A5100624051- Immune Cell Function and Interaction
- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- T-cell and B-cell Immunology
- Colorectal Cancer Surgical Treatments
- Nanoplatforms for cancer theranostics
- Head and Neck Surgical Oncology
- Immune Response and Inflammation
- Reproductive System and Pregnancy
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Invertebrate Immune Response Mechanisms
- Cancer and Skin Lesions
- Colorectal and Anal Carcinomas
- Cytokine Signaling Pathways and Interactions
- Cancer Cells and Metastasis
- IL-33, ST2, and ILC Pathways
- Colorectal Cancer Treatments and Studies
- Advanced Radiotherapy Techniques
- Nonmelanoma Skin Cancer Studies
- Genetic and rare skin diseases.
- Immune cells in cancer
- Aquaculture disease management and microbiota
- Phagocytosis and Immune Regulation
- Management of metastatic bone disease
Yonsei University
2013-2024
Wonju Severance Christian Hospital
2023
CHA University
2018-2021
Kyungpook National University Hospital
2021
CHA Bundang Medical Center
2018-2020
Korea Research Institute of Bioscience and Biotechnology
2008-2019
Sunchon National University
2019
Yonsei University Health System
2015
Eulji University
2010-2011
Primary Source
2011
Buforin II is a 21-aa potent antimicrobial peptide that forms, in hydrophobic medium, an amphipathic structure consisting of N-terminal random coil region (residues 1–4), extended helical 5–10), hinge (residue 11), and C-terminal regular α-helical 12–21). To elucidate the structural features buforin are required for its activity, we synthesized series N- C-terminally truncated or amino acid-substituted synthetic analogs examined their activity mechanism action. Deletion increased...
The activation of spinal cord glial cells has been implicated in the development neuropathic pain upon peripheral nerve injury. molecular mechanisms underlying cell activation, however, have not clearly elucidated. In this study, we found that damaged sensory neurons induce expression tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and inducible nitric-oxide synthase genes cells, which is pain. Studies using primary isolated from toll-like receptor 2 knock-out mice indicate...
In response to epidermal injury, Parasilurus asotus , a catfish, secreted strong antimicrobial peptide into the epithelial mucosal layer. The molecular mass of peptide, named parasin I, was 2000.4 Da, as determined by matrix‐associated laser desorption ionization spectrometry. complete amino acid sequence which automated Edman degradation, Lys‐Gly‐Arg‐Gly‐Lys‐Gln‐Gly‐Gly‐Lys‐Val‐Arg‐Ala‐Lys‐Ala‐Lys‐Thr‐Arg‐Ser‐Ser. Eighteen 19 residues in I were identical N‐terminal buforin 39‐residue...
Natural killer (NK) cells play important roles in immune surveillance. However, the tumor microenvironment suppresses NK cell function and allows cancer to evade detection. In this study, we investigated whether thyroid has effect on cells. We found that prostaglandin (PG) E2 produced by suppressed cytolytic activity of inhibiting expression natural cytotoxicity receptors NKp44 NKp30 death receptor necrosis factor-related apoptosis-inducing ligand. PGE2 cyclooxygenase-2 were highly expressed...
Parasin I is a potent 19-residue antimicrobial peptide isolated from the skin mucus of wounded catfish (Parasilurus asotus). Here we describe mechanism parasin production histone H2A in mucosa on epidermal injury. Cathepsin D found to exist as an inactive proenzyme (procathepsin D), and metalloprotease, induced injury, cleaves procathepsin generate active cathepsin D. This activated form then Ser19-Arg20 bond produce I. Immunohistochemical analysis reveals that unacetylated H2A, precursor I,...
Salt sensitivity of antimicrobial peptides poses a major obstacle in their development as novel antibiotics. Here we report the use helix-capping motifs to confer salt resistance upon helical peptides. The content template peptide [RLLR]5 was almost completely destroyed at concentrations over 200 mm NaCl, leading 8–32-fold decrease activity. However, introduction helix termini resulted structurally stable peptide, which retained membrane-permeabilizing and activities exposure salt....
Abstract Microbial colonization and infection of placental tissues often lead to adverse pregnancy outcomes such as preterm birth, a leading cause neonatal morbidity mortality. The fetal membranes the placenta, physical active barrier microbial invasion, encapsulate fetus secure its intrauterine environment. To examine innate defense system human antimicrobial peptides were isolated from placenta characterized biochemically. Two salt-resistant host proteins purified homogeneity using...
Natural killer (NK) cells are key players in the immune system. They use receptors on their cell surface to identify target cells. However, escape being killed by system, cancer such as thyroid cells, various methods suppress function of NK Thus, this study aims elucidate how downregulate a co-culture We found that cytotoxicity and inhibit expression activating receptors, NKG2D NKp46, regulating indoleamine 2,3-dioxygenase (IDO). Also, produce kynurenine using IDO, which causes dysfunction....
The purpose of this study is to compare the treatment outcomes for locally advanced resectable hypopharyngeal cancer between organ-preserving chemoradiotherapy (CRT) and surgery followed by radiotherapy (SRT). We reviewed 91 patients with stage III/IV squamous cell carcinoma treated (RT). In CRT group (n=34), 18 were concurrent 16 induction chemotherapy plus CRT. SRT (n=57), six total laryngopharyngectomy, 34 laryngectomy (TL) partial pharyngectomy (PP), 17 PP, which adjuvant (n=41) or...
Hypoxia can impair the therapeutic efficacy of radiotherapy (RT). Therefore, a new strategy is necessary for enhancing response to RT. In this study, we investigated whether combination nanoparticles and RT effective in eliminating radioresistance hypoxic tumors.Gold (GNPs) consisting silica core with gold shell were used. CT26 colon cancer mouse model was developed study GNPs reduced hypoxia-induced radioresistance. inducible factor-1α (HIF-1α) used as hypoxia marker. The...
A 19-residue antimicrobial peptide parasin I is generated from histone H2A in the skin mucus of catfish by action cathepsin D activated a procathepsin D-processing enzyme induced upon epidermal injury. Here we report isolation and characterization wounded catfish. Sequence analysis cDNA identified purified as matrix metalloproteinase 2 (MMP 2). By acting convertase injury, MMP involved regulation production mucosa.
Abstract NK cells are capable of killing virus-infected or tumor and producing IFN-γ. Resting cells, however, have only minimal cytolytic activity secrete a low level The cytokine IL-15 can promote the expression effector functions by resting cells. In this study, we demonstrate that suppressor signaling 2 (SOCS2) has novel role in IL-15–primed human cell function. SOCS2 was upregulated following stimulation with IL-15. During IL-15–mediated priming, interacted phosphorylated proline-rich...
<h3>Objectives</h3> To clarify the relationships between sleep-wake cycle and cerebral β-amyloid (Aβ) deposition in cognitively normal (CN) older adults, focusing primarily on moderating effects of <i>APOE</i> ε4 allele. <h3>Methods</h3> The present study included 133 CN adults who participated Korean Brain Aging Study for Early Diagnosis & Prediction Alzheimer9s Disease cohort. All participants underwent [<sup>11</sup>C] Pittsburgh compound B-PET imaging to quantify Aβ brain blood...
Pseudomonas aeruginosa (PA) is an opportunistic pathogen that causes the relapse of illness in immunocompromised patients, leading to prolonged hospitalization, increased medical expense, and death. In this report, we show PA invades natural killer (NK) cells induces phagocytosis-induced cell death (PICD) lymphocytes. vivo tumor metastasis was augmented by infection, with a significant reduction NK number. Adoptive transfer mitigated PA-induced metastasis. Internalization into observed...
Purpose We reviewed treatment outcomes and prognostic factors for patients with salivary ductal carcinoma (SDC) treated surgery postoperative radiotherapy from 2005 to 2012. Materials Methods A total of 16 were identified 15 eligible included in analysis. Median age was 61 years (range, 40 71 years) 12 (80%) men. Twelve had a tumor the parotid gland, 9 (60%) T3 or T4 disease, positive nodal disease. All underwent radiotherapy. Postoperative delivered using 3-dimensional conformal...
Tubular apocrine adenoma (TAA) is a very rare sweat gland tumor.TAA and syringocystadenoma papilliferum (SCAP) rarely develop together in nevus sebaceus (NS).Herein, we report on 40-year-old Korean woman with TAA associated SCAP that developed NS located the scalp.(Ann Dermatol 22(3) 319∼322, 2010) -
Colon organoids (colonoids) are known to be similar colon tissue in structure and function, which makes them useful the treatment of intestinal de-epithelialized disease. Matrigel, is used as a transplantation scaffold for colonoids, cannot clinical applications because its undefined composition tumorigenicity. This study identifies clinically available scaffolds that effective colonoid damaged mucosa. The crypt was isolated cultured from C57BL/6-Tg[CAG enhanced green fluorescent protein...
Abstract Introduction Evidence‐based guidelines recommend hypofractionated palliative radiotherapy (PRT); nonetheless, many patients receive prolonged course of PRT. To identify with limited benefits from PRT in end‐of‐life care, we evaluated the pattern at an Asian institution and factors associated 30‐day mortality after (30dM). Methods We retrospectively reviewed 228 who died Yonsei Wonju Severance Christian hospital between October 2014 March 2022. The associations clinical survival were...
Upper tract urothelial carcinoma (UTUC) is rare and the treatment for recurrent or metastatic UTUC unclear. We evaluated outcomes of salvage palliative radiotherapy (RT) prognostic factors in patients find implications RT.Between August 2006 February 2021, 174 (median age, 68 years; range, 37-90) underwent RT. Disease status at RT included initially diagnosed advanced disease (n = 8, 4.6%), local recurrence only 56, 32.2%), distant metastasis 59, 33.9%), 51, 29.3%). The primary tumor...