A5100403841- Viral Infectious Diseases and Gene Expression in Insects
- Microbial Metabolic Engineering and Bioproduction
- Genomics and Phylogenetic Studies
- Identification and Quantification in Food
- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
- interferon and immune responses
- Chemical Synthesis and Analysis
- Biofuel production and bioconversion
- Viral-associated cancers and disorders
- DNA and Nucleic Acid Chemistry
- Plant Disease Resistance and Genetics
- Gene Regulatory Network Analysis
- Cytomegalovirus and herpesvirus research
- Protein purification and stability
- Traditional Chinese Medicine Studies
- Microbial Natural Products and Biosynthesis
- RNA Interference and Gene Delivery
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- Aquaculture disease management and microbiota
- Free Radicals and Antioxidants
- Biochemical effects in animals
- Proteoglycans and glycosaminoglycans research
- Congenital heart defects research
University of South Florida
2021-2024
Southwest Forestry University
2021-2024
State Key Laboratory of Oral Diseases
2018-2023
Third Xiangya Hospital
2023
Central South University
2023
Institute of Biophysics
2023
Chinese Academy of Sciences
2023
Sichuan University
2018-2023
Shenyang Agricultural University
2015-2022
University of Wisconsin–Madison
2010-2021
Abstract Imbalance of macrophage polarization characterized by an increase in the percentage pro‐inflammatory M1 macrophages and a decrease anti‐inflammatory M2 is considered critical pathogenic mechanism bisphosphonate‐related osteonecrosis jaws (BRONJ). Because high levels Toll‐like receptor 4 (TLR4) mediates mitochondrial dyshomeostasis Zoledronic Acid (ZA)‐treated macrophages, tetrahedral DNA nanomaterial (TDN)‐modified with TLR4‐siRNA on each vertex (TDN‐TLR4‐4siR) excellent...
Shewanellae are gram-negative facultatively anaerobic metal-reducing bacteria commonly found in chemically (i.e., redox) stratified environments. Occupying such niches requires the ability to rapidly acclimate changes electron donor/acceptor type and availability; hence, compete thrive environments must ultimately be reflected organization utilization of transfer networks, as well central peripheral carbon metabolism. To understand how Shewanella oneidensis MR-1 utilizes its resources,...
Mongolian oak (Quercus mongolica Fisch.) is an ecologically and economically important white species native to widespread in the temperate zone of East Asia. Here, we present a chromosome-scale reference genome assembly Q. mongolica, representative species, by combining Illumina PacBio data with Hi-C mapping technologies that first created for Asian oak. Our results showed draft size was 809.84 Mb, BUSCO complete gene percentage 92.71%. scaffolding anchored 774.59 Mb contigs (95.65%...
Gastric cancer is the second leading cause of death from worldwide, with an approximately 20% 5‐year survival rate. To identify molecular subtypes associated clinical prognosis, in addition to genetic aberrations for potential targeted therapeutics, we conducted a comprehensive whole‐genome analysis 131 Chinese gastric tissue specimens using array comparative genomic hybridization. The analyses revealed gene focal amplifications, including CTSB , PRKCI PAK1 STARD13, KRAS and ABCC4 ERBB2...
J. Neurochem. (2012) 120 , 842–849. Abstract Endocannabinoids are neuromodulatory lipids that mediate the central and peripheral neural functions. have demonstrated their anti‐proliferative, anti‐angiogenic pro‐apoptotic properties in a series of studies. In present study, we investigated levels two major endocannabinoids, anandamide 2‐arachidonylglycerol (2‐AG), receptors, CB1 CB2, human low grade glioma (WHO I‐II) tissues, high III‐IV) non‐tumor brain tissue controls. We also measured...
Symbiotic interactions between organisms are important for human health and biotechnological applications. Microbial mutualism is a widespread phenomenon in maintaining natural microbial communities. Although cooperative prevalent nature, little known about the processes that allow their initial establishment, govern population dynamics affect evolutionary processes. To investigate bacteria, we constructed, characterized, adaptively evolved synthetic community comprised of leucine lysine...
The problem of tissue vascularization is one the obstacles that currently restricts application engineering products to clinic. Achieving and providing adequate nutrients for tissues are an urgent build complex effective tissue-engineered organs. Therefore, aim this study was investigate effect tetrahedral DNA nanostructures (TDNs), a novel biocompatible nanomaterial, on angiogenesis. results showed TDNs can enter into endothelial cells (ECs) promote EC proliferation, migration, tube...
Interferons (IFNs) and the products of interferon-stimulated genes (ISGs) play crucial roles in host defense against virus infections. Although many ISGs have been characterized with respect to their antiviral activity, target specificities mechanisms action remain largely unknown. Kaposi’s sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that linked several human malignancies. Here, we used genetically biologically related virus, murine 68 (MHV-68) screened for...
pH control is critical in bioreactor operations, typically realized through a two-sided loop, where CO2 sparging and base addition are used bicarbonate-buffered media. Though common approach, could compromise culture performance due to the potential impact from excursions osmolality increase large-scale bioreactors. In this study, feasibility of utilizing sparge gas composition as part loop was assessed Chinese hamster ovary (CHO) fed-batch cultures. Fine evaluated multiple processes at...
Abstract Recent progress in metabolic engineering and synthetic biology enables the use of microorganisms for production chemicals—“bio‐based chemicals.” However, it is still unclear which chemicals have highest economic prospect. To this end, we develop a framework identification such promising ones. Specifically, first genome‐scale constraint‐based modeling approach, used to identify candidate pool 209 (together with estimated yield, productivity, residence time each) from intersection...
Genetic amplification of HER2 drives tumorigenesis and cancer progression in a subset patients with gastric (GC), treatment trastuzumab, humanized HER2-neutralizing antibody, improves the overall survival rate HER2-positive patients. However, considerable portion does not respond to trastuzumab molecular mechanisms underlying intrinsic resistance anti-HER2 therapy GC is fully understood. We performed whole-transcriptome sequencing on 21 tumor specimens from Chinese Whole genome was three...
The adenovirus E1A-associated protein p300 is a transcriptional cofactor that interacts with YY1 and mediates the relief of repression by E1A. These observations raise possibility may function as bridging factor between E1A cellular transcription factors. Here we show p300, but not mutant defective for binding to E1A, activated cAMP-responsive element-binding protein/activating (CREB/ATF) site-mediated in presence Among proteins can recognize CREB/ATF site, CREB appeared be modulated...
Abstract Chinese hamster ovary (CHO) cells are the primary host for manufacturing of therapeutic proteins. However, productivity loss is a major problem and associated with genome instability, as chromosomal aberrations reduce transgene copy number decrease protein expression. We analyzed whole‐genome sequencing data from 11 CHO cell lines found deleterious single‐nucleotide variants in DNA repair genes. Comparison confirmed to be compromised CHO. Correction key genes by variant reversal or...
Recently, the C1019T polymorphism in human gene encoding connexin 37 (CX37, encoded by GJA4) has been reported to be associated with coronary artery disease (CAD)/myocardial infarction different racial groups, but no data are currently available northern Han Chinese. The aim of our study is investigate association between 3 GJA4 polymorphisms (-1930C/T, and I1297D) susceptibility CAD Chinese.502 patients 410 controls confirmed angiography were genotyped polymerase chain reaction restriction...
Protein 4.1R, an 80 000 MW membrane skeleton protein, is a vital component of the red blood cell cytoskeleton that stabilizes spectrin-actin network and regulates properties deformability mechanical stability. It has been shown 4.1R expressed in T cells, including CD8+ but its role cells remains unclear. Here, we have explored using 4.1R-/- mice. Our results showed activation, proliferation secretion levels interleukin-2 interferon-γ were significantly increased cells. Furthermore,...