitivity change psoriatic arthritis magnetic resonance imaging score (PsAMRIS) in PsA patients followed for 1 year. Methods. MRI acquired from 12 with before initiation treatment after months. MR images were scored according PsAMRIS (for synovitis, tenosynovitis, periarticular inflammation, bone marrow edema, erosion, proliferation) under standardized conditions, unknown chronological order....
Objective. To develop and validate a magnetic resonance imaging (MRI) method of assessment joint space narrowing (JSN) in rheumatoid arthritis (RA). Methods. Phase A: JSN was scored 0–4 on MR images 5 RA patients 3 controls at 15 wrist sites 2nd–5th metacarpophalangeal (MCP) joints by 8 readers (7 once, one twice), using preliminary scoring system. B: Image review, discussion, consensus definition, revised C: 4 were system (4 results compared with radiographs [Sharp-van der Heijde (SvdH)...
To develop and test the interreader reliability of OMERACT Hand Osteoarthritis Magnetic Resonance Scoring System (HOAMRIS) for assessment structural inflammatory hand OA features in interphalangeal joints.The HOAMRIS was developed through an iterative process. Selection their scaling agreed upon consensus by members Imaging (MRI) Task Force, using Oslo (OA) MRI Score system as a template. Two exercises were performed, which 6 4 readers participated, respectively. After first exercise, atlas...
Calprotectin is an inflammatory marker of interest in rheumatoid arthritis (RA). We evaluated whether the level calprotectin was associated with disease activity, and if it predictive treatment response radiographic progression patients early RA.Plasma from disease-modifying antirheumatic drug (DMARD)-naïve RA fulfilling 2010 American College Rheumatology/European League Against Rheumatism classification criteria symptom duration <2 years analysed for at baseline, after 1, 3 12 months. All...
To examine all-cause and cardiovascular disease (CVD) mortality in consecutive cohorts of patients with incident RA, compared population comparators.The Oslo RA register inclusion criteria were diagnosis (1987 ACR criteria) residency Oslo. Patients onset 1994-2008 10 matched comparators for each case linked to the Norwegian Cause Death Registry. Hazard ratios CVD calculated 5, 10, 15 20 years observation using stratified cox-regression models. Mortality trends estimated by multivariate...
Objectives Recent studies suggest that implementation of the 2010 American College Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for rheumatoid arthritis (RA) leads to higher inflammatory activity in seronegative compared with seropositive patients at time diagnosis. Our aim was compare disease course and classified according criteria. Methods DMARD-naïve RA fulfilling were included treat-to-target ARCTIC trial followed 24 months. We stratified as...
Inflammation and anti-inflammatory treatments might influence the risk of diabetes. The objective this study was to assess factors associated with incident diabetes in rheumatoid arthritis (RA).The population consisted RA patients from a multi-center cohort study, Corrona. To disease modifying antirheumatic drug (DMARD) exposure, we assessed five mutually exclusive DMARD groups. Additionally, body mass index (BMI, <25, 25-30, >30 kg/m2) glucocorticoid usage. Incident cases were confirmed...
Introduction Achieving remission is a critical therapeutic goal in the management of rheumatoid arthritis (RA). Despite methotrexate being cornerstone early RA treatment, significant proportion patients fail to achieve remission. This study aims predict 6-month non-remission 222 disease-modifying anti-rheumatic drug (DMARD)-naïve initiating monotherapy, using baseline patient characteristics from ARCTIC trial. Methods Machine learning models were developed utilizing twenty-one demographic,...
Abstract Purpose Knowledge about factors associated with mortality after hip fracture is important both for analytical and clinical purposes. This study aimed to assess patient risk commonly used composite scores prediction of 1-year in a large cohort. Methods Hip data were prospectively recorded local hospital database. Consecutive fractures from 2006 2020 included, 6040 5496 patients. Associations between different exposures estimated using univariate two multivariate logistic regression...
Rheumatoid arthritis (RA) associated anti-citrullinated protein antibodies (ACPA) target various antigens by binding short citrulline-amino acid motifs, resulting in heterogeneous ACPA-profiles among patients. Here we analyzed ACPA-patterns recognized citrulline-motifs relation to the RA risk factors HLA-DRB1 shared epitope (SE) alleles and history of smoking. factor (RF) anti-cyclic citrullinated peptide (CCP2) isotypes, 15 anti-Cit- four anti-Carb/Acet-peptide-IgG, were centrally measured...
BackgroundAnkle joint arthroplasty is increasingly used in primary or secondary end-stage osteoarthritis. Initial reports on the fourth-generation Infinity total ankle system showed a high failure rate due to component loosening. The objective of this study was assess complications, reoperations, patient reported outcome measures (PROMs) and radiographic findings after 1 year.MethodsData were prospectively collected local surgery registry between January 2018 March 2023. All cases using with...
Objectives Tapering of tumor necrosis factor inhibitor (TNFi) treatment in rheumatoid arthritis (RA) remission is debated. We assessed the effect tapering TNFi to withdrawal versus continued stable on flare‐free survival and joint damage progression over three years. Methods ARCTIC REWIND was a multicenter, open‐label, non‐inferiority trial including patients with RA for ≥12 months therapy. Patients were randomized 1:1 taper or continue treatment. The primary endpoints current study...