A5011748714- Inflammasome and immune disorders
- Autoimmune and Inflammatory Disorders Research
- Kawasaki Disease and Coronary Complications
- Nuclear Structure and Function
- interferon and immune responses
- Protein Tyrosine Phosphatases
- Congenital Diaphragmatic Hernia Studies
- Cardiomyopathy and Myosin Studies
- Adolescent and Pediatric Healthcare
- COVID-19 Clinical Research Studies
- Advanced Power Generation Technologies
- Dermatological and COVID-19 studies
- Otitis Media and Relapsing Polychondritis
- Spondyloarthritis Studies and Treatments
- RNA modifications and cancer
- Coal and Coke Industries Research
- Economic and Technological Developments in Russia
- Tracheal and airway disorders
- Congenital heart defects research
- Congenital Anomalies and Fetal Surgery
Medical University of Varna
2019-2023
University of Mining and Geology "Saint Ivan Rilski"
2023
University Hospital St. Marina
2020-2022
To assess current treatment in macrophage activation syndrome (MAS) worldwide and to highlight any areas of major heterogeneity practice.
CANDLE syndrome (an acronym for Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature) is a recently described rare autosomal recessive disorder charaterized by systemic autoinflammation. Clinical manifestations include presentation in the first year of life, episodes fever accompanied erythematous skin lesions, progressive lipodystrophy, violaceous periorbital swelling failure to thrive. This caused loss function mutations malfunction immunoproteasome complex....
We report a clinical case of 4-year-and-10-month-old boy whose first symptoms (fever and tachypnoea) were noticed at the age 6 months. In upcoming months, skin acral violaceous plaques developed. Failure to thrive growth impairment detected. journey find correct diagnosis, lot diseases suspected. The final diagnosis was suggested after more than 2 years since had appeared. A multi-detector computed tomography chest with low radiation dose protocol showed signs interstitial lung disease...
Macrophage activation syndrome is a serious, potentially fatal complication of the systemic form juvenile idiopathic arthritis. It shares some common characteristics with multisystem inflammatory disease in children, which late SARS-CoV-2 infection children. We present an 11-year-old girl diagnosed arthritis who has been macrophage soon after recovering from COVID-19 infection. The patient developed pronounced thrombotic microangiopathy, severe marked by significant drop platelets, anaemia...
Noncompaction cardiomyopathy is a rare cardiomyopathy, which characterized by trabeculations and deep intratrabecular recesses, forming sponge-like appearance of the myocardium. Clinical variability possible – from asymptomatic patients to congestive heart failure, tromboembolic complications, even sudden cardiac death. Two-dimensional echocardiography preferred diagnostic tool, based on specific criteria, are not yet definite. Discovery genetic mutations support diagnosis. The main...
Introduction: Enthesitis-related arthritis (ERA) is a form of juvenile idiopathic (JIA) according to the International League Against Rheumatism (ILAR) classification. accounts for 8.6 18.9% all children with JIA. The first clinical sign ERA usually asymmetrical large joints, especially lower extremities. Axial involvement typically presented by unilateral or bilateral sacroiliitis. Enthesopathy unique feature ERA. Aim: aim this study determine most common characteristics in HLA-B27 positive...
Background Multisystem Inflammatory Syndrome in children related to COVID-19 (MIS-C) is a new condition the aftermath of which yet be studied both Bulgaria and globally. Up mid December 2020, world fatalities are put at 1 582 674, according WHO statistics. Case Presentation Summary We present 15 years old patient with MIS-C, diagnosed acute abdomen, operated andtreated for septic shock syndrome. The current situation represents major clinical challenge part due complex differential diagnosis...