A5010042121- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Chronic Lymphocytic Leukemia Research
- Rheumatoid Arthritis Research and Therapies
- Nerve injury and regeneration
- Amyotrophic Lateral Sclerosis Research
- PI3K/AKT/mTOR signaling in cancer
- Neurogenetic and Muscular Disorders Research
- Biosimilars and Bioanalytical Methods
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Dermatology and Skin Diseases
- Epigenetics and DNA Methylation
- Adipose Tissue and Metabolism
- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Autoimmune and Inflammatory Disorders Research
- Receptor Mechanisms and Signaling
- Mitochondrial Function and Pathology
- Erythrocyte Function and Pathophysiology
University of Oslo
2020-2025
Umeå University
2014-2019
Introduction Achieving remission is a critical therapeutic goal in the management of rheumatoid arthritis (RA). Despite methotrexate being cornerstone early RA treatment, significant proportion patients fail to achieve remission. This study aims predict 6-month non-remission 222 disease-modifying anti-rheumatic drug (DMARD)-naïve initiating monotherapy, using baseline patient characteristics from ARCTIC trial. Methods Machine learning models were developed utilizing twenty-one demographic,...
Amyotrophic lateral sclerosis (ALS) is currently an incurable fatal motor neuron syndrome characterized by progressive weakness, muscle wasting and death ensuing 3–5 years after diagnosis. Neurotrophic factors (NTFs) are known to be important in both nervous system development maintenance. However, the attempt translate potential of NTFs into therapeutic options remains limited despite substantial number approaches, which have been tested clinically. Using quantitative RT-PCR (qRT-PCR)...
In humans, there are two forms of glutaminase (GLS), designated GLS1 and GLS2. These enzymes catalyse the conversion glutamine to glutamate. exists as isozymes: kidney (KGA) C (GAC). Several GLS inhibitors have been identified, which DON (6-diazo-5-oxonorleucine), BPTES (bis-2-(5-phenylacetamido-1, 3, 4-thiadiazol-2-yl) ethyl sulphide), 968 (5-(3-Bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one) CB839 (Telaglenastat) most widely used. However,...
Endothelial cell function and metabolism are closely linked to differential use of energy substrate sources combustion. While endothelial migration is promoted by 2‐phosphofructokinase‐6/fructose‐2,6‐bisphosphatase (PFKFB3)‐driven glycolysis, proliferation also depends on fatty acid oxidation for dNTP synthesis. We show that inflammatory activation human umbilical vein cells (HUVECs) interleukin‐1β (IL‐1β), despite inhibiting proliferation, promotes a shift toward more metabolically active...
Delayed-type hypersensitivity arthritis (DTHA) is a recently established experimental model of rheumatoid (RA) in mice with pharmacological values. Despite an indispensable role CD4+ T cells inducing DTHA, potential for cell subsets lacking. Here we have quantified during DTHA development and found that levels activated, pro-inflammatory Th1, Th17, memory draining lymph nodes were increased differential dynamic patterns after induction. Moreover, according to B-cell depletion experiments, it...
To meet the demand for energy and biomass, T lymphocytes (T cells) activated to proliferation clonal expansion, require uptake metabolism of glucose (Gluc) amino acid (AA) glutamine (Gln). Whereas exogenous Gln is converted glutamate (Glu) by glutaminase (GLS), also synthesized from endogenous pool AA through Glu activity synthase (GS). Most this knowledge comes studies on cell cultures under ambient oxygen conditions (normoxia, 21% O2). However, in vivo, antigen induced T-cell activation...
Methotrexate is one of the cornerstones rheumatoid arthritis (RA) therapy. Genetic factors or single nucleotide polymorphisms (SNPs) are responsible for 15%–30% variation in drug response. Identification clinically effective SNP biomarkers predicting methotrexate (MTX) sensitivity has been a challenge. The aim this study was to explore association between disease related outcome MTX treatment and 23 SNPs 8 genes pathway, as well pro-inflammatory gene RA patients naïve MTX. Categorical...
Abstract A majority of lymphomas are derived from B cells and novel treatments required to treat refractory disease. Neurotransmitters such as serotonin dopamine influence activation the effects a selective 1A receptor (5HT1A) antagonist on growth number cell-derived lymphoma cell lines were investigated. We confirmed expression 5HT1A in human tissue several well-defined experimental lines. discovered that pharmacological inhibition led reduced proliferation together with DNA damage,...
Ablation of the immune-specific catalytic subunit Cβ2 protein kinase A is associated with a proinflammatory phenotype and increased sensitivity to autoimmunity in mice. Here we show that tumour growth adenocarcinoma cell line EO771 breast lung after injection into mammary fat pad tail vein, respectively, was significantly reduced mice ablated for compared wild-type In both cases, tumours showed infiltration immune cells lacking Despite this, it appeared solid tissue- versus intravenously...
B lymphocyte development occurs in the bone marrow, while final differentiation and maturation can occur both marrow spleen. Here we provide evidence that signal regulatory protein α (SIRPα), an Ig-superfamily ITIM-receptor expressed by myeloid but not lymphoid cells, is involved regulating cell maturation. Lack of SIRPα signaling adult SIRPα-mutant mice resulted a reduced cells evident numbers semi-mature IgD+IgMhi follicular type-II (F-II) mature IgD+IgMlo type-I (F-I) as well blood...