A5016602166- Inflammatory Bowel Disease
- Microscopic Colitis
- COVID-19 Clinical Research Studies
- Liver Diseases and Immunity
- Autoimmune and Inflammatory Disorders
- Celiac Disease Research and Management
- COVID-19 and healthcare impacts
- Biosimilars and Bioanalytical Methods
- Diverticular Disease and Complications
- Helicobacter pylori-related gastroenterology studies
- Spondyloarthritis Studies and Treatments
- Diagnosis and treatment of tuberculosis
- Gallbladder and Bile Duct Disorders
- SARS-CoV-2 and COVID-19 Research
- Pharmacological Effects of Natural Compounds
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Screening and Detection
- IL-33, ST2, and ILC Pathways
- Liver Disease Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Adolescent and Pediatric Healthcare
- Pancreatitis Pathology and Treatment
- Rheumatoid Arthritis Research and Therapies
Copenhagen University Hospital
2020-2025
Gentofte Hospital
2023-2025
Hvidovre Hospital
2020-2025
Herlev Hospital
2020-2025
Clinical Trial Investigators
2025
University of Copenhagen
2020-2024
As no population-based study has investigated the susceptibility and disease course of COVID-19 among patients with inflammatory bowel diseases [IBD], we aimed to investigate this topic in a setting.Two cohorts were investigated. First, nationwide cohort all IBD diagnosed was prospectively followed courses both diseases. Second, within 2.6 million Danish citizens, identified individuals tested for SARS-CoV-2 determine occurrence without other immune-mediated [IMIDs].Between January 28, 2020...
ABSTRACT Background The influence of environmental factors on the severity early inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's (CD), is unclear. Herein, we aimed to investigate role in initial phenotype, activity, IBD. Methods Copenhagen IBD Inception Cohort a prospective population‐based cohort patients with newly diagnosed between May 2021 2023. Data were captured at diagnosis using International Organisation (IOIBD) HeartDiet questionnaires. Environmental...
Abstract Objectives Musculoskeletal [MSK] manifestations in patients with inflammatory bowel disease [IBD] are common and associated poorer outcomes. Hence, early detection is important to optimally tailor treatment. We aimed determine the prevalence distribution of lesions peripheral joints entheses newly diagnosed IBD patients. Design Patients from a prospective population-based inception cohort were consecutively included. Data on MSK symptoms collected by questionnaires structured...
Abstract Background and aims Between 5-10% of patients with inflammatory bowel disease (IBD) will eventually be diagnosed primary sclerosing cholangitis (PSC) [1,2]. Studies suggest that a significant number IBD may have PSC despite lacking biochemical or clinical signs, leading to delayed diagnosis. Sometimes, the liver is identified only after severe complications malignancy developed. This highlights need for improved diagnostic markers identify individuals at high risk developing [3]....
Abstract Background Musculoskeletal (MSK) involvement in IBD patients contributes to poorer outcomes and reduced quality of life (QoL). Recognising MSK is important before initiating biologics, as their effects can differ between the gut, peripheral joints spine. We aimed describe prevalence distribution axial symptoms clinical findings starting biological treatment. Methods Bio-naïve were consecutively recruited. assessed using questionnaires a structured interview. A rheumatologist...
Abstract Background Data on the real-world effectiveness and safety of selective JAK inhibitors (JAKis) in ulcerative colitis (UC) Crohn’s disease (CD) are limited. Methods We conducted a multicenter, retrospective study to assess clinical, biochemical, endoscopic outcomes JAKis bio-experienced UC CD patients. Corticosteroid-free clinical remission (CSFCR) was defined as (CR; CDAI<150 CD, partial Mayo score ≤2 with rectal bleeding subscore 0 UC) not receiving local systemic steroids...
Abstract Background Limited comparative data is available on the real-world effectiveness and safety of tofacitinib (TOFA) upadacitinib (UPA) in ulcerative colitis (UC). Methods We conducted an international, multicenter, real-life retrospective cohort study to assess compare short-term TOFA UPA bio-experienced, moderate-to-severe UC. The primary outcome was week 12 corticosteroid-free remission (CSFR) defined as clinical (CR; partial Mayo score [pMayo]<2 with a rectal bleeding...
Abstract Background Abnormal hepatobiliary biochemistry is frequently observed in patients with inflammatory bowel diseases (IBD), encompassing ulcerative colitis (UC) and Crohn’s disease (CD). However, its prevalence clinical implications IBD remain unclear. We aimed to determine the occurrence impact of abnormal newly diagnosed IBD. Methods Between May 1, 2021, April 30, 2023, all adult pediatric incident within a catchment area covering 20% Denmark were enrolled prospective,...
Abstract Background Inflammatory bowel diseases (IBD), encompassing ulcerative colitis (UC) and Crohn’s disease (CD), are associated with increased risk of primary sclerosing cholangitis (PSC). We aimed to determine the occurrence predictors PSC in patients newly diagnosed IBD. Methods Since May 1st, 2021, all adult pediatric incident IBD within a catchment area 20% Denmark were enrolled prospective population-based Copenhagen Inception Cohort.1 All invited for MRCP blood tests (albumin,...
Abstract Background Sex and disease phenotype contribute to heterogeneity in inflammatory bowel diseases (IBD), including ulcerative colitis (UC) Crohn’s (CD). We aimed investigate the relationship between sex, phenotype, patient-reported outcomes (PROs), symptoms newly diagnosed IBD. Methods Between May 1, 2021, April 30, 2023, all adult pediatric patients with incident IBD within a catchment area covering 20% of Denmark were enrolled prospective, population-based Copenhagen Inception...
This study assesses the prognostic role of intestinal ultrasound (IUS) in determining disease course ulcerative colitis (UC) first year after diagnosis. A prospective, multicenter population-based inception-cohort was conducted on patients newly diagnosed with UC. Patients left-sided or extensive UC underwent IUS assessments at diagnosis, three months, and 12 alongside symptomatic, biochemical, endoscopic evaluations. Transmural remission defined as bowel wall thickness ≤ 3 mm without color...
Abstract Background Individuals with Crohn’s disease (CD) and ulcerative colitis (UC) are at risk of developing osteoporosis. In Denmark, osteoporosis has been observed in 12.0% postmenopausal women 2.6% men aged ≥ 50 years the general population. We aimed to conduct a population-based analysis determining bone mineral density (BMD) diagnosis UC CD. Methods All adult patients diagnosed or CD between May 2021 2023 an area covering 20% (1.2 million inhabitants) Danish population were invited...
Musculoskeletal involvement in inflammatory bowel disease (IBD) patients contributes to poorer outcomes and reduced quality of life (QoL). We aimed describe the prevalence distribution peripheral axial musculoskeletal symptoms clinical findings with IBD prior biological treatment. Bio-naïve were consecutively recruited. assessed using questionnaires a structured interview. A rheumatologist conducted evaluation joints entheses, spine mobility, considered various differential diagnoses. Of 82...
Abstract Background and Aims Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with bowel (IBD), comprising Crohn’s (CD) ulcerative colitis (UC). This study aimed to assess the prevalence clinical characteristics of HS in population-based cohort newly diagnosed IBD patients. Methods The Copenhagen Inception Cohort inception patients between May 2021 April 2023. IBD-related data extraintestinal manifestations (EIMs) were collected, identified through validated...
Tofacitinib (TFB) appears to be effective in the treatment of ulcerative colitis (UC); however, available real-world studies are limited by cohort size. TFB could an option acute severe (ASUC). We aimed investigate efficacy and safety moderate-to-severe ASUC. This retrospective, international study enrolling UC patients with ≥6-week follow-up period was conducted from February 1 July 31, 2022. Indications were categorized as ASUC chronic activity (CA). Baseline demographic clinical data...
INTRODUCTION: In patients with inflammatory bowel disease (IBD), co-occurring spondyloarthritis (SpA) leads to poorer outcomes and impaired quality of life, highlighting the importance early detection effective treatment. This is first study assess prevalence distribution axial symptoms magnetic resonance imaging (MRI)-detected involvement spine sacroiliac joints (SIJs) in IBD. METHODS: Newly diagnosed IBD from a prospective, population-based cohort were consecutively recruited....
Abstract Background and Aims Emerging data indicate a stabilizing incidence of inflammatory bowel diseases (IBD), including ulcerative colitis (UC), Crohn’s disease (CD), IBD unclassified (IBDU) in Western countries. We aimed to investigate the IBD, its initial clinical presentation, patient-reported burden. Methods Copenhagen Inception Cohort is prospective, population-based cohort patients with newly diagnosed according ECCO guidelines period between May 2021 2023, within catchment area...