A5076276634- Vasculitis and related conditions
- Renal Diseases and Glomerulopathies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Urticaria and Related Conditions
- Inflammasome and immune disorders
- Otitis Media and Relapsing Polychondritis
- Ocular Diseases and Behçet’s Syndrome
- Child and Adolescent Health
- Eosinophilic Esophagitis
- Immunodeficiency and Autoimmune Disorders
- Orthopedic Infections and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Adolescent and Pediatric Healthcare
- Liver Diseases and Immunity
- Systemic Sclerosis and Related Diseases
- Glutathione Transferases and Polymorphisms
- Nephrotoxicity and Medicinal Plants
- Atherosclerosis and Cardiovascular Diseases
- Advanced Glycation End Products research
- Congenital Diaphragmatic Hernia Studies
- Osteomyelitis and Bone Disorders Research
- Genomics and Rare Diseases
- Abdominal Surgery and Complications
- Kawasaki Disease and Coronary Complications
University Hospital Centre Zagreb
2015-2025
University of Zagreb
2014-2025
Center for Rheumatology
2013-2023
Ministry of Health
2022-2023
Croatian Academic and Research Network
2022
University of Osijek
2021
University of Split
2021
University Hospital Dubrava
2021
Klinički bolnički centar Osijek
2021
University of Rijeka
2021
Introduction: Chronic recurrent multifocal osteomyelitis (CRMO) is a rare, skeletal, autoinflammatory disorder that predominantly affects young females. In this case-based review, we present girl with progressive CRMO affecting the spine and causing spinal cord compression required two surgical interventions. Case Report: A 10-year-old was presented to pediatric rheumatologist because of diffuse back pain radiating her legs, waddling gait, sensitivity palpation in caudal cervical vertebral...
Vaskulitis je upalni proces koji zahvaća stijenke krvnih žila kao primarno mjesto upale, što može dovesti do oštećenja tkiva uslijed vaskularne stenoze, okluzije, aneurizme i/ili rupture. Najčešći sistemski vaskulitisi u djece jesu IgA vaskulitis (IgAV) i Kawasakijeva bolest (KB). Gastrointestinalne komplikacije su najčešće akutne IgAV dok zahvaćenost bubrega (nefritis) najvažnija kronična komplikacija. Najvažnije novosti području odnose se na praćenje bolesnika, pri čemu izdvajaju djeca...
Vrućica nepoznatog uzroka relativno je često stanje u pedijatriji koje i dalje predstavlja dijagnostički izazov. O vrućici nepoznata podrijetla ili o nejasnom febrilnom stanju djece govorimo kad vrućica prisutna trajanju duljem od 8 dana dulje, a da pritom anamneza, klinički pregled osnovni laboratorijski nalazi nisu otkrili uzrok vrućice. Infekcije su vodeći vrućice dječjoj dobi, ali slučaju prolongirane osim infekcija treba pomišljati na reumatske, autoimunosne, autoinflamatorne,...
Cilj: Rad donosi pregled novih spoznaja o etiopatogenezi, klasifikaciji i liječenju juvenilnog idiopatskog artritisa (JIA). Metode: Sistematičan recentne literature. Rezultati: JIA je jedna od najčešćih kroničnih bolesti u djece. Nove spoznaje etiologiji patogenezi dovele su do razvoja primjene lijekova – bioloških inhibitora Janus kinaza (JAK), koji iznimno poboljšali očekivane ishode liječenja velikog broja, ali ne svih bolesnika. Kako sada važeća klasifikacija bolesti, koja dijeli na 7...
Studies concerning the genetic background of IgA vasculitis (IgAV), a small-vessel occurring predominantly in childhood, have confirmed that HLA-DRB1 gene showed strong association with disease susceptibility. The objective was to investigate human leukocyte antigen (HLA) polymorphisms among Croatian patients IgAV and their influence on susceptibility clinical heterogeneity. Thus, 130 children 202 unrelated healthy individuals were enrolled study. Genomic DNA extracted from whole peripheral...
Research on spatial variability of the incidence IgA vasculitis (IgAV) in children and its potential implications for elucidation multifactorial aetiology pathogenesis is limited. We intended to observe IgAV vasculitis-associated nephritis (IgAVN) using modern geostatistical methods, hypothesised that their distribution may be spatially clustered.Patients' data were retrospectively collected from 2009 2019 five Croatian University Hospital Centres paediatric rheumatology, census used...
IgA vasculitis (IgAV) is the most common childhood vasculitis. The main cause of morbidity and mortality in children with IgAV nephritis (IgAVN), but risk its development, severity, chronicity remain unclear. Erythrocyte glutathione S-transferase (e-GST) activity has been previously detected as a sensitive marker kidney function impairment several diseases. We spectrophotometrically assessed correlated e-GST between 55 patients without (IgAVwN), 42 IgAVN patients, 52 healthy controls. At...
<b><i>Background/Objective:</i></b> The purpose of this study was to evaluate the prevalence and severity skin involvement in children with IgA vasculitis (IgAV) its relationship clinical biochemical parameters risk developing nephritis (IgAVN), only cause long-term morbidity main prognostic factor IgAV patients. <b><i>Methods:</i></b> This national multicenter retrospective included 611 patients under age 18 years referred five Croatian...
The pathogenesis of IgAV, the most common systemic vasculitis in childhood, appears to be complex and requires further elucidation. We aimed investigate potential role galactose-deficient immunoglobulin A1 (Gd-IgA1), high-mobility group box 1 (HMGB1), receptor for advanced glycation end products (RAGE) protocadherin (PCDH1) IgAV. Our prospective study enrolled 86 patients with IgAV 70 controls. HMGB1, RAGE, Gd-IgA1 PCDH1 serum urine were determined by enzyme-linked immunosorbent assay...
We analysed clinical and biochemical parameters in predicting severe gastrointestinal (GI) manifestations childhood IgA vasculitis (IgAV) the risk of developing renal complications.A national multicentric retrospective study included children with IgAV reviewed five Croatian University Centres for paediatric rheumatology period 2009-2019.Out 611 children, 281 (45.99%) had at least one GI manifestation, while 42 (14.95%) most manifestations. Using logistic regression several factors were...
We explored damage occurrence in patients with childhood-onset SLE (cSLE) and aimed to predict the risk of organ time.The retrospective study included treated for cSLE at Centre Reference Pediatric Adolescent Rheumatology Republic Croatia over a 29-year period.The disease development 97 (77 females) was examined. The median (Q1, Q3) follow-up time 6.5 (2.3, 12.0) years. SDI determined 5 points (6, 12, 24, 36 months, last follow-up). Thirty-eight (48%) had follow-up. Prepubertal group showed...
Abstract Objective Granulomatosis with polyangiitis (GPA) is an ANCA-associated vasculitis. The 2022 ACR/EULAR-endorsed classification criteria for GPA was derived using data only from adult patients. We aimed to assess the performance of ACR/EULAR in paediatric patients and compare it EULAR/Pediatric Rheumatology International Trials Organization (PRINTO)/Pediatric European Society (PReS)-endorsed Ankara 2008 GPA. Methods Retrospective 20 centres 9 countries were evaluated. diagnosis made...
In natural language processing, most problems can be interpreted as text classification tasks, which makes this type of task a central one. A subdivision more complex types made according to whether the is multilabel or multiclass, where both these tackled with either multiclass classifier combination several binary classifiers. An example problem offers way comparing and on same data, results comparable, author MBTI personality type. The dataset used PersonalityCafe MBTI. We focus our...
<h3>Background</h3> Although clinical symptoms and immunological findings are common in both children adults with systemic lupus erythematosus (SLE), generally have a more severe presentation at the time of diagnosis larger number affected organs, much aggressive course greater chance developing organ damage over time. <h3>Objectives</h3> To compare SLEDAI-2K disease activity index patients SLE same adulthood to SLICC/ACR (SDI) cSLE last follow up childhood adulthood. <h3>Methods</h3> This...
The data that support the findings of this study are available upon request from corresponding author, MJ. not publicly due to their containing information could compromise privacy research participants. Appendix S1 Please note: publisher is responsible for content or functionality any supporting supplied by authors. Any queries (other than missing content) should be directed author article.