A5006897612- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Health Sciences Research and Education
- Reproductive System and Pregnancy
- Malaria Research and Control
- Immunotherapy and Immune Responses
- Primary Care and Health Outcomes
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Complement system in diseases
- Hematopoietic Stem Cell Transplantation
- Sleep and related disorders
- Animal Virus Infections Studies
- Acute Myeloid Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Interprofessional Education and Collaboration
- Healthcare Systems and Technology
- Mosquito-borne diseases and control
- Cancer survivorship and care
- Nursing Roles and Practices
- Mast cells and histamine
- Childhood Cancer Survivors' Quality of Life
- Palliative Care and End-of-Life Issues
- CAR-T cell therapy research
- Cytomegalovirus and herpesvirus research
National Institute of Allergy and Infectious Diseases
2013-2024
National Institutes of Health
2008-2024
Frederick National Laboratory for Cancer Research
2024
Government of the United States of America
2023
Washington State University Spokane
2021-2022
Georgia Highlands College
2022
Georgetown University
2022
Scripps Research Institute
2021
The University of Texas at Austin
2020
St David's Medical Center
2016-2017
The potential for future coronavirus outbreaks highlights the need to broadly target this group of pathogens. We used an epitope-agnostic approach identify six monoclonal antibodies that bind spike proteins from all seven human-infecting coronaviruses. All conserved fusion peptide region adjacent S2' cleavage site. COV44-62 and COV44-79 neutralize alpha- betacoronaviruses, including severe acute respiratory syndrome 2 (SARS-CoV-2) Omicron subvariants BA.2 BA.4/5, albeit with lower potency...
Bispecific antibodies targeting multiple regions of the SARS-CoV-2 spike protein comparably neutralize variants concern and wild-type virus.
CIS43LS is a monoclonal antibody that was shown to protect against controlled Plasmodium falciparum infection in phase 1 clinical trial. Whether can prevent P. region which the endemic unknown.We conducted 2 trial assess safety and efficacy of single intravenous infusion healthy adults Mali over 6-month malaria season. In Part A, assessed at three escalating dose levels. B, participants were randomly assigned (in 1:1:1 ratio) receive 10 mg per kilogram body weight, 40 kilogram, or placebo....
BackgroundSubcutaneous administration of the monoclonal antibody L9LS protected adults against controlled Plasmodium falciparum infection in a phase 1 trial. Whether administered subcutaneously can protect children from P. region where this organism is endemic unclear.MethodsWe conducted 2 trial Mali to assess safety and efficacy subcutaneous 6 10 years age over 6-month malaria season. In part A trial, was assessed at three dose levels adults, followed by assessment two children. B were...
Humanity has faced three recent outbreaks of novel betacoronaviruses, emphasizing the need to develop approaches that broadly target coronaviruses. Here, we identify 55 monoclonal antibodies from COVID-19 convalescent donors bind diverse betacoronavirus spike proteins. Most targeted an S2 epitope included K814 residue and were non-neutralizing. However, 11 targeting stem helix neutralized betacoronaviruses different lineages. Eight in this group, including six broadest most potent...
IgG antibodies play a role in malaria immunity, but whether and how IgM protects from the biology of Plasmodium falciparum (Pf)–specific B cells is unclear. In Mali cohort spanning infants to adults, we conducted longitudinal analyses Pf- influenza-specific cells. We found that Pf-specific memory (MBCs) are disproportionally IgM+ only gradually shift IgG+ with age, contrast MBCs predominantly infancy adulthood. cell receptor analysis showed somatically hypermutated at levels comparable...
Several infectious and autoimmune diseases are associated with an expansion of CD21 − CD27 atypical B cells (atBCs) that up-regulate inhibitory receptors exhibit altered cell receptor (BCR) signaling. The function atBCs remains unclear, few studies have investigated the biology pathogen-specific during acute infection. Here, we performed longitudinal flow cytometry analyses RNA sequencing Plasmodium falciparum ( Pf )–specific isolated from study participants before shortly after febrile...
Binding of NK cell inhibitory receptors to MHC class I (MHC-I) confers increased responsiveness cells by a process known as licensing/education. Reduced MHC-I expression or lack for results in diminished responsiveness. In this study, we evaluated the effect human and mouse licensing on early stages natural cytotoxicity. Unlicensed did not form many stable conjugates with target cells. The reduction conjugation was attributed altered β2 integrin LFA-1 properties but instead due reduced...
Australia experiences a high incidence of natural emergencies and Australian governments have committed significant investment into emergency preparedness response. Amongst the population groups most vulnerable to are infants young children with their vulnerability centering around specific food fluid needs. For this reason, World Health Assembly has urged all member states develop implement infant child feeding in (IYCF-E) plans line international guidance. This study aimed determine degree...
Interleukin 15 (IL-15) is an essential cytokine for the survival and proliferation of natural killer (NK) cells. IL-15 activates signaling by β common γ (γc) chain heterodimer IL-2 receptor through trans-presentation cells expressing bound to α (IL-15Rα). We show here that membrane-associated IL-15Rα-IL-15 complexes are transferred from presenting NK trans-endocytosis contribute phosphorylation ribosomal protein S6 cell proliferation. interaction with soluble or surface-bound complex...
A functional human IgA response to malaria targets a conserved epitope in the N terminus of Plasmodium falciparum circumsporozoite protein.
<sec> <title>BACKGROUND</title> Current longitudinal insomnia assessments are subjective. Accurate assessment requires objective, longitudinal, naturalistic measures. Objective, ecologically-valid, sleep measurements needed to help identify and manage at a clinical population level. A potential solution is consumer technologies which growing in popularity but rarely used clinically. </sec> <title>OBJECTIVE</title> We sought prove the utility of contactless, radiofrequency-based device by...
Background. Human natural killer (NK) cell activity is regulated by a family of killer-cell Ig-like receptors (KIR) that bind human leucocyte antigen (HLA) class I. Combinations KIR and HLA genotypes are associated with disease, including susceptibility to viral infection disorders pregnancy. KIR2DL1 binds HLA-C alleles group C2 (Lys80). KIR2DL2 KIR2DL3 C1 (Asn80). However, this model cannot explain allelic effects in disease or the impact HLA-bound peptides. The goal study was determine...
Ebola virus infection causes a highly lethal hemorrhagic fever syndrome associated with profound immunosuppression through its ability to induce widespread inflammation and cellular damage. Though GP, the viral envelope glycoprotein, mediates many of these effects, molecular events that underlie cytopathicity are poorly understood. Here, we define mechanism responsible for GP cytotoxicity. selectively decreased expression cell surface molecules essential adhesion immune function....