A5045907717- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Inflammatory Bowel Disease
- Diverticular Disease and Complications
- Mycobacterium research and diagnosis
- Plant-based Medicinal Research
- Genomics, phytochemicals, and oxidative stress
- Helicobacter pylori-related gastroenterology studies
- Multiple and Secondary Primary Cancers
- Adipose Tissue and Metabolism
- Colorectal Cancer Treatments and Studies
- Liver Diseases and Immunity
- Cancer Genomics and Diagnostics
- Plant chemical constituents analysis
- Gut microbiota and health
- Alkaloids: synthesis and pharmacology
- Microbial Natural Products and Biosynthesis
- Esophageal Cancer Research and Treatment
- Ginseng Biological Effects and Applications
- Fatty Acid Research and Health
- Microscopic Colitis
Tianjin University of Traditional Chinese Medicine
2022-2024
Tianjin People's Hospital
2022-2024
Nankai University
2024
Abstract Aim Both the clinical manifestation and molecular characteristics of colorectal cancer (CRC) vary according to anatomical site. We explored risk factors for four groups neoplasms (CRN) at different sites. Methods extracted data from database Tianjin Colorectal Cancer Screening Program 2010 2020. According CRN sites, patients were divided into groups: proximal colon group, distal rectum multiple Binary logistic regression analysis was used explore differences in Results The numbers...
Recent studies have shown that deficient mismatch repair (dMMR) rectal cancer may be related to treatment resistance, resulting in a worse prognosis than proficient MMR (pMMR) cancer. The purpose of this study was explore whether surgery plus other treatments (radiotherapy and chemotherapy) can bring more benefits these patients alone.A retrospective 168 with adenocarcinoma who underwent total mesorectal excision conducted using immunohistochemical methods determine status propensity score...
Abstract Objective Existing studies indicate that advanced colorectal neoplasms exhibit distinct clinical and biological traits based on anatomical sites. However, in China, especially for neoplasms, there's limited information available these traits. Our primary objective is to comprehensively study the characteristics of neoplasm patients different sites China. Methods We selected from cancer screening database Tianjin, since 2010 as subject. chose valid 3113 with comprehensive data...
Methylated syndecan2 (mSDC2) in stool samples has been found to be associated with colorectal cancer (CRC) and precancerous lesions. However, the available data are limited, no previous studies have compared analysis of mSDC2 other diagnostic tests. Thus, we aimed evaluate clinical performance a test compare its that blood-based tests for methylated septin9 (mSEPT9), carcinoembryonic antigen (CEA), carbohydrate 19-9 (CA19-9) 724 (CA724) detecting neoplasms.The gold standard technique was...
Purpose: To explore whether machine learning models using serological markers can predict the relapse of Ulcerative colitis (UC). Patients and Methods: This clinical cohort study included 292 UC patients, were obtained when patients discharged from hospital. Subsequently, four including random forest (RF) model, logistic regression decision tree, neural network compared to UC. A nomogram was constructed, performance these evaluated by accuracy, sensitivity, specificity, area under receiver...
Abstract Objectives While the delay in adjuvant chemotherapy (AC) is known to impact colon cancer outcomes, its effect on rectal less clear. This study aims evaluate influence of AC timing survival stage II and III cancer. Methods retrospective multicenter enrolled 1,144 patients receiving following resection II–III cancers. The delayed was assessed using multivariable Cox models with restricted cubic splines logistic regression. Results Compared initiating within four weeks postsurgery,...
Introduction Dietary advanced lipoxidation end products (ALEs), which are abundant in heat-processed foods, could induce lipid metabolism disorders. However, limited studies have examined the relationship between maternal ALEs diet and offspring health. Methods To investigate transgenerational effects of ALEs, a cross-generation mouse model was developed. The C57BL/6J mice were fed with dietary during preconception, pregnancy lactation. Then, changes glycolipid gut microbiota analyzed....
Background: Zanthoxylum bungeanum seed oil (ZBSO) is extracted from the seeds of traditional Chinese medicine Z. Maxim, which has been shown to have anti-melanoma effects. However, specific mechanisms are not illustrated adequately. Aims: To further investigate mechanism by ZBSO inhibits melanoma and provide scientific evidence support as a potential therapeutic candidate. Methods: CCK-8 assays were used detect function on A375 cells. Based transcriptomics analyses, Western blot analysis was...
Colorectal cancer (CRC) is one of the most common cancers and associated with high incidence mortality rates worldwide. CRC has caused a tremendous loss human health wealth. The colorectal carcinoma are increasing in young adults. Early detection prevention made possible through screening. At present, faecal immunochemical test (FIT) noninvasive method that can be used for large-scale clinical screening status. Therefore, this study, based on results Tianjin from 2012 to 2020, was conducted...
BACKGROUND We aimed to evaluate the ability of circulating cell-free methylated SETP9 DNA (mSEPT9) identify recurrence and determine its clinical utility in adjuvant chemotherapy (ACT) regimen decisions. MATERIAL AND METHODS This study enrolled 426 patients with stage II-III CRC who received radical resection between January 8, 2018, November 30, 2020. The median follow-up duration was 15.8 months (range, 8.1-43.4 months). primary endpoint recurrence-free survival (RFS). A propensity score...
Abstract Objectives With the intention of providing a reference for secondary prevention, our study provides some insight on diagnostic yield factors influencing compliance with colonoscopy and presence advanced adenomas (AA). Methods We conducted large-scale CRC screening among local Tianjin residents aged 40–75 years between 2012 2019. A high-risk factor questionnaire (HRFQ) was distributed to each participant, followed by performance fecal immunochemical test (FIT). Participants who...
Objectives:We investigated the impact of high-risk factors in stage II (TNM stage) rectal cancer patients to determine whether they benefit from adjuvant chemotherapy after surgery.Additionally, we explored interaction between and chemotherapy.Our study provides refined guidance for postoperative treatment with cancer.Methods: The retrospective included 570 adenocarcinoma who underwent total mesorectal excision surgery at Tianjin Union Medical Center August 2012 July 2019.We employed Cox...
Abstract This retrospective cohort study aimed to identify baseline patient characteristics involving modifiable lifestyle factors that are associated with the development of colorectal adenomas, and establish validate a nomogram for risk predictions among high-risk populations negative index colonoscopy. A total 83,076 participants who underwent an colonoscopy at Tianjin Union Medical Center between 2004 2019 were collected. According meticulous inclusion exclusion criteria, 249 subjects...
Background: Prior studies have affirmed the safety and effectiveness of traditional Chinese medicine in treating colorectal cancer patients. However, definitive evidence regarding whether can significantly enhance survival patients remains elusive. This study seeks to provide conclusive insights by examining postoperative administration Xihuang capsules, Pingxiao Zilongjin tablets its impact on 5-year overall (OS) disease-free (DFS) rates among Methods: A retrospective was conducted,...
We evaluate the prognostic value of chemotherapy and other factors on overall survival among colon patients with deficient mismatch repair (dMMR), determine optimum time to start after surgery. Data 306 cancer dMMR who received radical surgery were collected from three Chinese centers between August 2012 January 2018. Overall (OS) was assessed Kaplan-Meier method log-rank. Cox regression analysis used assess influencing prognosis factors. The median follow-up for all 45.0 months (range,...
We evaluated the prognostic role of deficient mismatch repair (dMMR) systems in stage II and III colon cancer patients during different postoperative periods. also assessed whether aged ≥75 could benefit from chemotherapy.This retrospective study was conducted across three medical centers China. Kaplan-Meier survival methods Cox proportional hazards models were used to evaluate differences overall (OS) disease-free (DFS) rates. Propensity score matching performed reduce imbalances baseline...
Abstract Background : Colorectal cancer (CRC) is one of the most common cancers and associated with high incidence mortality rates around world. It has brought tremendous losses to human health wealth. Young adults are experiencing a rise in colorectal carcinoma. Early detection prevention made possible through screening. At present, faecal immunochemical test (FIT) noninvasive method that can be used for large-scale clinical screening CRC status. Therefore, this study, based on results...
Abstract Background and study aims Although ulcerative colitis (UC) incidence is increasing in China, there are few reports on risk factors. We conducted a case‒control Tianjin, to assess potential factors for the development, extent severity of UC. Methods 361 UC patients 1444 controls with similar social backgrounds were screened by detailed questionnaires corresponding endoscopic findings Tianjin's colorectal cancer screening program from 2012 2020. Basic demographic characteristics...