A5020332310- Thermoregulation and physiological responses
- Infrared Thermography in Medicine
- Peripheral Neuropathies and Disorders
- Autoimmune Neurological Disorders and Treatments
- Exercise and Physiological Responses
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Parkinson's Disease Mechanisms and Treatments
- Clinical Nutrition and Gastroenterology
- Helicobacter pylori-related gastroenterology studies
- Heart Rate Variability and Autonomic Control
- Multiple Sclerosis Research Studies
- Gastroesophageal reflux and treatments
- Organ Transplantation Techniques and Outcomes
- Building Energy and Comfort Optimization
- Color perception and design
- Appendicitis Diagnosis and Management
- Amyotrophic Lateral Sclerosis Research
- Genetic Neurodegenerative Diseases
- Hereditary Neurological Disorders
- Diabetes and associated disorders
- Non-Invasive Vital Sign Monitoring
- Textile materials and evaluations
- Skin Protection and Aging
- Lipid metabolism and disorders
Okayama University
2015-2024
Tokyo Gas (Japan)
2005-2022
Jikei University School of Medicine
2008
Tohoku University
2004-2005
Okayama Central Hospital
2005
Miyagi Children's Hospital
2004
Kobe University Hospital
2002-2003
Kobe Pharmaceutical University
2001
This study was conducted to examine the disproportionality, times onset, incidence rates, and outcomes of sorafenib-associated cardiac AEs, using Japanese Adverse Drug Event Report database. We analyzed data for period between April 2004 May 2023. Data on AEs were extracted relative disproportionality estimated reporting odds ratios (RORs). 2,230,863 reports identified 8,374 associated with sorafenib, including 318 AEs. Signals detected seven AEs: hypertension, failure congestive, myocardial...
Amyotrophic lateral sclerosis (ALS) is characterized by progressive loss of motor neurons. Multilineage-differentiating stress-enduring (Muse) cells are unique endogenous stem that show therapeutic effects on function in ALS mouse models. We conducted a single-center open phase II clinical trial to evaluate the safety and repeated intravenous injections an allogenic Muse cell-based product, CL2020, patients with ALS. Five received CL2020 intravenously once month for total six doses. The...
Objective The increasing population of elderly people in Japan has accelerated the demand for a simple screening test to detect cognitive and affective declines mild impairment (MCI) early stage dementia. Methods We compared functions, activities daily living (ADLs) results four computerized touch-panel tests 41 MCI subjects, 124 patients with Alzheimer's disease (AD) 75 age- gender-matched normal controls. Results All games were successfully used discriminate AD from controls (** p<0.01)....
A series of clinical studies on the cytochrome P450 2C19 (CYP2C19) genotype and pharmacokinetics pharmacodynamics three proton pump inhibitors (PPIs), omeprazole, lansoprazole rabeprazole, have been conducted to establish individualized pharmacotherapy based CYP2C19 genotyping, in present study, genotype-dependency was more pronounced for omeprazole than other two. Herein, validate further difference among 3 PPIs phenotype, a comparative vitro study using human liver microsomes newly...
In anti-Helicobacter pylori therapy using omeprazole and antimicrobials, the efficacy can be related to CYP2C19 genotype groups; eradication rates were 83% in extensive metabolizers 100% poor metabolizers. The present study was undertaken help predict optimal dosage of for this therapy. Seven healthy Japanese subjects, classified based on into (n=4) (n=3), participated study. Each subject received a single oral dose 20, 40, 80 mg, with at least 1-week washout period between each dose. Plasma...
Objective Cognitive and affective dysfunctions are important aspects for patients with multiple sclerosis (MS) neuromyelitis optica (NMO). Methods We herein examined the cognitive ability in MS (n=35) NMO (n=10) using computerized touch panel-type screening tests. Results While normal controls (NC1, n=40) did not significantly differ their scores from Hasegawa dementia scale-revised (HDS-R) or frontal assessment battery, score lower on mini-mental state examination (MMSE). In contrast,...
Summary Background : The polymorphic enzyme cytochrome P450 2C19 affects omeprazole metabolism. This influence on metabolism might affect serum gastrin levels, and safety, during long‐term treatment of reflux oesophagitis. Aim To examine the relationship between genotype safety profile treatment. Methods A total 119 Japanese patients with recurrent oesophagitis underwent genotyping prior to receiving daily 10 mg or 20 for 6–12 months, which adverse event frequency, levels endoscopic findings...
To test the hypothesis that mist sauna is a safer way of bathing than dry sauna, we compared changes in circulatory and thermoregulatory functions during 10 min at 40℃ with relative humidity 100%, by infrared ray 70℃ 15%. Subjects were seven healthy young men aged 29 ± 6 yrs (mean SD). We measured blood pressure, heart rate, skin temperatures chest, forearm, thigh, leg, tympanic temperature (Tty) thermistors, flow forearm laser Doppler flowmetry, sweat rate ventilated capsule method 1...
We describe a case of very unusual complication following coiling procedure in which the patient developed transient unique cerebral and cerebellar lesions. Lesions were examined not only by magnetic resonance imaging (MRI) but also positron emission tomography-computed tomography (PET-CT) proton spectroscopy ((1)H-MRS).A 33-year-old woman presented an incidental 3.7 × 3.3-mm unruptured aneurysm (CAn) her basilar artery, was successfully coiled with balloon assistance. A follow-up brain MRI...
Abstract HF and LF/HF, which are parameters of the frequency domain electrocardiogram R‐R interval time series, general index autonomic nervous activity balance. Most wristwatch‐type heart‐rate monitors measure heart rate from sphygmograph interpolate missing data. These causes reducing calculation accuracy LF HF. The purpose this study is to propose a method for estimating calculated ECG series at 1‐s intervals measured by monitor. Six hundred seventy data‐set with length 120 s...
Oil-in-water lipid emulsions are promising drug carriers for lipophilic drugs, however, the pharmacokinetics after entering circulation should be clarified at clinical injection volume in order to utilize them a situation. In present study, standard emulsions, consisting of soybean oil, egg yolk phosphatides and menatetrenone with diameters about 150nm, were prepared using microfluidizer system. The oil particles intravenous as various volumes, from (0.1 ml/kg) experimental (3.0 ml/kg),...
Mist sauna is a style of bathing in which hot water vapor sprayed into bathroom, establishing an air temperature 40°C with saturated humidity.Bath heater and dryer equipment mist function was released onto the Japanese market 2004.After their introduction, various studies investigated effects bathing, it has been demonstrated that efficacies, not only hyperthermic but also other including on physical appearance.Mist occurs usually without toilet, room approximately 100% relative humidity.It...
Surgery is currently the mainstay of treatment for intra-abdominal abscess, although operative mortality high [1]. Percutaneous drainage another option but associated with significant morbidity due to relatively long route used catheter placement [1] [2]. Endoscopic ultrasound (EUS)-guided potentially safe and effective abscess. We report a case omental bursa abscess complicating appendicitis diffuse peritonitis that was successfully safely drained under EUS guidance.