A5088174346- Meningioma and schwannoma management
- Pituitary Gland Disorders and Treatments
- Glioma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Cerebrospinal fluid and hydrocephalus
- Intracranial Aneurysms: Treatment and Complications
- Neurofibromatosis and Schwannoma Cases
- Vascular Malformations Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Bone Tumor Diagnosis and Treatments
- Spinal Dysraphism and Malformations
- CNS Lymphoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Cerebral Venous Sinus Thrombosis
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Neonatal and fetal brain pathology
- Fetal and Pediatric Neurological Disorders
- Heat shock proteins research
- Neonatal Respiratory Health Research
- Teratomas and Epidermoid Cysts
- Intracerebral and Subarachnoid Hemorrhage Research
- Peripheral Neuropathies and Disorders
- Facial Nerve Paralysis Treatment and Research
Fujian Medical University
2015-2025
First Affiliated Hospital of Fujian Medical University
2015-2025
Capital Medical University
2024
Beijing Institute of Neurosurgery
2024
Creative Commons
2014
Imaging Center
2014
Surgical management of giant and irregular pituitary neuroendocrine tumors (GIPitNETs) presents a significant challenge in neurosurgery. While endoscopic endonasal surgery (EES) is widely used approach for PitNETs, GIPitNETs with extensive intracranial extension pose challenges purely EES. We use simultaneous combined transcranial (CECS) the treatment this type tumor. Currently, there limited research comparing CECS to EES GIPitNETs. This study aims compare efficacy short outcome better...
J. Neurochem. (2012) 120 , 842–849. Abstract Endocannabinoids are neuromodulatory lipids that mediate the central and peripheral neural functions. have demonstrated their anti‐proliferative, anti‐angiogenic pro‐apoptotic properties in a series of studies. In present study, we investigated levels two major endocannabinoids, anandamide 2‐arachidonylglycerol (2‐AG), receptors, CB1 CB2, human low grade glioma (WHO I‐II) tissues, high III‐IV) non‐tumor brain tissue controls. We also measured...
Calcification of adamantinomatous craniopharyngioma (ACP) often causes problems with tumor resection, leading to a high incidence deadly complications and recurrence. Histone acetyltransferase (HAT) histone deacetylase (HDAC) are 2 key enzymes that regulate acetylation play important roles in development. However, the HAT HDAC calcification osteoblastic differentiation ACP not known.In this study, primary cells were isolated from tissues, was induced bone morphogenetic protein (Bmp2). HDAC3...
Background: Surgical treatment of complex giant pituitary adenomas (GPAs) presents significant challenges. The efficacy and safety combining transsphenoidal transcranial approaches for these tumors remain controversial. In this largest cohort patients with GPAs, we compared the surgical outcomes between those undergoing a combined regimen non-combined regimen. We also examined differences in risks complications, costs, logistics two groups, which might offer valuable information appropriate...
Neuronavigation and classification of craniopharyngiomas can guide surgical approaches prognostic information. The QST has been developed according to the origin craniopharyngiomas; however, accurate preoperative automatic segmentation remain challenging. This study aimed establish a method automatically segment multiple structures in MRIs, detect craniopharyngiomas, design deep learning model diagnostic scale for classification.We trained network based on sagittal MRI six tissues, including...
Background and Purpose- Hypoxic-ischemic brain damage is a well-recognized physiopathologic mechanism after aneurysmal subarachnoid hemorrhage (aSAH). The Ngb (neuroglobin) hemoprotein predominantly expressed in the with high affinity for oxygen. Relationship between serum level metabolism aSAH patients has not been investigated previously. Methods- Thirty-six consecutive severe (Glasgow Coma Scale score ≤8 on admission) multimodal neuromonitoring 36 matched healthy subjects were included....
Objective To investigate the clinicopathological characteristics, molecular genetic characteristics and prognosis of extraventricular neurocytoma located in sellar/suprasellar region. Methods Seven archived tumor samples derived from 4 patients with region were collected First Affiliated Hospital Fujian Medical University Qingdao retrospectively analyzed for clinical manifestations, imaging features, histopathological features. Neuronal pituitary biomarkers features detected these tissues by...
BACKGROUND:Controversies exist in imaging modalities for predicting adenoma consistency. In this study, we proposed a method of consistency by magnetic resonance T2-sequence based on to cerebellar peduncle signal (TCTI) ratio. MATERIAL AND METHODS:Between January 2013 and May 2017, 191 consecutive patients with pituitary diagnosed at our institution were retrospectively studied. The grade each lesion was assigned. And the TCTI ratio preoperative postoperative T2-weighted calculated....
Objective: Neuroendoscopic treatment is an alternative therapeutic strategy for the of septate chronic subdural hematoma (sCSDH). However, safety and efficacy this remain controversial. We compared clinical outcomes neuroendoscopic with those standard (large bone flap) craniotomy sCSDH reported in our center. Furthermore, procedure were evaluated. Methods: retrospectively collected data 43 patients (37 men six women) who underwent either or craniotomy, such as sex, age, smoking, drinking,...
BACKGROUND: The calcification of adamantinomatous craniopharyngioma (ACP) often creates difficulties for surgical therapy. Nevertheless, the mechanism ACP is unclear. Our previous studies demonstrated that osteoblastic factors might play important roles in calcification. OBJECT IVE: We examined effects recombinant human Bmp2 on cell differentiation by testing proteins and calcium deposition. METHODS: expression including osteopontin (OPN), Runx2, osterix Bmp2-treated cells was western blot...
Background: Studies investigating the change in distance between bilateral internal carotid arteries (ICAs) acromegalic patients have provided ambiguous results. The influencing factors of these changes not been well identified. Objective: To further investigate ICAs acromegaly and identify change. Method: Patients diagnosed as from Jan 2016 to Sep 2019 Department Neurosurgery First Affiliated Hospital Fujian Medical University, were included this study. Computed tomography angiography (CTA)...
Abstract Background To present a surgical technique for the treatment of intradural extramedullary (IDEM) tumors by using endoscopically controlled surgery with open hemilaminectomy technique. Methods In this study, 20 patients 22 IDEM were enrolled. An was employed to remove tumors. Data related clinical symptoms and medical images before after collected perioperative evaluation follow-up analysis. Results All in well removed. The significantly reduced all as well. short-term data showed...
<title>Abstract</title> <bold>Objective: </bold>Preoperative prediction of visual recovery after pituitary adenoma resection surgery remains challenging. This study aimed to investigate the value clinical and radiological features in preoperatively predicting outcomes surgery. <bold>Methods:</bold>Patients undergoing endoscopic transsphenoidal (ETS) for were included this retrospective prospective study. Preoperative MRI, acuity, field, postoperative data collected. Logistic regression...
Objective Preoperative prediction of visual recovery after pituitary adenoma resection surgery remains challenging. This study aimed to investigate the value clinical and radiological features in preoperatively predicting outcomes surgery. Methods Patients undergoing endoscopic transsphenoidal (ETS) for were included this retrospective prospective study. MRI, acuity, field, postoperative data collected. Logistic regression analysis was used assess importance MRI features, a model developed....
Objective: To investigate the clinicopathological features, immunophenotype, molecular characteristics and differential diagnosis of primary skull base chondrosarcoma. Methods: Nine cases chondrosarcoma were collected at First Affiliated Hospital Fujian Medical University, from January 2006 to June 2019, reviewed for clinical radiologic data morphologic immunophenotype characteristics. Results: Among all 9 cases, six male, three frmale, with average age 47 years, median years; five WHO...
Introduction: The purpose of this study was to verify whether the prevalence intracranial aneurysm (IA) in patients with acoustic neuroma is greater than that age- and sex-matched controls, evaluate independent risk factors related occurrence IA. Methods: We retrospectively analyzed 231 diagnosed at our institute between 2015 2019, 489 controls from medical examination center. Cerebrovascular angiography acquired all subjects assess presence IA or not. IA, associated a higher were compared,...