A5101863230- Ubiquitin and proteasome pathways
- Viral gastroenteritis research and epidemiology
- Ocular Diseases and Behçet’s Syndrome
- Cancer-related cognitive impairment studies
- Blood groups and transfusion
- Wnt/β-catenin signaling in development and cancer
- Liver Disease Diagnosis and Treatment
- Potato Plant Research
- Mosquito-borne diseases and control
- Hepatitis B Virus Studies
- Amino Acid Enzymes and Metabolism
- Histone Deacetylase Inhibitors Research
- Intensive Care Unit Cognitive Disorders
- Pancreatic function and diabetes
- Peptidase Inhibition and Analysis
- Hemoglobinopathies and Related Disorders
- Metabolism and Genetic Disorders
- Bipolar Disorder and Treatment
- Cancer-related gene regulation
- Electrolyte and hormonal disorders
- Viral Infections and Vectors
- Dialysis and Renal Disease Management
- Dementia and Cognitive Impairment Research
Peking University
2021-2025
King University
2025
Fujian University of Traditional Chinese Medicine
2025
Hunan Provincial Maternal and Child Health Hospital
2024
Jiangmen Central Hospital
2021
Taihe Hospital
2020
Hubei University of Medicine
2020
ABSTRACT Oral nucleotide analogues (NAs) and peginterferon‐α injections are commonly used for the treatment of patients with chronic hepatitis B (CHB). This study aims to evaluate effects different antiviral therapies on degree liver inflammation fibrosis in CHB patients. was a retrospective cohort study. A total 101 were admitted Liver Center Xiamen Hospital Traditional Chinese Medicine from 2017 2021 divided into three groups treatments: NAs therapy group ( n = 36), 38) nonantiviral 27)....
Ganoderic acid, isolated from Ganoderma lucidum , significantly ameliorated 5-FU induced cognitive impairment via preventing mitochondrial and enhancing neuronal survival growth.
y. Objective. To examine the effect of BRD4 inhibitor JQ1 on mice with chronic obstructive pulmonary disease (COPD) via NF-κB. Methods. COPD models constructed by exposure to cigarette smoke and intratracheal instillation lipopolysaccharides (LPS) in were treated (15, 25 or 50 mg/kg). HE staining was performed observe histopathological changes lung tissues. Enzyme-linked immunosorbent assays (ELISAs) used measure levels IL-10, IFN-γ, IL-17, IL1β, IL-6, TNF-α, MMP-2, MMP-9, MDA, SOD,...
Chronic kidney disease (CKD) with anxiety disorder is of a great concern due to its high morbidity and mortality. Urea, as an important toxin in CKD, not only pathological factor for complications patients but also accumulated the brain aging neurodegenerative diseases. However, role underlying regulatory mechanism urea CKD related mood disorders have been well established. We previously reported depression phenotype mice abnormal metabolism. Since are more likely suffer from anxiety, we...
HBV-infected individuals are also presenting with MASLD. However, the value of VCTE for detecting hepatic fibrosis and steatosis in CHB patients concurrent MASLD is unclear. In combined MASLD, we intend to assess diagnostic efficacy determining extent steatosis.
Urea's transmembrane transport through urea transporters (UT) is a fundamental physiological behavior for life activities. Here, we present 11 cryo-EM structures of four UT members in resting states, or inactive states bound with synthetic competitive, uncompetitive noncompetitive inhibitor. Our results indicate that the binding via conserved recognition motif (URM) and H-bond transfer along Q
Cleavage factor Im 25 (CFIm25) affects the prognosis and progression of cancer by regulating alternative polyadenylation; however, its role in colorectal remains unclear.A standard EnVision tissue microarray was used to evaluate expression CFIm25 immunohistochemistry 363 patients with cancer. The correlation between clinicopathological characteristics analyzed using χ2 test. Univariate analysis study relationship patient prognosis. Multivariate performed Cox regression model identify...