A5101760415- Inflammatory Bowel Disease
- Microscopic Colitis
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Autoimmune and Inflammatory Disorders
- Diverticular Disease and Complications
- Syphilis Diagnosis and Treatment
- Biosimilars and Bioanalytical Methods
- S100 Proteins and Annexins
- Pancreatitis Pathology and Treatment
- Blood disorders and treatments
- Dermatological and Skeletal Disorders
- Nicotinic Acetylcholine Receptors Study
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Viral gastroenteritis research and epidemiology
- Pharmaceutical studies and practices
- Adolescent and Pediatric Healthcare
- Cancer Research and Treatments
- Pregnancy and Medication Impact
- Long-Term Effects of COVID-19
- Abdominal vascular conditions and treatments
- Helicobacter pylori-related gastroenterology studies
Bispebjerg Hospital
1987-2025
Rigshospitalet
2003-2025
University of Copenhagen
1987-2024
Frederiksberg Hospital
2023-2024
Copenhagen University Hospital
2017-2024
Herlev Hospital
2024
Gentofte Hospital
2024
Ringsted Sygehus
2012
As no population-based study has investigated the susceptibility and disease course of COVID-19 among patients with inflammatory bowel diseases [IBD], we aimed to investigate this topic in a setting.Two cohorts were investigated. First, nationwide cohort all IBD diagnosed was prospectively followed courses both diseases. Second, within 2.6 million Danish citizens, identified individuals tested for SARS-CoV-2 determine occurrence without other immune-mediated [IMIDs].Between January 28, 2020...
Abstract Background Despite a growing array of medical treatment options, resection rates for Crohn’s disease (CD) have decreased over time, while re-resection remained stable at approximately one-third in historical cohorts. This study aimed to assess 30-day postoperative outcomes and complication following primary bowel CD patients. Methods encompassed all patients undergoing Eastern Denmark from 2010 2020 (46% the Danish population, n=2,730,000). Clinical characteristics, surgical...
Abstract Background Recent studies suggest that physical activity (PA) may improve the quality of life and relieve fatigue in patients with inflammatory bowel disease (IBD). However, there is no consensus as to what type PA intervention should be offered IBD barriers related stigmatization symptoms calls for an individually tailored approach. We developed a involving patients, health professionals other stakeholders co-creation process. This study aims determine feasibility acceptability...
Abstract Background The pharmacokinetic (PK) profile of vedolizumab during pregnancy is not fully characterised, though concentrations have been reported to drop1.To minimise transplacental transfer, discontinuation in the 3rd trimester has suggested, but this may lead flare IBD and postpartum2. This study aimed characterise changes PK using mathematical modelling explore dosing scenarios guide decisions on 3rd-trimester dosing. Methods A multicenter, prospective, observational was conducted...
Abstract Background Crohn ‘s disease (CD) is characterized by chronic inflammation in the gut, where severe complications such as fibrotic strictures require surgical resection. Stricture development involves excessive extracellular matrix (ECM) deposition due to continuous activation of intestinal myofibroblasts, that further contribute fibrogenesis. Emerging data suggests stricture-related myofibroblasts overexpress a serine protease called fibroblast protein (FAP). Furthermore, type III...
Abstract Background Crohn's disease (CD) is a chronic inflammatory condition that can lead to irreversible intestinal damage. Fibrosis, caused by imbalanced extracellular matrix (ECM) remodeling, difficult manage, as current anti-inflammatory treatments do not prevent or reverse these processes. ECM fragments released during remodeling may serve biomarkers for transmural activity and fibrosis burden. This study evaluated the correlation of serum C3M, PRO-C3, PRO-C16 levels their potential...
Abstract Background Infiltration of neutrophils into the intestinal tissue is a crucial component inflammatory response in Crohn‘s disease (CD). CPa9-HNE, calprotectin fragment released by human neutrophil elastase during NETosis, has been shown to strongly correlate with endoscopic activity bowel (IBD) and serves as an indicator for pharmacodynamic response. Furthermore, emerging data suggests that extracellular traps (NETs) significantly contribute pathogenesis fibrosis. For first time, we...
ABSTRACT Background There is a need to identify peripheral biomarkers reflective of defined disease associated fibroblasts in Ulcerative Colitis (UC), with the aim enabling clinical development approaches for novel‐stromal‐targeted therapeutics individuals at risk fibrostenotic complications. Additionally, longitudinal non‐invasive tissue remodelling, fibroblast biology and pharmacodynamic measurements are needed clinic facilitate stratification. Aim To novel blood protein subsets,...
Abstract To assess the knowledge of health workers on neonatal management, describe care in first 2 h life, and outcomes neonates Tanzania. A prospective cohort study was performed from January to April 2022 at a district hospital Pemba Island, Women admitted active labor, their were eligible for inclusion. Standardized observations after birth, followed by clinical examination, interviews days 7 28 performed. Health given multiple-choice questions management. Immediate skin-to-skin 23%...
Enteroaggregative Escherichia coli (EAEC) is frequently found in diarrheal stools worldwide. It has been associated with persistent diarrhea, weight loss, and failure to thrive children living developing countries. A number of important EAEC virulence genes are identified; however, their roles acute diarrhea have not previously investigated. The aim this study was identify specific duration type Danish children. We aimed improve the current diagnostics enable targeting strains an expected...
The health consequences of coronavirus disease 2019 [COVID-19] among patients with ulcerative colitis [UC] and Crohn's [CD] remain largely unknown. We aimed to investigate the outcomes long-term effects COVID-19 in UC or CD.We conducted a prospective, population-based study covering all Danish CD confirmed between January 28, 2020 April 1, 2021, through medical records questionnaires.All 319 197 who developed Denmark were included this compared background population [N = 230 087]. A...
Abstract Background The rate of having a resection for patients with Crohn's disease (CD) have decreased over decades, while the rates re-resections seem to been stable around 1/3 in historic cohorts. Re-resection might be influenced by targeted therapies. We aimed investigate re-resection and risk recurrence contemporary cohort effect medical treatment on these parameters. Methods This population-based included all CD undergoing primary intestinal between 2010 2020 Eastern Denmark,...
Although impaired regeneration is important in many gastrointestinal diseases including ulcerative colitis (UC), the dynamics of mucosal humans are poorly investigated. We have developed a model to study these processes vivo humans. Epithelial restitution (ER) and extracellular matrix (ECM) regulation after an experimental injury sigmoid colonic mucosa was assessed by repeated high-resolution endoscopic imaging, histological assessment, RNA sequencing, deconvolution analysis, 16S rDNA...
Abstract Background Ulcerative colitis (UC) is characterized by recurrent inflammation and challenging disease monitoring, with invasive endoscopy as the primary diagnostic tool despite inadequacy of standard noninvasive biomarkers. This study evaluates serum extracellular matrix (ECM) fragments, which reflect remodeling mucosa submucosa, potential indicators burden treatment efficacy. We aim to determine whether ECM levels correlate extent severity predict response. Methods conducted a...
Despite advances in the medical treatment of Crohn's disease [CD], many patients will still need bowel resections and face subsequent risk recurrence re-resection. We describe contemporary re-resection rates identify disease-modifying factors for conducted a retrospective, population-based, individual patient-level data cohort study covering 47.4% Danish population, including all CD who underwent primary resection between 2010 2020. Among 631 resected patients, 24.5% second resection, 5.3%...
Abstract Background The chronic inflammation of Ulcerative Colitis (UC) causes excessive extracellular matrix (ECM) remodeling, resulting in clinical complications. Currently, endoscopic evaluation remains the gold standard method for determining disease activity. However, due to its invasiveness and accompanying patient discomfort, novel methods are wanted. Focusing on type III collagen, a major component intestinal ECM, we sought investigate three blood-based neoepitope biomarkers collagen...
Abstract Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) presenting in remitting ulcerations of the colonic mucosa and submucosa. Mucosal healing therefore an important treatment target. While fecal calprotectin common biomarker used to monitor mucosal UC, patient compliance low due preference for serological markers. This study aimed at investigating association serum [CPa9-HNE], non-invasive neo-epitope neutrophil activity, with both clinical endoscopic...
Abstract Background The gold standard for assessing disease activity in ulcerative colitis (UC) is endoscopy, which uncomfortable the patient, and only evaluates superficial layers of colon. Intestinal extracellular matrix (ECM) remodeling highly dynamic during blood spillover ECM components might reflect transmural burden. aim this study was to evaluate baseline serum markers formation (PRO-C11, PRO-C22, PRO-C7) degradation (C7M) assess treatment response UC. Methods Forty-nine UC patients...
Abstract Background Treatment failure with biological agents is common in patients ulcerative colitis (UC), but the impact of baseline histological disease activity unknown. We aimed to investigate predictive role histopathological findings for treatment UC patients. Methods This a sub-study Danish IBD Biobank Project. Adult bio-naïve (n=129) were followed prospectively while undergoing treatment. Histological was assessed using Nancy Index and Geboes score intestinal biopsies sampled before...
Abstract Background Biological treatment failure is common in patients with ulcerative colitis (UC), but the predictive value of baseline histological activity unknown. Aims We aimed to investigate associations between and outcomes after biological UC. Methods Adult biological-naïve UC (n = 150) were followed prospectively during treatment. Histological was assessed using Nancy Index Geboes score. Endoscopic Mayo Subscore (MES). Associations multivariable models. histological, endoscopic,...