A5019399583- Olfactory and Sensory Function Studies
- Antibiotics Pharmacokinetics and Efficacy
- Multisensory perception and integration
- Biochemical Analysis and Sensing Techniques
- Antibiotic Resistance in Bacteria
- Visual perception and processing mechanisms
- Intensive Care Unit Cognitive Disorders
- Neurobiology and Insect Physiology Research
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Color perception and design
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Pneumonia and Respiratory Infections
- Liver Disease and Transplantation
- Neonatal Respiratory Health Research
- Cardiac, Anesthesia and Surgical Outcomes
- Pulmonary Hypertension Research and Treatments
- Antibiotic Use and Resistance
- Acute Kidney Injury Research
- Anesthesia and Neurotoxicity Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Sentiment Analysis and Opinion Mining
- Epilepsy research and treatment
- Analytical Methods in Pharmaceuticals
Hubei University
2018-2024
Nanjing Medical University
2023-2024
Nanjing Drum Tower Hospital
2011-2024
Dalian University of Technology
2024
Changshu No.1 People's Hospital
2018-2023
China Pharmaceutical University
2023
Changshu No. 2 People's Hospital
2021-2023
Xuzhou Medical College
2021-2023
Guangdong University of Foreign Studies
2022
China Medical University
2014-2021
To evaluate the impact and cost-benefit value of pharmacist interventions for prophylactic antibiotic use in surgical patients undergoing clean or clean-contaminated operations.
Physical exercise has been proved to reduce the risk of major depression in Subthreshold (StD) individuals effectively, yet little is known about spontaneous brain activity changes associated with physical exercise.A total 70 adult subjects, including 38 StD and 32 healthy control (HC) underwent a resting-state functional magnetic resonance imaging (rs-fMRI) before after eight-week aerobic respectively. Then, amplitude low-frequency fluctuation (ALFF) alterations between two groups were...
Abstract Purpose To analyze the risk factors influencing development of cefoperazone-induced coagulopathy in critically ill patients and determine threshold serum trough concentration. Methods A retrospective case-control study was conducted intensive care unit treated with cefoperazone, it approved by Ethical Committee Drum Tower Hospital affiliated Medical School Nanjing University (NO.2023-158-01). Patients were divided into normal group based on prothrombin time. The clinical...
Three motion-sensitive key elements of a neural circuit, presumably involved in processing object and distance information, were analyzed with optic flow sequences as experienced by blowflies three-dimensional environment. This is largely shaped the blowfly's saccadic flight gaze strategy, which separates translational segments from fast rotations. By modifying this naturalistic flow, all three neurons could be shown to respond during intersaccadic intervals not only nearby objects but also...
Abstract Culture may influence sensory perception and behavior. Earlier we have shown that circular shapes semantic familiar words enhance sweetness sensitivity with the Chinese volunteers. Do these effects also affect people from other cultural background? How does culture actually cross‐modal perception? Here, performed similar experiments Indian volunteers compared of vision on taste between two groups. The results show as group, sensitivities well, although their average threshold is...
To describe the pharmacokinetics/pharmacodynamics (PK/PD) of ceftazidime/avibactam in critically ill patients with CNS infections.
Many response characteristics of neurons sensitive to visual motion depend on stimulus history and change during prolonged stimulation. Although the changes are usually regarded as adaptive, their functional significance is still not fully understood. With experimenter-defined stimuli, previous research adaptation has mainly focused enhancing detection in domain, preventing output saturation energy efficient coding. Here we will analyze blowfly system under complex conditions encountered...
Previous literature reports have demonstrated that taste perception would be influenced by different internal brain status or external environment stimulation. Although there are hypotheses about the cross-modal interactive process, it still remains unclear as of how modulates and processes perception, particularly with memory load. Here in this study we address question. To do so assign participants loads form varying lengths alphanumerical items, before tasting concentrations sweet bitter...
Polymyxin B is served as a last-line agent for Carbapenem-resistant organisms (CRO) infections. This study aimed to establish population pharmacokinetic (PK) model in patients with/without continuous renal replacement therapy (CRRT), investigate the relationship between clinical covariates and polymyxin PK parameters, optimize dosing regimens. Blood samples were obtained each patient at steady state. The plasma concentrations of determined using high-performance liquid chromatography-tandem...
Vestibular compensation, which is the behavioral recovery from lesions to peripheral vestibular system, attributed plasticity of central system. It has been reported that brain‐derived neurotrophic factor ( BDNF ) expressed and released in an activity‐dependent manner. Upon binding tyrosine receptor kinase B (TrkB), can acutely modulate synaptic transmission nervous To assess possible contribution this process, we studied expression , TrkB. FL TrkB.T1 KCC 2 (K + ‐Cl − cotransporter isoform...
Cross-modal correspondence has been consistently evidenced between shapes and other sensory attributes. Especially, the curvature of may arouse affective account, which contribute to understanding mechanism cross-modal integration. Hence, current study used functional magnetic resonance imaging (fMRI) technique examine brain activity’s specificity when people view circular angular shapes. The consisted a circle an ellipse, while triangle star. Results show that areas activated by mainly...
It is still unclear how sensory systems efficiently encode signals with statistics as experienced by animals in the real world and what role adaptation plays during normal behavior. Therefore, we studied performance of visual motion-sensitive neurons blowflies, horizontal system neurons, optic flow that was reconstructed from head trajectories semi-free-flying flies. To test motion affected dynamics, manipulated seminatural targeted modifications flight assessed to extent neuronal responses...
Abstract In recent years, polymyxin B‐associated acute kidney injury (PB‐AKI) in critically ill patients has been reported frequently, but B (PB) is mainly cleared through non‐renal pathways, and the reasons of PB‐AKI remain unclear. The aim this study was to investigate relationship between serum concentration PB PB‐AKI. We conducted a prospective cohort an intensive care unit May 2019 July 2021. Over period, 52 were included divided into AKI group ( n = 26) non‐AKI 26). loading dose...
Abstract Background The elderly with severe infection increased dramatically in intensive care unit (ICU). Proper antimicrobial therapy help improve the prognosis. Linezolid, as an drug, is commonly utilized to treat patients infected methicillin-resistant S. aureus and vancomycin-resistant enterococci. Clinical evidence suggests prone linezolid overexposure. Here, we describe results of three years’ adjustment experiences according therapeutic drug monitoring (TDM), especially oldest old....
To describe the pharmacokinetics/pharmacodynamics (PK/PD) of a 2 h infusion ceftazidime-avibactam (CAZ-AVI) in critically ill patients with augmented renal clearance (ARC). A retrospective review all ARC who were treated CAZ-AVI between August 2020 and May 2023 was conducted. Patients whose 12-h creatinine prior to treatment steady-state concentration (Css) both monitored enrolled. The free fraction (fCss) calculated from Css. joint PK/PD targets considered optimal when Css/minimum...
Exercise is believed to have significant cognitive benefits. Although an array of experimental paradigms been employed test the effects on exercising individuals, mechanism as how exercise induces benefits in brain remains unclear. This study explores effect dynamic neural network processing with classic Go/NoGo task regular exercisers. We used functional magnetic resonance imaging analyze activation areas involved executive function, especially inhibitory control. Nineteen joggers and...
Visual information may convey different affective valences and induce our brain into perceptions. Many studies have found that unpleasant stimuli could produce stronger emotional effects than pleasant could. Although there has been a notion triangle is perceived as negative circle positive, no systematic study to map the degrees of valence shapes with Here, we employed four (ellipse, triangle, line-drawn happy angry faces) investigate behavior electrophysiological responses, in order...