A5044135679- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Bone and Joint Diseases
- Autoimmune and Inflammatory Disorders Research
- Psoriasis: Treatment and Pathogenesis
- Inflammatory Bowel Disease
- Systemic Lupus Erythematosus Research
- Microscopic Colitis
- Spine and Intervertebral Disc Pathology
- Studies on Chitinases and Chitosanases
- Chronic Lymphocytic Leukemia Research
- European and International Law Studies
- Mosquito-borne diseases and control
- Pharmaceutical studies and practices
- Hip disorders and treatments
- Education, Healthcare and Sociology Research
- Autoimmune and Inflammatory Disorders
- Musculoskeletal synovial abnormalities and treatments
- Myofascial pain diagnosis and treatment
- Biosimilars and Bioanalytical Methods
- Viral Infections and Immunology Research
- Musculoskeletal Disorders and Rehabilitation
- Health Systems, Economic Evaluations, Quality of Life
- Dupuytren's Contracture and Treatments
- Parasites and Host Interactions
Glostrup Hospital
2013-2024
Rigshospitalet
2004-2024
Center for Rheumatology
2021
Gentofte Hospital
2008-2020
University of Copenhagen
2007-2013
UNSW Sydney
2013
Diakonhjemmet Hospital
2013
Copenhagen University Hospital
2004-2013
Maastricht University Medical Centre
2013
Capital Region of Denmark
2008-2011
Abstract The aim of the present study was to assess ultrasonography (US) for detection inflammatory and destructive changes in finger toe joints, tendons, entheses patients with psoriasis-associated arthritis (PsA) by comparison magnetic resonance imaging (MRI), projection radiography (x-ray), clinical findings. Fifteen PsA, 5 rheumatoid (RA), healthy control persons were examined means US, contrast-enhanced MRI, x-ray, assessment. Each joint 2nd–5th (metacarpophalangeal proximal...
This article describes a preliminary OMERACT psoriatic arthritis magnetic resonance image scoring system (PsAMRIS) for evaluation of inflammatory and destructive changes in PsA hands, which was developed by the international MRI group. definitions important pathologies peripheral suggestions concerning appropriate sequences use hands are also provided.
To investigate the safety and efficacy of ofatumumab, a novel human anti-CD20 monoclonal antibody (mAb), in patients with active rheumatoid arthritis (RA) whose disease did not respond to > or = 1 disease-modifying antirheumatic drug.This combined phase I/II study investigated 3 doses ofatumumab. In part A (phase I), 39 received 2 intravenous (i.v.) infusions ofatumumab (300 mg, 700 1,000 mg) placebo 4:1 ratio weeks apart, using specified premedication infusion regimen. B II), 225 treatment...
Abstract Objectives Musculoskeletal [MSK] manifestations in patients with inflammatory bowel disease [IBD] are common and associated poorer outcomes. Hence, early detection is important to optimally tailor treatment. We aimed determine the prevalence distribution of lesions peripheral joints entheses newly diagnosed IBD patients. Design Patients from a prospective population-based inception cohort were consecutively included. Data on MSK symptoms collected by questionnaires structured...
Objective. The aim of this multireader exercise was to assess the reliability and sensitivity change psoriatic arthritis magnetic resonance imaging score (PsAMRIS) in PsA patients followed for 1 year. Methods. MRI acquired from 12 with before initiation treatment after months. MR images were scored according PsAMRIS (for synovitis, tenosynovitis, periarticular inflammation, bone marrow edema, erosion, proliferation) under standardized conditions, unknown chronological order....
INTRODUCTION: In patients with inflammatory bowel disease (IBD), co-occurring spondyloarthritis (SpA) leads to poorer outcomes and impaired quality of life, highlighting the importance early detection effective treatment. This is first study assess prevalence distribution axial symptoms magnetic resonance imaging (MRI)-detected involvement spine sacroiliac joints (SIJs) in IBD. METHODS: Newly diagnosed IBD from a prospective, population-based cohort were consecutively recruited....
Objective. In a comparative conventional MRI, dynamic contrast-enhanced (DCE)-MRI, CT and radiography study, the authors aimed to monitor whether inflammation is reduced or even eliminated damage halted in PsA patients receiving anti-TNF therapy.
Abstract Background Plasma YKL‐40 is an inflammatory biomarker. No useful biomarker exists in patients with psoriasis or psoriatic arthritis. Objective To measure and high‐sensitivity C‐reactive protein (hs‐CRP) arthritis before during treatment. Methods In 48 psoriasis, we measured YKL‐40, hs‐CRP Psoriasis Area Severity Index (PASI) at inclusion a subgroup of 14 patients, repeated the measurements after four to six weeks methotrexate 42 arthritis, adalimumab The were divided into responders...
Objective. Magnetic resonance imaging (MRI) is increasingly used to measure articular inflammation and damage in patients with psoriatic arthritis (PsA). We evaluated the reliability of a new OMERACT PsA MRI scoring system, PsAMRIS, fingers. Methods. In 2 separate studies, scans were obtained from clinical evidence synovitis or dactylitis For first cross-sectional study, images at one timepoint. second longitudinal timepoints, 6 weeks apart. Scans scored using PsAMRIS an international...
Introduction Inflammatory bowel diseases (IBD), encompassing Crohn’s disease and ulcerative colitis, are chronic, inflammatory of the gastrointestinal tract. We have initiated a Danish population-based inception cohort study aiming to investigate underlying mechanisms for heterogeneous course IBD, including need for, response to, treatment. Methods analysis IBD Prognosis Study is prospective, unselected, newly diagnosed adult, adolescent paediatric patients with within uptake area Hvidovre...
To investigate the pattern and development of bone erosion proliferation in patients with psoriatic arthritis (PsA) during treatment adalimumab, using high-resolution computed tomography (CT) conventional radiography.Forty-one biologic-naïve PsA were initiated adalimumab 40 mg subcutaneously every other week. CT radiography 2nd-5th metacarpophalangeal (MCP), proximal interphalangeal (PIP), distal (DIP) joints conducted at baseline (n = 41) after 24 weeks 32). Changes are described imaging...
Abstract Objective To investigate the association between clinical joint tenderness and intra- periarticular inflammation as assessed by ultrasound MRI in patients with active PsA to explore if associations differ according patient-reported outcomes (PROs) structural damage. Methods Forty-one hand involvement had 76/78 joints examined for swelling/tenderness of 24 12 finger joints, respectively. Synovitis, tenosynovitis, erosions were using OMERACT definitions scoring systems. Correlation...
The OMERACT magnetic resonance imaging (MRI) in inflammatory arthritis group previously developed the rheumatoid MRI score (RAMRIS) for use clinical studies, evaluated of extremity MRI, and initiated development a psoriatic (PsAMRIS). At 9 looked at clarifications applying RAMRIS, presented data from study examining how contrast agent gadolinium affects RAMRIS outcomes. Much group’s effort has been aimed iterative its PsA score, reported exercises this demonstrated encouraging results,...
<h3>Background</h3> Peripheral musculoskeletal (MSK) symptoms are the most common extra intestinal manifestations (EIMs) in IBD patients, with substantial impact on quality of life. related spondyloarthritis (IBD-SpA) often requires a multidisciplinary evaluation to enable optimal choice treatment and patient care, but systematic rheumatological characterisation this population is scarce [1]. Characterisation IBD-SpA challenged by variety MSK involvement (from arthralgia ankylosing...
<h3>Background</h3> Psoriatic arthritis (PsA) is an inflammatory associated with psoriasis, and The Group for Research Assessment of Psoriasis Arthritis (GRAPPA) has defined clinical core domains assessment PsA. <h3>Objectives</h3> In investigator-initiated trial to evaluate the efficacy adalimumab in patients PsA assessed by Response Criteria (PsARC), American College Rheumatology (ACR) response rates, GRAPPA. <h3>Methods</h3> Anti-TNF-naïve were included a follow-up cohort study, following...
<h3>Background</h3> Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) has been validated in rheumatoid arthritis for measuring inflammation, but rarely studied psoriatic (PsA). <h3>Objectives</h3> To evaluate changes DCE-MRI parameters of inflammation patients with PsA an investigator-initiated trial, during adalimumab therapy. <h3>Methods</h3> Anti-TNF-naïve according to Moll and Wrights criteria, ≥3 swollen joints, tender hand involvement (swelling and/or dactylitis)...