A5034250264- Inflammatory Bowel Disease
- Microscopic Colitis
- Biosimilars and Bioanalytical Methods
- Colorectal Cancer Screening and Detection
- Diverticular Disease and Complications
- Eosinophilic Esophagitis
- Gastric Cancer Management and Outcomes
- Liver Diseases and Immunity
- Colorectal Cancer Surgical Treatments
- Anorectal Disease Treatments and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Autoimmune and Inflammatory Disorders
- Celiac Disease Research and Management
- Pharmaceutical studies and practices
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Gut microbiota and health
- Colorectal Cancer Treatments and Studies
- Diagnosis and treatment of tuberculosis
- Esophageal and GI Pathology
- Abdominal Trauma and Injuries
- Systemic Lupus Erythematosus Research
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Tumor Research and Treatment
- Acute Lymphoblastic Leukemia research
University of Szeged
2016-2025
University of Debrecen
2005-2017
Semmelweis University
2017
Hospital de Manises
2016
Hyogo Medical University
2016
Tokyo Medical and Dental University
2015
Complexo Hospitalario Universitario A Coruña
2013
Szent Imre Egyetemi Oktatókórház
2009
Institute of Biochemistry
1968
Background: CT-P13 is the first biosimilar monoclonal antibody to infliximab (IFX); it has been approved for same indications as its IFX counterpart in Hungary. The aim of this study was assess efficacy induction therapy patients with Crohn's disease (CD) and ulcerative colitis (UC).Methods: Patients diagnosed CD UC, who were administered CT-P13, prospectively enrolled. Disease activity estimated at start after therapy. In sigmoideoscopy also performed end therapy.Results: Eighteen 21 UC...
Summary Background Some of the most important questions relating to use biological therapy in inflammatory bowel diseases concern duration maintenance therapy. Aim To assess disease course and frequency relapse Crohn's ( CD ) following discontinuation therapy, determine predictive factors for relapse. Methods One hundred twenty‐one patients who had achieved clinical remission 1 year whom was then discontinued participated this prospective observational study. Eighty‐seven received infliximab...
CT-P13 is the first biosimilar to infliximab that has been approved for same indications as its originator infliximab. No data are available on effect of mucosal healing. The aim this study was evaluate efficacy induction therapy healing in patients with ulcerative colitis [UC]. UC patients, who received from local introduction at three Hungarian and one Czech inflammatory bowel disease centres, were prospectively enrolled. Sigmoidoscopy performed after end week 14. Mucosal defined Mayo...
Perianal fistulas of Crohn's disease (CD) create a significant burden on patients' lives. However, the efficacy and safety adipose-derived mesenchymal stem cell treatment are contradicting, real-world evidence is lacking.
Background. Some of the most important questions relating to use biological therapy in inflammatory bowel diseases concern duration maintenance therapy. The RASH study revealed that previous and dose intensification are associated with restarting Crohn's disease. aim was assess disease course frequency relapse ulcerative colitis (UC) following discontinuation infliximab patients remission determine predictive factors for relapse. Patients methods. Fifty-one UC who had achieved clinical 1...
Background and Aim:Adalimumab [ADA] was approved for the treatment of ulcerative colitis [UC] refractory to conventional therapy in 2012 Europe. Due observed discrepancies between clinical trials practice, data on outcome ADA are really needed from real life. The aim this study estimate short- long-term efficacy safety UC patients each Hungarian biological centre.
Tofacitinib (TFB) appears to be effective in the treatment of ulcerative colitis (UC); however, available real-world studies are limited by cohort size. TFB could an option acute severe (ASUC). We aimed investigate efficacy and safety moderate-to-severe ASUC. This retrospective, international study enrolling UC patients with ≥6-week follow-up period was conducted from February 1 July 31, 2022. Indications were categorized as ASUC chronic activity (CA). Baseline demographic clinical data...
Abstract Background Perianal fistulas of Crohn’s disease (CD) create a significant burden on patient lives. However, the efficacy and safety adipose-derived mesenchymal stem cell treatment are contradicting, real-world evidence is lacking. We aimed to examine usability darvadstrocel therapy in managing perianal CD. Methods In this retrospective multicenter study CD patients with were enrolled followed. The primary outcome was clinical remission (all treated have closed) at weeks 26 52, while...
and anti-IFX antibody (ATI) concentration.We examined the correlation between loss of response, development side effects or hypersensitivity, serum TNF-a, IFX trough levels, ATI concentrations. RESULTS:The TNF-a level was shown to be correlated with presence ATI; positivity significantly low levels IFX.ATIs were detected in 25% IBD patients effects, however no association revealed these lower levels.Previous use ATI, although concomitant immunosuppression did not have any impact on them....
Abstract Background Data on the real-world effectiveness and safety of selective JAK inhibitors (JAKis) in ulcerative colitis (UC) Crohn’s disease (CD) are limited. Methods We conducted a multicenter, retrospective study to assess clinical, biochemical, endoscopic outcomes JAKis bio-experienced UC CD patients. Corticosteroid-free clinical remission (CSFCR) was defined as (CR; CDAI<150 CD, partial Mayo score ≤2 with rectal bleeding subscore 0 UC) not receiving local systemic steroids...
Abstract Background Limited comparative data is available on the real-world effectiveness and safety of tofacitinib (TOFA) upadacitinib (UPA) in ulcerative colitis (UC). Methods We conducted an international, multicenter, real-life retrospective cohort study to assess compare short-term TOFA UPA bio-experienced, moderate-to-severe UC. The primary outcome was week 12 corticosteroid-free remission (CSFR) defined as clinical (CR; partial Mayo score [pMayo]<2 with a rectal bleeding...
Abstract Background Bowel urgency is one of the most bothersome symptoms ulcerative colitis (UC). The Urgency Numerical Rating Scale (U-NRS) measures degree faecal experienced over past 24 hours by patients with UC on a scale 0-10. We assumed that has large variance, as evaluate their own differently. urge may be different quality for two same score. score U-NRS influenced individual’s specific perception (degree pain, speed urge). objective our study was to investigate possible components...
Safety data of the 'real life' use an infliximab biosimilar, CT-P13 in inflammatory bowel disease (IBD) are still lacking. Our aim was to assess frequency and characteristics infusion reactions during therapy 13 Hungarian 1 Czech IBD centres.Clinical safety registered at fixed appointments. Trough levels anti-drug antibody (ADA) concentration were measured by ELISA. Association between demographic, clinical, laboratory parameters reaction rates evaluated statistically.Three hundred...
Background/Aims: Noninvasive activity markers are extremely important in conditions, such as pregnancy, when endoscopy is not recommended.The aim of this prospective study was to determine fecal calprotectin (FC) concentrations healthy non-pregnant and pregnant women patients with inflammatory bowel disease (IBD).Materials Methods: Healthy active inactive IBD were prospectively enrolled study.Demographic clinical parameters scores recorded.Blood stool samples every patient obtained...
The usage of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for the diagnosis solid pancreatic cancer is increasing, however mainly retrospective studies are available about detailed methods sampling. To compare prospectively diagnostic yield EUS-FNA samples obtained with slow-pull (SP) and standard suction technique (SS). sampling was in 72 92 cases (78.3%). Diagnostic 67.4% SS 65.2% SP group. number smear pairs (1.84 vs. 3.56; p < 0.001) blood contamination (1.50 2.19; were...
Gut microbial composition alters in some special situations, such as ulcerative colits (UC) after total proctocolectomy and ileal pouch-anal anastomosis (IPAA) surgery. The aim of our study was to determine the intestinal microbiome UC patients IPAA surgery, compared with patients, familial adenomatous polyposis (FAP) surgery healthy controls. Clinical data blood faecal samples were collected. Faecal microbiota structure determined by sequencing V4 hypervariable region 16S rRNA gene....
Objectives Magnetic resonance imaging (MRI) and transrectal sonography are the two accepted modalities for evaluation of perianal fistulas abscesses. Transperineal is a new technique that easy to learn can be performed at any time. The purpose this study was prospectively compare diagnostic accuracy MRI, sonography, transperineal with surgical findings in patients Crohn disease. Methods All disease underwent within few days before surgery. Fistulas were classified as simple (43.8%) or...
CT-P13, the first biosimilar monoclonal antibody to infliximab (IFX), has been confirmed be efficacious in inducing remission inflammatory bowel diseases (IBD). The aim of this study was evaluate long-term efficacy and safety CT-P13 therapy Crohn's disease (CD) ulcerative colitis (UC), identify predictors sustained clinical response during a 54-week treatment period.Patients with CD UC, who were administered prospectively enrolled. Clinical assessed at week 14 54. Predictive factors for...