A5002188913- Malaria Research and Control
- Trypanosoma species research and implications
- Complement system in diseases
- Analytical Chemistry and Chromatography
- Synthesis and Catalytic Reactions
- Drug Transport and Resistance Mechanisms
- HIV Research and Treatment
- Drug Solubulity and Delivery Systems
- Antibiotics Pharmacokinetics and Efficacy
- Mosquito-borne diseases and control
Walter Reed Army Institute of Research
2019-2021
A functional human IgA response to malaria targets a conserved epitope in the N terminus of Plasmodium falciparum circumsporozoite protein.
The discovery of new targets for the treatment malaria, in particular those aimed at pre-erythrocytic stage life cycle, advanced with demonstration that orally administered inhibitors Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) could clear infection a murine model. This enthusiasm was tempered by unsatisfactory safety and/or pharmacokinetic issues found these chemotypes. To address urgent need scaffolds, this paper presents initial structure–activity relationships an...
Abstract Particle size is an important determinant of gastrointestinal absorption compounds administrated orally. The present study evaluates the effect a reduction in particle assessed by homogenization, sonication, and homogenization plus sonication on bioavailability imidazolidinedione (IZ), antimalarial compound with known causal prophylactic activity radical cure relapsing malaria. Formulations were intragastrically to mice, blood samples collected for LC-MS/MS analysis. method manually...
ABSTRACT The discovery of new targets for treatment malaria advanced with the demonstration that orally administered inhibitors Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) could clear infection in a murine model. This enthusiasm was tempered by unsatisfactory safety and/or pharmacokinetic issues found these chemotypes. To address urgent need scaffolds, we recently reported and optimization novel, potent isoxazole-based PfPKG lacked any obvious warnings. manuscript presents...
ABSTRACT The discovery of new targets for treatment malaria and in particular those aimed at the pre-erythrocytic stage life cycle, advanced with demonstration that orally administered inhibitors Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) could clear infection a murine model. This enthusiasm was tempered by unsatisfactory safety and/or pharmacokinetic issues found these chemotypes. To address urgent need scaffolds, this manuscript presents initial structure-activity...