A5090097137- Zeolite Catalysis and Synthesis
- Mesoporous Materials and Catalysis
- Peripheral Neuropathies and Disorders
- Hereditary Neurological Disorders
- Autoimmune Neurological Disorders and Treatments
- Neurogenetic and Muscular Disorders Research
- CNS Lymphoma Diagnosis and Treatment
- Renal and related cancers
- Cerebrospinal fluid and hydrocephalus
- Conducting polymers and applications
- Restless Legs Syndrome Research
- Antifungal resistance and susceptibility
- MRI in cancer diagnosis
- Viral-associated cancers and disorders
- Neurological and metabolic disorders
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Amyotrophic Lateral Sclerosis Research
- Genetics and Neurodevelopmental Disorders
- Parkinson's Disease Mechanisms and Treatments
- Radiopharmaceutical Chemistry and Applications
- Peptidase Inhibition and Analysis
- Pain Mechanisms and Treatments
- Tuberous Sclerosis Complex Research
- Brain Metastases and Treatment
Okayama University
2021-2025
Aichi Institute of Technology
2023-2024
Hiroshima City Asa Citizens Hospital
2021-2023
National Center of Neurology and Psychiatry
2023
ABSTRACT We present a case of male patient with disease‐causing variants in SPG11 , causative gene for autosomal recessive spastic paraplegia thin corpus callosum (ARHSP‐TCC), as well juvenile amyotrophic lateral sclerosis (ALS5) and Charcot–Marie–Tooth disease (CMT2X). A neurological examination at age 18 revealed dysarthria, muscle weakness bilateral lower extremities, hyperreflexia patellar reflex, hyporeflexia Achilles reflex an extensor plantar intellectual disability. Magnetic...
Amyotrophic lateral sclerosis (ALS) is characterized by progressive loss of motor neurons. Multilineage-differentiating stress-enduring (Muse) cells are unique endogenous stem that show therapeutic effects on function in ALS mouse models. We conducted a single-center open phase II clinical trial to evaluate the safety and repeated intravenous injections an allogenic Muse cell-based product, CL2020, patients with ALS. Five received CL2020 intravenously once month for total six doses. The...
Central nervous system methotrexate-associated lymphoproliferative disorder (CNS-MTX-LPD) is rare, but its spontaneous regression has been observed in some patients after withdrawal of agents. We herein report three cases primary CNS-MTX-LPD that received oral MTX for rheumatoid arthritis. Epstein-Barr virus and oligoclonal bands (OCBs) were positive, while proton magnetic resonance spectroscopy (1H-MRS) showed an elevated lipid peak slightly choline/N-acetylaspartate ratio common. After...
Zeolite-templated carbons (ZTCs) are widely studied from basic research to applied owing their characteristic pore structures. To synthesize ZTCs, smaller molecules than the sizes of template zeolites...
Abstract We report on a 35‐year‐old man who had gender dysphoria following unilateral ovariectomy and then received continuous testosterone injection for nine years, inducing chronic inflammatory demyelinating polyneuropathy (CIDP). He developed recurrent muscle weakness numbness in the extremities displayed neuropathy, detected by nerve conduction studies sural biopsy. Repeated intravenous immunoglobulin (IVIg) therapy administration of oral prednisolone improved symptoms inhibited their...
Abstract Objectives The aim was to determine the amplitude changes in repetitive nerve stimulation (RNS) decrement values after fast‐acting treatments (FTs), including plasmapheresis, high‐dose intravenous methylprednisolone and immunoglobulin, patients with myasthenia gravis (MG). Methods We retrospectively enrolled 41 MG who received RNS FT. median, ulnar, facial, accessory axillary nerves were tested. An improvement quantitative score of ≥3 or activities daily living scale ≥2 used define...
Abstract Focal and segmental areas of glomerular sclerosis (FSGS) have various subcategories. Here, we report on a 35‐year‐old man who suffered from Charcot‐Marie‐Tooth disease (CMT) with FSGS carrying the INF2 mutation (c.206 T > C, p.L69P). The might cause abnormal actin filaments podocytes Schwann cells, leading to CMT associated FSGS. He successfully underwent living donor kidney transplantation mother normal gene without any serious adverse events. Following genetic testing,...
Abstract Immune checkpoint inhibitors occasionally cause various side effects, but the occurrence of a severe immune‐related adverse event (irAE) is rare in neurology. We report on 56‐year‐old woman who suffered from rheumatoid arthritis and recurrent uterine cancer. After treatment with pembrolizumab, she showed visual disturbance followed by acute fever consciousness high‐intensity lesions around midbrain aqueduct bilateral caudate heads FLAIR images brain MRI. Her symptoms improved after...
Abstract Glial fibrillary acidic protein (GFAP) astrocytopathy is a novel autoimmune meningoencephalomyelitis. Case 1 26–year‐old (yo) woman with bilateral ovarian teratoma. She presented neck stiffness, hyperreflexia, postural tremor, and urinary retention. Three courses of methylprednisolone pulse subsequent enucleation the teratoma improved her neurological symptoms no recurrence. 2 46‐year‐old man who showed infectious‐like elevated creatine kinase. 3 76‐year‐old preceding weight loss,...
Myoclonus, a rare complication in patients with end-stage renal disease, is typically ameliorated through hemodialysis. The present case concerns an 84-year-old male chronic failure undergoing hemodialysis, presenting involuntary movements his limbs, which gradually worsened from the initiation of hemodialysis without constant elevation serum blood urea nitrogen and electrolytes levels. Surface electromyography revealed characteristic findings consistent myoclonus. He was diagnosed...
Abstract Anti‐glutamic acid decarboxylase (GAD) antibody (Ab)‐associated autoimmune cerebellar ataxia (CA) is a rare neurological disorder, and standardized therapy has not been established. Here, we report on 58 year‐old man with type 1 diabetes mellitus, who developed progressive CA high levels of serum cerebrospinal fluid (CSF) anti‐GAD‐Ab. He was initially treated intravenous high‐dose methylprednisolone immunoglobulin (IVIg), but his gradually worsened. Additional combined...