A5033067883- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Amino Acid Enzymes and Metabolism
- Inflammation biomarkers and pathways
- Retinal Development and Disorders
- Bipolar Disorder and Treatment
- Neonatal and Maternal Infections
- Blood disorders and treatments
- Mental Health Research Topics
- GABA and Rice Research
- Diet and metabolism studies
- NF-κB Signaling Pathways
- Chemical Synthesis and Analysis
- Biochemical Acid Research Studies
- Treatment of Major Depression
- Adsorption and biosorption for pollutant removal
- Schizophrenia research and treatment
- Electrolyte and hormonal disorders
- Biochemical and Molecular Research
- Epigenetics and DNA Methylation
- Retinal and Optic Conditions
- Ion channel regulation and function
- Prenatal Substance Exposure Effects
- Smoking Behavior and Cessation
- ATP Synthase and ATPases Research
University of Iowa
2004-2024
Assam Down Town University
2022
GRB2 is an adaptor protein required for facilitating cytoplasmic signaling complexes from a wide array of binding partners. has been reported to exist in either monomeric or dimeric state crystal and solution. dimers are formed by the exchange segments between domains, otherwise known as "domain-swapping". Swapping described SH2 C-terminal SH3 domains full-length structure (SH2/C-SH3 domain-swapped dimer), well α-helixes isolated (SH2/SH2 dimer). Interestingly, SH2/SH2 domain-swapping not...
This study was undertaken to identify the clinical and pathoanatomical correlates of irritability in patients with closed head injuries. A consecutive series 66 assessed hospital at 3, 6, 9, 12-month follow-ups. Patients fulfilling criteria for were divided into 2 groups based on immediate or delayed onset their compared without background characteristics, impairment variables, lesion characteristics. There 12 (18.2%) acute 10 (15.1%) irritability. Acute had a higher frequency left cortical...
Triggering receptor expressed on myeloid cells-1 (TREM-1) is critical for inflammatory signal amplification. Humans have two forms of TREM-1: a membrane receptor, associated with the adaptor DAP12, and soluble detected at times infection. The isoform acts synergistically TLR pathway to promote cytokine secretion neutrophil migration, whereas functions as counterregulatory molecule. In multiple models sepsis, exogenous administration TREM-1 attenuates inflammation markedly improves survival....
Neutrophil migration across tissue barriers to the site of injury involves integration complex danger signals and is critical for host survival. Numerous studies demonstrate that these environmental fundamentally alter responses extravasated or "primed" neutrophils. Triggering receptor expressed on myeloid cells 1 (TREM-1) plays a central role in modulating inflammatory signaling neutrophil into alveolar airspace. Using genetic approach, we examined TREM-1 function. response chemoattractants...
Abstract Asthma affects 25 million Americans, and recent advances in treatment are effective for only a portion of severe asthma patients. TREM-1, an innate receptor that canonically amplifies inflammatory signaling neutrophils monocytes, plays central role regulating lung inflammation. It is unknown how TREM-1 contributes to allergic pathology. Utilizing murine model asthma, flow cytometry revealed TREM-1+ eosinophils the tissue airway during expression was restricted recruited,...
Proper repair of damaged DNA is critical for the maintenance genome stability. A complex composed Integrator subunit 3 (Ints3), single-stranded DNA-binding protein 1 (SSB1), and SSB-interacting (SSBIP1) required efficient homologous recombination-dependent double-strand breaks (DSBs) ataxia-telangiectasia mutated (ATM)-dependent signaling pathways. It known that in this Ints3 N-terminal domain scaffolds SSB1 SSBIP1. However, molecular basis function C-terminal remains unclear. Here, we...
Abstract Inflammatory agents, microbial products, or stromal factors pre-activate prime neutrophils to respond activating stimuli in a rapid and aggressive manner. Primed exhibit enhanced chemotaxis, phagocytosis, respiratory burst when stimulated by secondary stimuli. We previously reported that Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) mediates neutrophil effector functions such as increased superoxide generation, transepithelial migration, chemotaxis. However, it is...
The capacity to remove brilliant green from aqueous solutions through biosorption using the Michelia champaca leaf powder (MCLP), was examined in batch experiments. Almost 99.00% of has been removed 10 mg L-1 solution and 93.22% 50 for 0.8 g biosorbent. (MCLP) independent on pH solution. For that reason all adsorption experiments were done without adjusting value. Langmuir monolayer sorption capacity, qm decreases 200 55.56 g-1 (109.63 g-1, mean) with increase MCLP amount 0.2-1.0 L-1....