A5100364515- Adipokines, Inflammation, and Metabolic Diseases
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Chemokine receptors and signaling
- Adipose Tissue and Metabolism
- Apelin-related biomedical research
- Anesthesia and Pain Management
- Exercise and Physiological Responses
- Blood Pressure and Hypertension Studies
- Inflammasome and immune disorders
- Cardiovascular Disease and Adiposity
- Computational Drug Discovery Methods
- Cardiac, Anesthesia and Surgical Outcomes
- Diabetes Treatment and Management
- SARS-CoV-2 detection and testing
- Viral Infections and Vectors
- IL-33, ST2, and ILC Pathways
- Nursing Diagnosis and Documentation
- vaccines and immunoinformatics approaches
- Liver Diseases and Immunity
- Traumatic Brain Injury and Neurovascular Disturbances
- Lipid metabolism and disorders
- Biomarkers in Disease Mechanisms
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Peking Union Medical College Hospital
2025
Peking University
2001-2023
Peking University People's Hospital
2023
National Clinical Research Center for Digestive Diseases
2023
Hefei University of Technology
2021-2022
Central South University
2021
InferVision (China)
2021
Second Xiangya Hospital of Central South University
2021
Peking University International Hospital
2021
Although markers of systemic inflammation may have a role in the development hypertension, supportive clinical data remain limited. We, therefore, examined interleukin (IL)-6 and C-reactive protein (CRP) nested case-control study 400 women developing hypertension an equal number age-matched normotensive control subjects during 10 years follow-up as part Women’s Health Study. All initially had nonhypertensive blood pressure values no history diagnosis or treatment. Subjects provided...
Cytokines are small proteins that have an essential role in the immune and inflammatory responses. The repertoire of cytokines is becoming diverse expanding. Here we report identification characterization a novel cytokine designated as chemokine-like factor 1 (CKLF1). full-length cDNA CKLF1 530bp long single open reading frame encoding 99 amino acid residues. bears no significant similarity to any other known its sequence. Expression can be partly inhibited by interleukin 10 PHA-stimulated...
Cytokines are small proteins that have an essential role in the immune and inflammatory responses. The repertoire of cytokines is becoming diverse expanding. Here we report identification characterization a novel cytokine designated as chemokine-like factor 1 (CKLF1). full-length cDNA CKLF1 530bp long single open reading frame encoding 99 amino acid residues. bears no significant similarity to any other known its sequence. Expression can be partly inhibited by interleukin 10 PHA-stimulated...
Hepatocyte proliferation could result in the loss of covalently closed circular DNA (cccDNA) and emergence cccDNA-cleared nascent hepatocytes, which appear refractory to hepatitis B virus (HBV) reinfection with unknown mechanism(s). Sodium taurocholate cotransporting polypeptide (NTCP) is functional receptor for HBV entry. In this study, down-regulation cell membrane localized NTCP expression proliferating hepatocytes was found prevent infection HepG2-NTCP-tet cells liver-humanized mice....
Background Several cross‐sectional, but few prospective, studies suggest that inflammation may be involved in the development of hypertension. We examined markers inflammation—high‐sensitivity C‐reactive protein, interleukin‐6, and soluble intercellular adhesion molecule‐1—and a marker fibrinolysis, D‐dimer, for their associations with incident hypertension Physicians' Health Study. Methods Results Baseline blood values information on hypertension‐related risk factors were collected 1982....
Minimally invasive direct coronary artery bypass (MIDCAB) surgery is associated with significant postoperative pain. We aimed to investigate the efficacy of ultrasound-guided erector spinae plane block (ESPB) for analgesia after MIDCAB. conducted randomized controlled trial in 60 patients undergoing MIDCAB who received either a single-shot ESPB 30 mL ropivacaine 0.5% (ESPB group, n = 30) or normal saline 0.9% (control 30). The primary outcome was numerical rating scale (NRS) pain scores at...
We report the first identification of Zika virus in Pakistan following genomic and serological analyses blood samples from 20 patients with febrile illness. In November 2021, an outbreak dengue-like illness occurred metropolitan city Karachi. Viral genome capture sequencing seven revealed six cases dengue serotype 2 two infections, including one co-infection. The next year, severe flooding, 13 suspected were screened by real time qRT-PCR serology, 92% (12/13) had evidence current or recent...
Background Acute phase proteins highlight the dynamic interaction between inflammation and oncogenesis. GlycA, a novel nuclear magnetic resonance (NMR) inflammatory marker that identifies primarily circulating N-acetyl glycan groups attached to acute proteins, may be future CRC risk biomarker. Methods We examined association GlycA incident mortality in two prospective cohorts (N = 34,320); Discovery cohort: 27,495 participants from Women's Health Study (WHS); Replication 6,784 Multi-Ethnic...
BACKGROUND Systemic inflammation and endothelial activation are implicated in the development of hypertension. However, epidemiologic studies have yet to compare multiple corresponding biomarkers relation risk hypertension, particularly multiethnic populations. METHODS We identified 800 individuals with incident hypertension matched controls, each group equal numbers white black women, a nested case-control study within Women's Health Initiative Observational Study. measured markers...
Despite the availability of antibiotics, current therapies to treat sepsis are still ineffective and many clinical trials aimed at neutralizing specific inflammatory cytokines have failed, suggesting urgent need for new treatments. Using two models LPS-induced endotoxemia cecal ligation puncture (CLP)-induced sepsis, we investigated effects C1q/TNF-related protein 4(CTRP4) on septic lethality sepsis-induced inflammation. The CTRP4 survival, inflammation, organ damage, bacterial clearance...
The level of total adiponectin, a mixture different adiponectin forms, has been reported associated with breast cancer risk inconsistent results. Whether the forms play roles in prediction is unclear. To examine this, we measured and high molecular weight (HMW) case-control study (1167 sets). Higher circulating HMW was negatively after adjusting for menopausal status family history (P=0.024). We analyzed relationship between 6 subgroups. also (P=0.020, 0.014, 0.035) subgroups postmenopausal...
Angelicae Sinensis Radix is commonly used in traditional Chinese medicine. Pharmacological studies show that has clear anticoagulant activity. Therefore, this study, the activity of crude extracts was investigated by measuring thrombin times extracts. The results revealed petroleum ether-soluble fraction exhibited significant <i>in vitro</i>, and 26 compounds were characterized high-performance liquid chromatography with diode array detection combined electrospray ionization ion trap...
Adiponectin may have a protective role in the development of obesity-related metabolic and vascular disorders, including hypertension. We conducted prospective, nested case control study to investigate relation between baseline plasma adiponectin, measures adiposity, subsequent risk hypertension.We selected 400 white black postmenopausal women, age <70 years, who developed incident hypertension during 5.9-year follow-up an equal number age- race-matched controls Women's Health Initiative...
Both nonalcoholic fatty liver disease (NAFLD) and chronic hepatitis B infection (CBI) are the most prevalent diseases 25-30% of CBI patients estimated to have co-existing NAFLD, interaction between hepatic steatosis HBV their contribution course is an emerging interest. This study explored association NAFLD effect on response antiviral therapy in pediatric population. All children aged 0-18 years with biopsy-proven or were consecutively collected from January 2010 March 2018 a tertiary...