A5101896176- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Dementia and Cognitive Impairment Research
- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Neurological and metabolic disorders
- Geriatric Care and Nursing Homes
- Genetics and Neurodevelopmental Disorders
- Prenatal Screening and Diagnostics
- Multiple Sclerosis Research Studies
- Heat shock proteins research
- Glycogen Storage Diseases and Myoclonus
- Ear and Head Tumors
- Genetic Syndromes and Imprinting
- Genetic Neurodegenerative Diseases
- Cardiac Imaging and Diagnostics
- Caveolin-1 and cellular processes
- Prion Diseases and Protein Misfolding
- Neuroscience and Neural Engineering
- Vascular Anomalies and Treatments
- Connexins and lens biology
- Drug-Induced Ocular Toxicity
- Acute Lymphoblastic Leukemia research
- Congenital Ear and Nasal Anomalies
- Chromosomal and Genetic Variations
Kagoshima University
2020-2025
Okayama University
2013-2023
National Center of Neurology and Psychiatry
2022-2023
Hiroshima City Asa Citizens Hospital
2023
Tokushima University
2014-2019
Kumamoto University
1998
Nagasaki Medical Center
1993
Tohoku University
1970
Background.Family members providing daily care for older adults often experience a substantial burden.The Burden Scale Family Caregivers (BSFC) measures the total burden of caregiving across multiple dimensions and has been translated into languages.This study aimed to develop Japanese version BSFC short form (BSFC-s) then examine its reliability validity.Methods.An online survey targeting 6000 aged ≥65 years was conducted.Among these individuals, 339 reported that they currently family...
Mitochondria dynamically change their shape through frequent fusion and fission to continuously perform function in the cell. Although a mitochondrial morphology was reported amyotrophic lateral sclerosis (ALS), detailed changes of proteins have not been ALS model mice. In transgenic (Tg) mice with G93A human SOD1 mutation (G93ASOD1), both (Mfn1 Opal) (Drp1 Fis1) showed significant increase anterior half lumbar spinal cord. Such Tg were already noticeable at presymptomatic 10 week (W)...
The world is rapidly aging, and facing an increase of late-elderly dementia patients. It important to investigate the characteristic features in a super-aged country.We examined 1554 patients with cognitive decline Department Neurology, Okayama University Hospital, Okayama, Japan, divided into three subgroups according age: young-elderly (age ≤64 years), middle-elderly 65-74 years) 75 investigated cognitive, affective activities daily living functions (ADL), especially compared...
Amyotrophic lateral sclerosis (ALS) is characterized by progressive loss of motor neurons. Multilineage-differentiating stress-enduring (Muse) cells are unique endogenous stem that show therapeutic effects on function in ALS mouse models. We conducted a single-center open phase II clinical trial to evaluate the safety and repeated intravenous injections an allogenic Muse cell-based product, CL2020, patients with ALS. Five received CL2020 intravenously once month for total six doses. The...
An 11-year-old girl with de novo r(15) Ip12q26.3) a clinical diagnosis of Silver-Russell syndrome (SRS) is presented. She had prenatal and postnatal growth deficiency severe short stature, peculiar facies characterized by triangular face, pinched nose anteverted nostrils down-turned corners the mouth, bilateral clinodactyly fifth fingers, café-au-lait nevi, mental retardation, high level seurm follicular stimulating hormone. Southern blot analysis chromosome fluorescence in situ...
We herein report the case of a 60-year-old man showing overexpression creatine kinase (hyperCKemia) related to initial and recurrent attacks neuromyelitis optica (NMO). He showed reduced vision, ataxia dysesthesia, but no symptoms originating in muscles. Magnetic resonance imaging (MRI) revealed lesions optic nerve, medulla oblongata, spinal cord similar typical NMO patients. However, femoral MRI whole positron emission tomography (PET) demonstrated abnormal findings during an episode...
Recent genetic studies yielded conflicting results regarding a role for the variant chromogranin B (CHGB)P413L allele as disease modifier in ALS. Moreover, potential deleterious effects of CHGBP413L ALS pathology have not been investigated. Here we report that transfected cultured cells, CHGBL413 protein exhibited aberrant properties including mislocalization, failure to interact with mutant superoxide dismutase 1 (SOD1) and defective secretion. The transgene SOD1G37R mice precipitated onset...
In the brain after infarction or trauma, tissue becomes pannecrotic and forms a cavity. such situation, scaffold is necessary to produce new tissue. this study, we implanted porous gelatin-siloxane hybrid derived from gelatin 3-(glycidoxypropyl) trimethoxysilane (gelatin-GPTMS) scaffolds into defect, investigated whether it makes addition, vascular endothelial growth factor (VEGF) was added on gelatin- GPTMS its effect regeneration examined. At 30 days implantation, marginal territory of...
We describe a case of very unusual complication following coiling procedure in which the patient developed transient unique cerebral and cerebellar lesions. Lesions were examined not only by magnetic resonance imaging (MRI) but also positron emission tomography-computed tomography (PET-CT) proton spectroscopy ((1)H-MRS).A 33-year-old woman presented an incidental 3.7 × 3.3-mm unruptured aneurysm (CAn) her basilar artery, was successfully coiled with balloon assistance. A follow-up brain MRI...
Tocilizumab (TCZ; Actemra/RoActemra) is an anti-interleukin (IL)-6 receptor antibody for the treatment of rheumatoid arthritis (RA) and other autoimmune diseases cytokine storms. The present case a 63-year-old female well-controlled RA patient, who presented with progressive cognitive impairment after 34 months TCZ administration. Brain magnetic resonance imaging (MRI) showed leukencephalopathy lactic acid peak in spectroscopy (MRS), decreased blood flow single photon emission computed...
The needs and importance of the simple screening examination for dementia have risen recently. In present study, we corrected patients Alzheimer's disease, performed standard a computerized touch panel-type test early diagnosis (touch test), compared scores. There is good correlation MMSE score by single regression analysis. And so, very useful assessment dementia.
The variability of the lengths heterochromatic and euchromatic segments human Y chromosome was studied by a quantitative method densitometric measurement in 60 normal unrelated black individuals (30 with 30 without devotional surnames), living Salvador, Bahia, northeastern Brazil. Thirty Caucasian European origin, Curitiba, Paraná, south Brazil, were included as controls. segment total greater caucasians than blacks surnames, these surnames. These findings are agreement previous reports...
An 86-year-old man was admitted to another hospital with ataxia and general fatigue. Brain MRI scan revealed a high-intensity area in the bilateral thalamus, he referred Okayama University Hospital for detailed examination. Cerebrospinal fluid (CSF) blood tests showed no evidence of infection or autoimmune encephalitis. FDG-PET/CT systemic lymphadenopathy, cervical lymph node biopsy classical Hodgkin lymphoma. Neurological symptoms were suspicious paraneoplastic neurological syndrome (PNS),...
Abstract Focal and segmental areas of glomerular sclerosis (FSGS) have various subcategories. Here, we report on a 35‐year‐old man who suffered from Charcot‐Marie‐Tooth disease (CMT) with FSGS carrying the INF2 mutation (c.206 T > C, p.L69P). The might cause abnormal actin filaments podocytes Schwann cells, leading to CMT associated FSGS. He successfully underwent living donor kidney transplantation mother normal gene without any serious adverse events. Following genetic testing,...
Abstract Immune checkpoint inhibitors occasionally cause various side effects, but the occurrence of a severe immune‐related adverse event (irAE) is rare in neurology. We report on 56‐year‐old woman who suffered from rheumatoid arthritis and recurrent uterine cancer. After treatment with pembrolizumab, she showed visual disturbance followed by acute fever consciousness high‐intensity lesions around midbrain aqueduct bilateral caudate heads FLAIR images brain MRI. Her symptoms improved after...
Abstract Glial fibrillary acidic protein (GFAP) astrocytopathy is a novel autoimmune meningoencephalomyelitis. Case 1 26–year‐old (yo) woman with bilateral ovarian teratoma. She presented neck stiffness, hyperreflexia, postural tremor, and urinary retention. Three courses of methylprednisolone pulse subsequent enucleation the teratoma improved her neurological symptoms no recurrence. 2 46‐year‐old man who showed infectious‐like elevated creatine kinase. 3 76‐year‐old preceding weight loss,...