Cherrelle Dacon
A5041207901- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- HIV Research and Treatment
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Complement system in diseases
- Antifungal resistance and susceptibility
- Nail Diseases and Treatments
- T-cell and B-cell Immunology
- Fungal Infections and Studies
- HIV/AIDS Research and Interventions
- Bacterial biofilms and quorum sensing
- Immune cells in cancer
- Bacteriophages and microbial interactions
- Malaria Research and Control
- Mosquito-borne diseases and control
- Antimicrobial Resistance in Staphylococcus
- Ear Surgery and Otitis Media
- HIV-related health complications and treatments
National Institute of Allergy and Infectious Diseases
2021-2025
National Institutes of Health
2021-2025
University of Oxford
2017-2018
University of the West Indies
2015
The potential for future coronavirus outbreaks highlights the need to broadly target this group of pathogens. We used an epitope-agnostic approach identify six monoclonal antibodies that bind spike proteins from all seven human-infecting coronaviruses. All conserved fusion peptide region adjacent S2' cleavage site. COV44-62 and COV44-79 neutralize alpha- betacoronaviruses, including severe acute respiratory syndrome 2 (SARS-CoV-2) Omicron subvariants BA.2 BA.4/5, albeit with lower potency...
Bispecific antibodies targeting multiple regions of the SARS-CoV-2 spike protein comparably neutralize variants concern and wild-type virus.
The most advanced monoclonal antibodies (mAbs) and vaccines against malaria target the central repeat region or closely related sequences within Plasmodium falciparum circumsporozoite protein (PfCSP). Here, using an antigen-agnostic strategy to investigate human antibody responses whole sporozoites, we identified a class of mAbs that cryptic PfCSP epitope is only exposed after cleavage subsequent pyroglutamylation (pGlu) newly formed N terminus. This pGlu-CSP not targeted by current...
Humanity has faced three recent outbreaks of novel betacoronaviruses, emphasizing the need to develop approaches that broadly target coronaviruses. Here, we identify 55 monoclonal antibodies from COVID-19 convalescent donors bind diverse betacoronavirus spike proteins. Most targeted an S2 epitope included K814 residue and were non-neutralizing. However, 11 targeting stem helix neutralized betacoronaviruses different lineages. Eight in this group, including six broadest most potent...
Otitis externa is a common inflammatory ear disease in dogs caused by variety of pathogens, and coagulase-positive staphylococci are frequently isolated from such infections.To identify antimicrobial susceptibility profiles methicillin-resistant strains among otitis dogs.A cross-sectional study was performed over 2 years on 114 client-owned presented to the Veterinary Teaching Hospital with primary complaint infections. Swabs were obtained both ears cultured for which subsequently confirmed...
The potential for future coronavirus outbreaks highlights the need to develop strategies and tools broadly target this group of pathogens. Here, using an epitope-agnostic approach, we identified six monoclonal antibodies that bound spike proteins from all seven human-infecting coronaviruses. Epitope mapping revealed conserved fusion peptide region adjacent S2' cleavage site. Two antibodies, COV44-62 COV44-79, neutralize a range alpha beta coronaviruses, including SARS-CoV-2 Omicron...
Cryptococcosis causes approximately 180 000 deaths each year in patients with human immunodeficiency virus (HIV). Patients other forms of immunosuppression are also at risk, and disease is increasingly recognized apparently immunocompetent individuals. Cryptococcus neoformans var. grubii, responsible for the majority cases, distributed globally. We used consensus ISHAM Multilocus sequence typing (MLST) scheme to define population structure clinical C. grubii isolates from Laos (n = 81),...
Abstract The emergence of SARS-CoV-2 variants that threaten the efficacy existing vaccines and therapeutic antibodies underscores urgent need for new antibody-based tools potently neutralize by targeting multiple sites spike protein. We isolated 216 monoclonal from plasmablasts memory B cells COVID-19 patients. three most potent targeted distinct regions RBD, all neutralized B.1.1.7 B.1.351. crystal structure antibody, CV503, revealed it binds to ridge region competes with ACE2 receptor, has...
HIV-specific CD8+ T cells play a central role in immune control of adult HIV, but their contribution pediatric infection is less well characterized. Previously, we identified group ART-naive children with persistently undetectable plasma viremia, termed "elite controllers," and second who achieved aviremia only transiently. To investigate the mechanisms failure to maintain aviremia, characterized three transient aviremic individuals (TAs), each whom expressed disease-protective HLA-B*81:01,...
Abstract Cryptococcosis is amongst the most important invasive fungal infections globally, with cryptococcal meningitis causing an estimated 180,000 deaths each year in HIV infected patients alone. Patients other forms of immunosuppression are also at risk, and disease increasingly recognized apparently immunocompetent individuals. Cryptococcus neoformans var. grubii (serotype A, molecular type VNI) has a global distribution responsible for majority cases. Here, we used consensus ISHAM...
Summary Long-lived plasma cells (PCs) secrete antibodies that can provide sustained immunity against infection. It has been proposed high affinity are preferentially selected into this compartment, potentiating the immune response. Here we used single cell RNA-seq to track development of Igh g2A10 cells, specific for Plasmodium falciparum circumsporozoite protein ( Pf CSP) within germinal center (GC). We identified differentiating memory B (MBC) or PCs and estimated their by V(D)J...