A5102879546- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Diverticular Disease and Complications
- Colorectal Cancer Treatments and Studies
- Appendicitis Diagnosis and Management
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Intraperitoneal and Appendiceal Malignancies
- Minimally Invasive Surgical Techniques
- Tissue Engineering and Regenerative Medicine
- COVID-19 and healthcare impacts
- Mesenchymal stem cell research
- Genetic factors in colorectal cancer
- Congenital Diaphragmatic Hernia Studies
- Enhanced Recovery After Surgery
- Inflammatory Biomarkers in Disease Prognosis
- Pelvic and Acetabular Injuries
- Hernia repair and management
- interferon and immune responses
- Effects of Radiation Exposure
- Blood Coagulation and Thrombosis Mechanisms
- Global Healthcare and Medical Tourism
- Breast Implant and Reconstruction
- Layered Double Hydroxides Synthesis and Applications
- Cancer Research and Treatments
Gangnam Severance Hospital
2023-2025
Yonsei University
2014-2025
CHA Bundang Medical Center
2016-2024
Severance Hospital
2015-2023
CHA University
2016-2022
American Society of Anesthesiologists
2021
Creative Commons
2015-2021
Versus Arthritis
2021
Weatherford College
2021
Hôpital Universitaire International Cheikh Khalifa
2015
Peritoneal carcinomatosis is a fatal clinical presentation of colon cancer, characterized by unresponsiveness to conventional anticancer therapies, including immune checkpoint inhibitors. Here, we elucidated the immune-evasion mechanisms during peritoneal cancer and developed novel immunotherapy activating stimulator interferon genes (STING) pathway. We generated syngeneic model cancer. Mice were intraperitoneally treated with either STING agonist (MIW815, also known as ADU-S100) or PD-1...
Background: Stimulator of Interferon Genes (STING) is an innate immune sensor for cytosolic DNA.STING signaling activation indispensable type I interferon response and the anti-cancer by CD8 + T cells.The aim this study was to characterize intratumoral STING expression pattern its clinical implication in colorectal cancer (CRC).Methods: We analyzed 225 CRC patients who underwent surgical resection.Clinicopathological variables survival outcomes were according levels.Mice with syngeneic MC38...
Abstract Background A significant unmet need in inflammatory bowel disease is the lack of anti-fibrotic agents targeting intestinal fibrosis. This study aimed to investigate anti-fibrogenic properties and mechanisms conditioned medium (CM) from human umbilical cord/placenta-derived mesenchymal stem cells (UC/PL-MSC-CM) a murine fibrosis model primary myofibroblasts (HIMFs). Methods UC/PL-MSC-CM was concentrated 15-fold using 3 kDa cut-off filter. C57BL/6 mice aged 7 weeks old were randomly...
Peritoneal carcinomatosis (PC) is a common and devastating manifestation of colon cancer refractory to conventional anticancer therapeutics. During the peritoneal dissemination cancer, immunity nullified by various mechanisms immune evasion. Here, we employed armed oncolytic vaccinia virus mJX-594 (JX) rejuvenate antitumor responses in treatment PC.PC model MC38 was generated intraperitoneally treated with JX and/or anti-programmed cell death protein 1 (PD-1) antibody. The tumor burden,...
Background DaVinci Single-Port (SP) robotic surgery offers several benefits compared to traditional multiport laparoscopic or surgeries. One of the main advantages is that it allows for a minimally invasive approach, resulting in single, smaller incision and reduced trauma patient’s body leading less postoperative pain, faster recovery, risk complications. The cosmesis single port with minimal visible scarring also an attractive aspect patients; however, many surgeons use additional energy...
Abstract Background The lack of anti-fibrotic agents targeting intestinal fibrosis is a large unmet need in inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis. Previous studies have found that perinatal tissue (umbilical cord, UC; placenta, PL)-derived mesenchymal stem cells (MSCs) reduce several organs. However, their effects on human are poorly understood. This study investigated the anti-fibrogenic properties mechanisms MSCs derived from UC PL (UC/PL-MSCs)...
The spread of COVID-19 has led to numerous hospitals prioritizing case management and delays in diagnosis treatment. Consequently, many cancer patients have developed life-threatening complications during the pandemic. aim this study was investigate impact pandemic on colorectal (CRC), including its clinical pathologic characteristics. This multicenter cohort performed at six institutions Korea included a total 3871 with CRC treated between March 2019 February 2021. After exclusion 211 who...
Preoperative chemoradiotherapy (CRT) is the standard of care for patients with stage II and III rectal cancer. This strategy leads to pathologic complete response (pCR) in a significant number patients. Factors predictive pCR are currently being extensively investigated. The aim this study was analyze clinical factors that might be pCR. retrospective analysis cancer from January 2004 through December 2012. A total 332 middle low (≤10 cm) who received CRT underwent curative mesorectal...
Although microsatellite instability-high (MSI-H) colorectal cancers (CRCs) have been shown to exhibit a distinct phenotype, the clinical value of MSI-low (MSI-L) in CRC remains unclear. We designed this study examine clinicopathologic characteristics and oncologic implications associated with MSI-L CRCs. retrospectively reviewed data patients from 3 tertiary referral hospitals Korea, who underwent surgical resection between January 2003 December 2009 had available MSI testing results. was...
Background: DaVinci® single-port (SP) robotic surgery offers several benefits compared to traditional multiport laparoscopic or surgeries. One of the main advantages is that it allows for a minimally invasive approach, resulting in single, smaller incision and reduced trauma patient's body, leading less postoperative pain, faster recovery, risk complications. The cosmesis single port with minimal visible scarring also an attractive aspect patients; however, many surgeons use additional...
Laparoscopic resection for transverse colon cancer is a technically challenging procedure that has been excluded from various large randomized controlled trials of which the long-term outcomes still need to be verified. The purpose this study was evaluate oncologic patients undergoing laparoscopic colectomy (LAC) or open (OC).This retrospective review included with who received between January 2006 and December 2010. Short-term five-year were compared these groups.A total 131 analyzed in...
Purpose Previous studies have demonstrated the prognostic impact of nutritional index (PNI), a proposed indicator immunonutritional statuses surgical patients, on patients with various gastrointestinal cancers. Although PNI colorectal cancer has been well established, its value not studied in treated preoperative chemoradiation (pCRT). This study aimed to evaluate receiving pCRT for locally advanced rectal (LARC). Methods Patients LARC who underwent curative followed by resection were...
A minimum of 12 harvested lymph nodes (hLNs) are recommended in colorectal cancer. However, a paucity hLNs is frequently presented after preoperative chemoradiation (pCRT) rectal cancer and the significance this still uncertain. The aim study to analyze impact on long-term oncologic outcomes. total 302 patients with locally advanced who underwent pCRT curative resection between 1989 2009 were reviewed. Patients categorized into 2 groups according number hLNs: <12 versus ≥12 LN. compared...
A granular cell tumor (GCT) is an uncommon mesenchymal lesion that rarely occurs in the colon and rectum. We describe case of 51-year-old man with a 2-cm-sized rectal GCT 10 cm above anal verge was incidentally detected after screening colonoscopy. Preoperative radiologic studies demonstrated suspicious submucosal mass mesorectal fat infiltration, but without circumferential resection margin threatening, extramural vessel invasion, regional lymph-node enlargement. The resected by using...
Inguinal hernia is a common disease treated with diverse methods. Nowadays, laparoscopic totally extraperitoneal approach gaining its validity and shows favorable outcomes. However, single-incision surgery also widening applicable fields as new technique. This study aimed to find whether total inguinal repair (SILTEP) compared conventional (CLTEP).We retrospectively reviewed 120 cases of SILTEP 60 CLTEP in Yonsei University Severance Hospital from January 2012 December 2013. Each group was...
The plasminogen activator inhibitor-1 (PAI-1) is expressed in many cancer cell types and modulates growth, invasion, angiogenesis. present study investigated the association between five PAI-1 gene polymorphisms colorectal (CRC) risk. Five (−844G > A [rs2227631], −675 4G 5G [rs1799889], +43G [rs6092], +9785G [rs2227694], +11053T G [rs7242]) were genotyped using a polymerase chain reaction-restriction fragment length polymorphism assay 459 CRC cases 416 controls. Increased risk was more...
Purpose: To evaluate the Recurrence Score ® of quantitative 12-multigene expression assay and to determine risk groups based on continuous in Korean patients. Method: A total 95 patients with pathological T3N0 tumors mismatch repair-proficient were enrolled. The was used classify (low risk, <30; intermediate 30–40; high ≥41). Results: Fifty-four (56.8%) aged over 70 years. There 49 men (51.6%) 56 cases right-sided colon cancer (58.9%). Eight (8.4%) had well-differentiated tumors, 86 (90.5%)...
Although the feasibility of laparoscopic appendectomy (LA) in complicated appendicitis (CA) has been demonstrated, LA is typically underused CA due to its high conversion rate. However, little known regarding clinical course CA.Between January 2005 and April 2012, 1699 patients older than 16 years underwent an at our institution. Of these, 207 were confirmed have CA, which was defined as operative findings gangrenous or perforated appendix, with without abscess formation. Patients divided...
With the advent of checkpoint inhibitors, it has opened up opportunities for numerous cancer patients. However, as is case with every treatment, complications need to be weighed. Gastrointestinal adverse effects, such diarrhea and colitis are well-known inhibitors. In severe cases, colitis-induced colonic perforation may occur an estimation 1.0% 1.5% in anti-CTLA-4 antibodies. only a handful cases devastating have been reported anti-PD-1 antibodies pembrolizumab nivolumab. We here report...
Abstract Background Malignant transformation of endometriosis in extraovarian sites remains rare. Furthermore, the process is not definitely understood. Case presentation Herein, we report case a 40-year-old premenopausal nulligravida woman who presented with vaginal bleeding and was finally diagnosed cancer originating from synchronous endometrial cancer. A gynecologic examination revealed multiple polypoid mass on posterior fornix. Magnetic Resonance Imaging pelvis showed two masses...