A5037834729- Polyamine Metabolism and Applications
- Amino Acid Enzymes and Metabolism
- FOXO transcription factor regulation
- melanin and skin pigmentation
- Biotin and Related Studies
- Synthesis of Organic Compounds
- Biochemical Analysis and Sensing Techniques
- Renal and related cancers
- Skin Protection and Aging
- Nuclear Receptors and Signaling
- Biochemical Acid Research Studies
- Colorectal Cancer Treatments and Studies
- Retinoids in leukemia and cellular processes
- Synthesis and biological activity
- NF-κB Signaling Pathways
- Circular RNAs in diseases
- Genomics, phytochemicals, and oxidative stress
- Bioactive Compounds and Antitumor Agents
- Metabolism and Genetic Disorders
- Cancer Mechanisms and Therapy
- Microbial Metabolism and Applications
- GABA and Rice Research
- Bioactive natural compounds
- Cancer Treatment and Pharmacology
- Cancer Research and Treatments
Kwangju Women's University
2020-2024
Hormel (United States)
2010-2023
University of Minnesota
2015-2023
Chungbuk National University
2008-2019
Pfizer (South Korea)
2013
Chungnam National University
2010-2012
Yeungnam University
2010
Myeloid differentiation 2 (MD-2) recognizes endotoxin lipopolysaccharide (LPS), which is required for Toll-like receptor 4 (TLR4) activity. MD-2 represents a more attractive therapeutic target than TLR4 intervention in severe inflammatory disorders due to microbial infection. Here, we suggest as molecular of nonlipid chalcone the inhibition LPS-induced cellular inflammation. A derivative, 2′,4-dihydroxy-6′-isopentyloxychalcone (JSH) competitively displaced LPS from MD-2, and was fitted into...
Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis that associated with cell growth and tumor formation. Existing catalytic inhibitors ODC have lacked efficacy clinical testing or displayed unacceptable toxicity. In this study, we report identification an effective nontoxic allosteric inhibitor ODC. Using computer docking simulation vitro assay, identified herbacetin, natural compound found flax other plants, as novel inhibitor. Mechanistic...
Benzoxathiole derivatives have been used in the treatment of acne and shown cytostatic, antipsoriatic, antibacterial properties. However, little is known about molecular basis for these pharmacological properties, although nuclear factor (NF)-kappaB activation closely linked to inflammation cell proliferation. Here, we demonstrate that novel small-molecule benzoxathiole 6,6-dimethyl-2-(phenylimino)-6,7-dihydro-5H-benzo-[1,3]oxathiol-4-one (BOT-64) inhibits NF-kappaB with an IC(50) value 1...
Abstract Cumulative exposure to solar ultraviolet (SUV) irradiation is regarded as the major etiologic factor in development of skin cancer. The activation MAPK cascades occurs rapidly and vital regulation SUV-induced cellular responses. T-LAK cell–originated protein kinase (TOPK), an upstream activator MAPKs, heavily involved inflammation, DNA damage, tumor development. However, chemopreventive therapeutic effects specific TOPK inhibitors cancer have not yet been elucidated. In current...
Herbacetin is a flavonol compound that found in plants such as flaxseed and ramose scouring rush herb, it possesses strong antioxidant capacity, exerts anticancer effects on colon breast cancer. However, the effect of herbacetin skin cancer has not been investigated. Herein, we identified dual V-akt murine thymoma viral oncogene homolog (AKT) ornithine decarboxylase (ODC) inhibitor, illustrated its vitro vivo against cutaneous squamous cell carcinoma (SCC) melanoma growth. To identify direct...
Background and Purpose cAMP as a second messenger stimulates expression of microphthalmia‐associated transcription factor ( MITF ) or the tyrosinase gene in UVB ‐induced skin pigmentation. Diphenylmethylene hydrazinecarbothioamide QNT 3‐80) inhibits α‐melanocyte‐stimulating hormone (α‐ MSH )‐induced melanin production B 16 murine melanoma cells but its molecular basis remains to be defined. Here, we investigated mechanism underlying amelioration hyperpigmentation by 3‐80. Experimental...
Abstract To explore the function of ornithine decarboxylase in esophageal squamous cell carcinoma progression and test effectiveness anti-ornithine therapy for carcinoma. In this study, we examined expression pattern lines tissues using immunohistochemistry Western blot analysis. Then investigated ESCC cells by shRNA an irreversible inhibitor decarboxylase, difluoromethylornithine. gather more supporting pre-clinical data, a human patient-derived xenograft mouse model (C.B-17 severe combined...
Proper repair of damaged DNA is critical for the maintenance genome stability. A complex composed Integrator subunit 3 (Ints3), single-stranded DNA-binding protein 1 (SSB1), and SSB-interacting (SSBIP1) required efficient homologous recombination-dependent double-strand breaks (DSBs) ataxia-telangiectasia mutated (ATM)-dependent signaling pathways. It known that in this Ints3 N-terminal domain scaffolds SSB1 SSBIP1. However, molecular basis function C-terminal remains unclear. Here, we...
Abstract The biological functions of the p53-related protein kinase (PRPK) remain unclear. We have previously demonstrated that PRPK is phosphorylated by T-LAK cell-originated (TOPK) and (p-PRPK) promotes colon cancer metastasis. Here, we analyzed adenocarcinomas from 87 patients found higher expression levels p-PRPK were associated with later stages metastatic dissemination (stage III IV) as compared earlier (stages I II). Indeed, in versus malignant human adenocarcinomas. Knocking down...