A5081905729- Rheumatoid Arthritis Research and Therapies
- Musculoskeletal synovial abnormalities and treatments
- Systemic Lupus Erythematosus Research
- Spondyloarthritis Studies and Treatments
- Osteoarthritis Treatment and Mechanisms
- Bone and Joint Diseases
- Orthopedic Surgery and Rehabilitation
- Autoimmune and Inflammatory Disorders Research
- Lymphoma Diagnosis and Treatment
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Medical Imaging Techniques and Applications
- Psoriasis: Treatment and Pathogenesis
- Inflammasome and immune disorders
- Lymphadenopathy Diagnosis and Analysis
- Tendon Structure and Treatment
- Orthopaedic implants and arthroplasty
- Advanced MRI Techniques and Applications
- Viral Infections and Immunology Research
- Chronic Lymphocytic Leukemia Research
- Radiomics and Machine Learning in Medical Imaging
- Musculoskeletal Disorders and Rehabilitation
- Systemic Sclerosis and Related Diseases
- Elbow and Forearm Trauma Treatment
- Colorectal Cancer Treatments and Studies
Oslo University Hospital
2021-2025
Diakonhjemmet Hospital
2009-2022
University of Washington
2015
Center for Rheumatology
2013-2015
Leiden University Medical Center
2015
St George Hospital
2015
University of Copenhagen
2013-2014
Metropolitan University College
2014
University College Copenhagen
2014
Glostrup Hospital
2013-2014
The increased information provided by modern imaging has led to its more extensive use. Our aim was develop evidence-based recommendations for the use of in clinical management most common arthropathy, osteoarthritis (OA). A task force (including rheumatologists, radiologists, methodologists, primary care doctors and patients) from nine countries defined 10 questions on role OA support a systematic literature review (SLR). Joints interest were knee, hip, hand foot; modalities included...
To examine the spectrum and severity of magnetic resonance imaging (MRI) findings in patients with early rheumatoid arthritis (RA), to investigate predictive value MRI for subsequent development conventional radiographic (CR) damage erosions.84 consecutive RA disease duration <1 year were enrolled. Patients treated according standard clinical practice, evaluated at baseline, 3, 6 12 months by core measures activity, radiographs both hands wrists dominant wrist. MR images scored OMERACT score...
This article describes a preliminary OMERACT psoriatic arthritis magnetic resonance image scoring system (PsAMRIS) for evaluation of inflammatory and destructive changes in PsA hands, which was developed by the international MRI group. definitions important pathologies peripheral suggestions concerning appropriate sequences use hands are also provided.
Objectives To determine whether MRI and conventional (clinical laboratory) measures of inflammation can predict 3-year radiographic changes measured by the van der Heijde Sharp score in patients with early rheumatoid arthritis (RA). Methods 55 RA disease duration <1 year participated this follow-up study. Patients were evaluated at baseline, 3, 6, 12 36 months swollen tender joint count, activity based on 28-joint erythrocyte sedimentation rate (ESR), C reactive protein, synovitis, bone...
Objective. The Outcome Measures in Rheumatology (OMERACT) Rheumatoid Arthritis (RA) Magnetic Resonance Imaging (MRI) scoring system (RAMRIS), evaluating bone erosion, marrow edema/osteitis, and synovitis, was introduced 2002, is now the standard method of objectively quantifying inflammation damage by MRI RA trials. objective this paper to identify subsequent advances based on them, provide updated recommendations for RAMRIS. Methods. studies relevant RAMRIS technical scientific were...
<h3>Objectives</h3> To explore associations between MRI features and measures of pain physical function in hand osteoarthritis (OA). <h3>Methods</h3> Eighty-five patients (77 women) with mean (SD) age 68.8 (5.6) years underwent contrast-enhanced the interphalangeal joints (dominant hand) clinical joint assessment. One investigator read MRIs for presence/severity osteophytes, space narrowing, erosions, bone attrition, cysts, malalignment, synovitis, flexor tenosynovitis, marrow lesions (BMLs)...
The optimal first-line treatment in early rheumatoid arthritis (RA) is debated. We compared clinical and radiographic outcomes of active conventional therapy with each three biological treatments different modes action.Investigator-initiated, randomised, blinded-assessor study. Patients treatment-naïve RA moderate-severe disease activity were randomised 1:1:1:1 to methotrexate combined (1) therapy: oral prednisolone (tapered quickly, discontinued at week 36) or sulfasalazine,...
In rheumatoid arthritis (RA), radiographic progression may occur despite clinical remission. This be explained by subclinical inflammation. Magnetic resonance imaging (MRI) provides a greater sensitivity than examination and radiography for assessing disease activity. Our objective was to determine the MRI characteristics of RA patients in remission or low activity (LDA) state.Databases from 6 cohorts were collected 5 international centers. according Disease Activity Score28-C-reactive...
To examine the associations between modern imaging modalities and joint damage measured as 1-year MRI erosive progression, in early rheumatoid arthritis (RA) patients.84 RA patients with disease duration of less than 1 year were included this inception cohort. Patients evaluated at baseline, 3, 6 12 months by core measures activity, ultrasound grey-scale (USGS) inflammation, conventional radiography digital x-ray radiogrammetry (DXR) bone mineral density (BMD) cortical hand bone.53 79 (67%)...
Objectives MRI scoring systems for hand osteoarthritis (HOA) are currently not available. The present work proposes the Oslo HOA (OHOA-MRI) score and examines intrareader inter-reader reliability. Methods Relevant features were included in initial version of OHOA-MRI after literature review informal group discussions. After a training session two calibration exercises (with three readers), with low reliability and/or prevalence excluded, feature definitions/gradings improved. In exercise 3...
<h3>Objective</h3> To investigate the reliability of ultrasonographic assessment osteophytes and explore concordance detected by ultrasound, MRI, conventional radiography (CR) clinical joint examination in patients with hand osteoarthritis (HOA). <h3>Methods</h3> The study included 127 HOA (116 women, mean age 68.6 years (SD 5.8)) CR both hands MRI dominant hand. Osteophytes were assessed all imaging modalities on 0–3 scales, whereas bony enlargement was as absent/present. An ultrasound...
<h3>Objectives</h3> To examine whether MRI features predict radiographic progression including erosive evolution in patients from the Oslo hand osteoarthritis (OA) cohort, which is first longitudinal OA study with available MRI. <h3>Methods</h3> We included 74 (91% female, mean (SD) age of 67.9 (5.3) years) dominant and conventional radiographs taken at baseline 5-year follow-up. Baseline MRIs were read according to score. used three definitions progression: Progression joint space narrowing...
Objective. To assess the predictive value of magnetic resonance imaging (MRI)-detected subclinical inflammation for subsequent radiographic progression in a longitudinal study patients with rheumatoid arthritis (RA) clinical remission or low disease activity (LDA), and to determine cutoffs an MRI inflammatory acceptable state RA which rarely occurs. Methods. Patients [28-joint Disease Activity Score-C-reactive protein (DAS28-CRP) < 2.6, n = 185] LDA (2.6 ≤ DAS28-CRP 3.2, 69) data were...
<h3>Objectives:</h3> To evaluate the responsiveness of magnetic resonance imaging (MRI) and ultrasonography (US) compared with conventional measures disease activity structural damage in patients rheumatoid arthritis (RA) during first year treatment anti-tumour necrosis factor α (TNFα). <h3>Methods:</h3> A cohort RA (N = 36, median age 53 years, duration 7.6 years score (DAS28) 5.7) was evaluated by core activity, US (one wrist), MRI wrist) radiography (CR, both hands wrists) at initiation...
A 5-year follow-up study was performed in female RA patients with established disease looking at vertebral fractures, scored on spinal X-rays, and non-vertebral fractures. We found a high incidence rate of fractures these compared to population-based studies.The aim this is investigate the over period cohort postmenopausal rheumatoid arthritis (RA).One hundred fifty were included into OSTRA cohort. The assessed baseline 5 years for incident Spinal X-rays taken using semi-quantitative method...
Objective. The aim of this multireader exercise was to assess the reliability and sensitivity change psoriatic arthritis magnetic resonance imaging score (PsAMRIS) in PsA patients followed for 1 year. Methods. MRI acquired from 12 with before initiation treatment after months. MR images were scored according PsAMRIS (for synovitis, tenosynovitis, periarticular inflammation, bone marrow edema, erosion, proliferation) under standardized conditions, unknown chronological order....
Objective. To develop and validate a magnetic resonance imaging (MRI) method of assessment joint space narrowing (JSN) in rheumatoid arthritis (RA). Methods. Phase A: JSN was scored 0–4 on MR images 5 RA patients 3 controls at 15 wrist sites 2nd–5th metacarpophalangeal (MCP) joints by 8 readers (7 once, one twice), using preliminary scoring system. B: Image review, discussion, consensus definition, revised C: 4 were system (4 results compared with radiographs [Sharp-van der Heijde (SvdH)...
Objectives To examine the construct validity of MRI in detection structural hand osteoarthritis features with conventional radiography (CR) as reference and explore association between radiographic severity MRI-defined pathology. Methods 106 patients (97 women, mean age 68.9 years (SD 5.6)) had 1.0T contrast-enhanced CR dominant hand. The 2nd–5th interphalangeal joints were scored according to preliminary Oslo score Kellgren–Lawrence (KL) scale Osteoarthritis Research Society International...
Objective. To assess changes following treatment and the reliability responsiveness to change of Outcome Measures in Rheumatology (OMERACT) Psoriatic Arthritis Magnetic Resonance Imaging Score (PsAMRIS) a randomized controlled trial. Methods. Forty patients with PsA either placebo or abatacept (ABA) had MRI 1 hand (n = 20) foot at baseline after 6 months. Images were scored blindly twice by 3 independent readers according PsAMRIS (for synovitis, tenosynovitis, periarticular inflammation,...
To develop and test the interreader reliability of OMERACT Hand Osteoarthritis Magnetic Resonance Scoring System (HOAMRIS) for assessment structural inflammatory hand OA features in interphalangeal joints.The HOAMRIS was developed through an iterative process. Selection their scaling agreed upon consensus by members Imaging (MRI) Task Force, using Oslo (OA) MRI Score system as a template. Two exercises were performed, which 6 4 readers participated, respectively. After first exercise, atlas...