A5017377295- Prion Diseases and Protein Misfolding
- Crystallization and Solubility Studies
- Immune Cell Function and Interaction
- X-ray Diffraction in Crystallography
- Neurological diseases and metabolism
- Seaweed-derived Bioactive Compounds
- Crystallography and molecular interactions
- Trace Elements in Health
- Antimicrobial Peptides and Activities
- Chemical Synthesis and Analysis
- Biosimilars and Bioanalytical Methods
- Hematopoietic Stem Cell Transplantation
- Reproductive System and Pregnancy
- Immune Response and Inflammation
- Click Chemistry and Applications
- Advanced biosensing and bioanalysis techniques
- Rheumatoid Arthritis Research and Therapies
- S100 Proteins and Annexins
- Chronic Lymphocytic Leukemia Research
- Inflammatory mediators and NSAID effects
- Carbohydrate Chemistry and Synthesis
- T-cell and B-cell Immunology
- RNA Research and Splicing
- Microbial Natural Products and Biosynthesis
- Cancer, Hypoxia, and Metabolism
University of Oslo
2020-2025
Norwegian University of Life Sciences
2017-2020
Aqualine (Norway)
2020
University of Padua
2014-2017
The cellular prion protein PrPC is highly expressed in neurons, but also present non-neuronal tissues, including the testicles and spermatozoa. Most immune cells their bone marrow precursors express PrPC. Clearly, this operates diverse contexts. Investigations into putative stress-protective roles for have resulted an array of functions, such as inhibition apoptosis, stimulation anti-oxidant enzymes, scavenging roles, a role nuclear DNA repair. We studied stress resilience spermatozoa...
Introduction Achieving remission is a critical therapeutic goal in the management of rheumatoid arthritis (RA). Despite methotrexate being cornerstone early RA treatment, significant proportion patients fail to achieve remission. This study aims predict 6-month non-remission 222 disease-modifying anti-rheumatic drug (DMARD)-naïve initiating monotherapy, using baseline patient characteristics from ARCTIC trial. Methods Machine learning models were developed utilizing twenty-one demographic,...
Studies in mice with ablation of Prnp, the gene that encodes cellular prion protein (PrPC), have led to hypothesis PrPC is important for peripheral nerve myelin maintenance. Here, we used a nontransgenic animal model put this idea test; namely, goats that, due naturally occurring nonsense mutation, lack PrPC. Teased fiber preparation revealed demyelinating pathology without Affected nerves were invaded by macrophages and T cells displayed vacuolated fibers, shrunken axons, onion bulbs....
Abstract Prion diseases are progressive and fatal, neurodegenerative disorders described in humans animals. According to the “protein-only” hypothesis, normal host-encoded prion protein (PrP C ) is converted into a pathological infectious form Sc these diseases. Transgenic knockout models have shown that PrP prerequisite for development of disease. In Norwegian dairy goats, mutation (Ter) gene ( PRNP effectively blocks synthesis. We inoculated 12 goats (4 +/+ , 4 +/Ter Ter/Ter...
The cellular prion protein (PrPC) has been extensively studied because of its pivotal role in diseases; however, functions remain incompletely understood. A unique line goats identified that carries a nonsense mutation abolishes synthesis PrPC. In these animals, the PrP-encoding mRNA is rapidly degraded. Goats without PrPC are valuable re-addressing loss-of-function phenotypes observed Prnp knockout mice. As ascribed various roles immune cells, we analyzed transcriptomic responses to loss...
Abstract T cell receptor (TCR)-T based therapies, such as MAGE-A4 TCR-T cells, have shown compelling data demonstrating effective infiltration into and targeting of solid tumors with clinical responses across various cancers. However, heterogeneity down-regulation target antigen HLA expression limit the durability curative potential these types treatments. On other hand, owing to their potency, favorable safety profile applicability “off shelf” therapy, natural killer (NK) cells emerged...
Abstract Peptide‐functionalized gold nanoparticles are supramolecular systems that can mimic natural proteins or DNA. In this work, we describe the preparation, analysis, and biological evaluation of linked to pseudopeptide foldamers containing one eight L ‐Ala‐ D ‐Oxd (Ala = alanine; Oxd 4‐carboxy‐5‐methyloxazolidin‐2‐one) residues. The become increasingly organized as number such moieties increases. Moreover, from analysis chiroptical signals find chirality surface becomes more evident...
Dendritic cells (DCs) regulate the host-microbe balance in gut and skin, tissues likely exposed to nanoparticles (NPs) present drugs, food, cosmetics. We analyzed viability activation of DCs incubated with extracellular media (EMs) obtained from cultures commensal bacteria (Escherichia coli, Staphylococcus epidermidis) or pathogenic (Pseudomonas aeruginosa, aureus) presence amorphous silica (SiO2 NPs). EMs NPs synergistically increased levels cytotoxicity cytokine production, different...
Peptaibiotics are a group of membrane active peptides fungal origin. They typically contain α-aminoisobutyric acid (Aib; 1-letter code, U) and other non-coded residues (Toniolo Brückner, 2009; Neumann et al., 2015; Benedett 1982) [1], [2], [3] stabilizing their helical structure. Peptaibols peptaibiotics carrying 1, 2-aminoalcohol at the C-terminus. When fatty chain (of 8–10 carbon atoms) is present N-terminus, they called lipopeptaibols 2001; Degenkolb 2003) [4], [5]. We found (Tavano 2015)...
Delayed-type hypersensitivity arthritis (DTHA) is a recently established experimental model of rheumatoid (RA) in mice with pharmacological values. Despite an indispensable role CD4+ T cells inducing DTHA, potential for cell subsets lacking. Here we have quantified during DTHA development and found that levels activated, pro-inflammatory Th1, Th17, memory draining lymph nodes were increased differential dynamic patterns after induction. Moreover, according to B-cell depletion experiments, it...
<h3>Background</h3> T cell receptor (TCR)-T based therapies, such as MAGE-A4 targeting TCR-T cells, have shown compelling data demonstrating effective infiltration into solid tumors with clinical responses across various cancers. However, tumour heterogeneity, down-regulation of target antigen and HLA expression limit the durability curative potential these treatments. On other hand, natural killer (NK) their potency, favorable safety profile applicability 'off-the-shelf' therapy enabling...
Abstract Some hybrid foldamers of various length, all containing the (4 R ,5 S )‐4‐carboxy‐5‐methyloxazolidin‐2‐one ( d ‐Oxd) moiety alternating with an l ‐amino acid ‐Val, ‐Lys, or ‐Ala), were prepared in order to study their preferred conformations and evaluate biological activity. Surprisingly, only longer oligomers ‐Ala fold into well‐established helices, whereas other give partially unfolded turn structures. Nevertheless, they show good biocompatibility, no detrimental effects up 64 μ m...