A5075533793- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- RNA regulation and disease
- Autophagy in Disease and Therapy
- Animal Genetics and Reproduction
- Sirtuins and Resveratrol in Medicine
- RNA Interference and Gene Delivery
- Endoplasmic Reticulum Stress and Disease
- CRISPR and Genetic Engineering
- interferon and immune responses
South China Agricultural University
2023-2024
The quality of oocytes determines their development competence, which will be rapidly lost if the are not fertilized at proper time after ovulation. SIRT1, one sirtuin family members, has been proven to protect during postovulatory oocyte aging. However, evidence effect SIRT1 on activity organelles including mitochondria, endoplasmic reticulum (ER), Golgi apparatus, and lysosomes in aging is lacking. In this study, we investigated distribution function aged discovered abnormalities....
Gender control technologies are promising for enhancing the production efficiency of farm animal industry, and preventing sex-linked hereditary diseases in humans. It has been shown that X sperm mammalian animals specifically expresses X-chromosome-derived toll-like receptor 7/8 (TLR7/8), activation TLR7/8 on by their agonist, R848, can separate Y via specific inhibition motility. The use R848-preselected fertilization resulted sex-ratio-skewed embryos or offspring. In this study, we aimed...
Technologies that can preselect offspring gender hold great promise for improving farm animal productivity and preventing human sex-related hereditary diseases. The maternal Rlim allele is required imprinted X-chromosome inactivation, which essential the normal development of female mouse embryos. In this study, we inactivated in embryos by crossing a male transgenic line carrying an X-linked CMV-Cre transgene with loxP-flanked gene. Knockout gene resulted male-biased sex ratio skew...