A5103065149- Clinical Nutrition and Gastroenterology
- Nutrition and Health in Aging
- Dialysis and Renal Disease Management
- Inflammatory Bowel Disease
- Abdominal Surgery and Complications
- Enhanced Recovery After Surgery
- Central Venous Catheters and Hemodialysis
- Microscopic Colitis
- Diet and metabolism studies
- Gastrointestinal motility and disorders
- Intestinal Malrotation and Obstruction Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Esophageal and GI Pathology
- Diverticular Disease and Complications
- Eosinophilic Esophagitis
- Health Systems, Economic Evaluations, Quality of Life
- Electrolyte and hormonal disorders
- Frailty in Older Adults
- Diabetes Treatment and Management
- Healthcare cost, quality, practices
- Child Nutrition and Feeding Issues
- Intestinal and Peritoneal Adhesions
- Prostate Cancer Treatment and Research
- Diabetes Management and Research
- Acute Kidney Injury Research
Rigshospitalet
2015-2025
Copenhagen University Hospital
2012-2024
University of Copenhagen
2024
Background/Aims: In Denmark, the public healthcare system ensures patients with intestinal failure (IF) same rights for a life‐saving treatment as other organ failures. This study reports epidemiological data from largest Danish IF center. As one of pioneering centers in treating home parenteral nutrition (HPN), this documents HPN evolution and describes demographics outcome world's single‐center cohorts. Methods : We included discharged 1970–2010. Data were extracted according to European...
An impaired hormonal "ileo-colonic brake" may contribute to rapid gastric emptying, hypersecretion, high ostomy losses, and the need for parenteral support in end-jejunostomy short bowel syndrome (SBS) patients with intestinal failure (IF). Liraglutide, a glucagon-like peptide 1 receptor agonist, reduce hypersecretion dampen thereby improving conditions absorption.In an 8-week, open-label pilot study, liraglutide was given subcutaneously once daily 8 patients, aged 63.4 ± 10.9 years (mean...
Abstract Background/Aims : Catheter‐related complications (CRCs) cause mortality and morbidity in patients dependent on parenteral support at home (HPN) due to intestinal failure (IF). This study describes the incidences of CRCs an adult IF cohort over 40 years. It illustrates evolution consequences CRCs, their association demographic characteristics, potential risk factors effort provide rationale for preventive precautions relevant with risk. Methods All discharged HPN from 1970–2010 were...
Abstract Background Despite a growing array of medical treatment options, resection rates for Crohn’s disease (CD) have decreased over time, while re-resection remained stable at approximately one-third in historical cohorts. This study aimed to assess 30-day postoperative outcomes and complication following primary bowel CD patients. Methods encompassed all patients undergoing Eastern Denmark from 2010 2020 (46% the Danish population, n=2,730,000). Clinical characteristics, surgical...
Abstract Background : A common complication in patients receiving home parenteral nutrition (HPN) is catheter‐related bloodstream infections (CRBSIs). The CRBSI incidence has been advocated as an outcome parameter assessing the quality of care. This study aimed to illustrate how use different definitions affects reported incidence. Materials and Methods In observational based on Copenhagen intestinal failure database, all clinically CRBSIs from 2002–2013 were compared with data affiliated...
The objective of this study was to describe a clinically well-defined, single-center, intestinal failure (IF) cohort based on template definitions and classifications endorsed by the European Society for Clinical Nutrition Metabolism (ESPEN).A cross-sectional, retrospective, adult IF cohort, receiving parenteral support (PS), extracted from Copenhagen database at tertiary center, University Hospital, Rigshospitalet, Denmark.Rigshospitalet provided PS 188 patients with December 31, 2011. Six...
Abstract Background The objective of this retrospective cohort study was to assess the frequency, duration, and causes hospitalizations in patients receiving home parenteral support (HPS) due short‐bowel syndrome (SBS) nonmalignant causes. Furthermore, we aimed investigate potential risk factors hypothesized that with shortest remnant, functional, small bowel—hence, highest need for HPS—would have incidence hospitalizations. Methods Patients SBS who initiated HPS period from 1970 2016...
Aim was to investigate the association between quality of life (QoL), bowel anatomy, and need for home parenteral support (HPS) volume in patients with nonmalignant short-bowel syndrome (SBS) intestinal failure (IF).The SBS-QoL scale used a cross-sectional study 95 SBS-IF patients. Sum QoL scores (0: best, 170: worst) were calculated. Patients defined as having small (≤200 cm), jejunostomy or ileostomy subclassified based on functional small-bowel length (cm) into 4 anatomy subgroups: 1a-1d...
Abstract Background The rate of having a resection for patients with Crohn's disease (CD) have decreased over decades, while the rates re-resections seem to been stable around 1/3 in historic cohorts. Re-resection might be influenced by targeted therapies. We aimed investigate re-resection and risk recurrence contemporary cohort effect medical treatment on these parameters. Methods This population-based included all CD undergoing primary intestinal between 2010 2020 Eastern Denmark,...
The natural history of Crohn's disease leading to intestinal failure is not well characterised. This study aims describe the clinical course preceding and compare burden between patients with without failure.
Glucagon-like peptide 2 (GLP-2) is an important regulator of intestinal growth and function. In adherable mixed meals the macronutrient composition with best potential for stimulating GLP-2 secretion not known. We compared effect 3 iso-energetic meals, where approximately 60 % energy ratio was provided as either carbohydrate, fat, or protein, respectively, on post-prandial endogenous secretion. The responses were to profiles YY (PYY), glucose-dependent insulinotropic (GIP). Ten healthy...
Background: A previous study investigated the value of adding a dietitian to geriatric discharge Liaison-Team.The scope this was explore possible economic savings this.Methods: Patients, 70+ and at nutritional risk, were randomized receive Liaison-Team either with (intervention group, IG) or without (control CG).The IG received three home visits by during 12-week period.Data included in analysis time spent dietitian, use oral supplements (ONS) number hospitalization days.Results: Of 71...