A5064169551- Food Quality and Safety Studies
- Phytochemicals and Antioxidant Activities
- Pharmacological Effects of Natural Compounds
- Neuroscience and Neuropharmacology Research
- Pesticide Exposure and Toxicity
- Helicobacter pylori-related gastroenterology studies
- Ginseng Biological Effects and Applications
- Marine and coastal ecosystems
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Mesenchymal stem cell research
- Marine Biology and Ecology Research
- Healthcare and Venom Research
- Neurological Disease Mechanisms and Treatments
- Marine and coastal plant biology
- Oceanographic and Atmospheric Processes
- Alzheimer's disease research and treatments
- Ziziphus Jujuba Studies and Applications
- Corneal Surgery and Treatments
- Marine and Coastal Research
- Cholinesterase and Neurodegenerative Diseases
- Phytoestrogen effects and research
- Chemotherapy-induced organ toxicity mitigation
Chungbuk National University
2015-2024
Sungkyunkwan University
2005-2024
Korea Institute of Ocean Science and Technology
2013-2023
Korea National University of Education
2023
Seoul National University Bundang Hospital
2015-2019
Ajou University
2001-2019
Korea Institute of Toxicology
2008-2019
Samsung Medical Center
2019
Asan Medical Center
2019
University of Ulsan
2019
Contrasting magnetic properties were obtained from bulk Mn-doped ZnO synthesized under different processing conditions. While a ferrimagnetic phase transition was observable in Zn0.95Mn0.05O sample processed at 1170 K, no such found for with the same composition 1370 K. The detailed magnetic, structural, and spectroscopic studies of these two samples have revealed that former is attributable to secondary phase, (Mn,Zn)Mn2O4, system. For latter higher temperature, detected major feature...
Mesenchymal stem cells (MSCs) promote functional recoveries in pathological experimental models of central nervous system (CNS) and are currently being tested clinical trials for neurological disorders, but preventive mechanisms placenta-derived MSCs (PD-MSCs) Alzheimer's disease poorly understood. Herein, we investigated the inhibitory effect PD-MSCs on neuronal cell death memory impairment Aβ1-42-infused mice. After intracerebroventrical (ICV) infusion Aβ1-42 14 days, cognitive function...
This paper provides a comprehensive analysis of recent advancements in additive manufacturing, transformative approach to industrial production that allows for the layer-by-layer construction complex parts directly from digital models. Focusing specifically on Directed Energy Deposition, it begins by clarifying fundamental principles metal manufacturing as defined International Organization Standardization and American Society Testing Materials standards, with an emphasis laser- powder-based...
Salt sensitivity of antimicrobial peptides poses a major obstacle in their development as novel antibiotics. Here we report the use helix-capping motifs to confer salt resistance upon helical peptides. The content template peptide [RLLR]5 was almost completely destroyed at concentrations over 200 mm NaCl, leading 8–32-fold decrease activity. However, introduction helix termini resulted structurally stable peptide, which retained membrane-permeabilizing and activities exposure salt....
The anti-atherogenic effects of spirulina (Spirulina platensis) were investigated in the New Zealand White (NZW) rabbit model. animal had hypercholesterolemia induced by being fed a high cholesterol diet (HCD) containing 0.5% for 4 wk, and then HCD supplemented with 1 or 5% (SP1 SP5) an additional 8 wk. Spirulina supplementation lowered intimal surface aorta 32.2 to 48.3%, compared HCD. Serum triglyceride (TG) total (TC) significantly reduced SP groups. After serum low density lipoprotein...
Alzheimer disease (AD) is a progressive neurodegenerative disease, which characterized by loss of memory and cognitive function. In AD patients dysfunction the cholinergic system main cause disorders, decreased activity choline acetyltransferase (ChAT), an enzyme responsible for acetylcholine (ACh) synthesis, observed. present study we investigated if brain transplantation human neural stem cells (NSCs) genetically modified to encode ChAT gene improves function kainic acid (KA)-induced...
Glaucoma is one of the most devastating eye diseases, since disease can develop into blindness and no effective therapeutics are available. Although exact mechanisms causes glaucoma unknown, increased intraocular pressure (IOP) has been demonstrated to be an important risk factor. Exosomes lipid nanoparticles secreted from functional cells, including stem have found contain diverse molecules that control body function, inhibit inflammation, protect regenerate restore damaged tissues. In...
Considering the importance of inflammation and apoptosis in neurodegenerative conditions, potential suppressive effects Rg3, a by-product obtained during steaming red ginseng, may indicate that Rg3 could provide beneficial therapeutic approach to treating or preventing disease. We investigated effect on Abeta42-mediated microglial activation inflammation-mediated neurotoxicity murine BV-2 Neuro-2a neuroblastoma cells, respectively. effectively reduced inflammatory cytokine expression...
The effects of nattokinase on the in vitro platelet aggregation and vivo thrombosis were investigated comparison with aspirin. Rabbit platelet-rich plasma was incubated inducers collagen thrombin, rate analyzed. Nattokinase significantly inhibited both collagen- thrombin-induced aggregations. also reduced thromboxane B2 formation from collagen-activated platelets a concentration-dependent manner. Rats orally administered for 1 week, their carotid arteries exposed. Arterial induced by...
Although tissue-type plasminogen activator was approved by the FDA for early reperfusion of occluded vessels, there is a need an effective neuroprotective drug stroke patients. In this study, we established tumor susceptibility gene (TSG)101-overexpressing human neural stem cells (F3.TSG) and investigated whether they showed enhanced secretion exosomes treatment with during alleviated ischemia-reperfusion-mediated brain damage. F3.TSG secreted higher amounts than parental F3 cells. N2A...
Anti-inflammatory effects of an ethanol extract Angelica gigas (EAG; 50, 160, or 500 mg/kg) were investigated in a carrageenan-induced air pouch inflammation model. Injection 1 ml carrageenan (1%) into mouse pouches markedly increased the exudate volume and albumin concentration, which significantly attenuated by oral pretreatment with EAG. EAG also reduced infiltrations neutrophils, monocytes, lymphocytes, but did not influence eosinophils basophils. Carrageenan dramatically levels tumor...
The anti-inflammatory effects of fuciodan and Cistanche tubulosa (CT) extract were investigated in vitro macrophage culture system vivo carrageenan-induced air pouch inflammation model. CT inhibited nitric oxide production from activated RAW 264.7 cells, while fucoidan was inactive. In model, vascular exudation increased prostaglandin E2 concentrations the exudates synergistically suppressed by co-administration or extract. Moreover, tissue substantially attenuated combinational therapy....
Low-molecular-weight secondary metabolites from plants play an important role in reproductive processes and the defense against environmental stresses or pathogens. In present study, we isolated various volatiles phenolic compounds white Rosa rugosa flowers, evaluated pharmaceutical activities of these natural products addition to their ability increase survival response stress pathogen invasion. The DPPH hydroxyl radical-mediated oxidation assay revealed that rose flower extract (WRFE)...
This study was conducted to investigate the potential effects of diallyl disulfide (DADS) on carbon tetrachloride (CCl4)-induced acute hepatotoxicity and determine molecular mechanisms protection offered by DADS in rats. administered orally at 50 100 mg/kg/day once daily for 5 consecutive days prior CCl4 administration. The single oral dose (2 mL/kg) caused a significant elevation serum aspartate alanine aminotransferase activities, which decreased upon pretreatment with DADS....