A5066941115- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Colorectal and Anal Carcinomas
- Head and Neck Surgical Oncology
- Salivary Gland Tumors Diagnosis and Treatment
- Tracheal and airway disorders
- Ear and Head Tumors
- Virus-based gene therapy research
- Oral and Maxillofacial Pathology
- Voice and Speech Disorders
- Cancer Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Dysphagia Assessment and Management
- Thyroid and Parathyroid Surgery
- Radiomics and Machine Learning in Medical Imaging
- Cleft Lip and Palate Research
- Lung Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Bone Tumor Diagnosis and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Trauma Management and Diagnosis
- Cancer-related molecular mechanisms research
- Mechanisms of cancer metastasis
- Lung Cancer Treatments and Mutations
Yonsei University
2015-2024
Severance Hospital
2015-2024
Yonsei University Health System
2024
Chungbuk National University Hospital
2022-2023
Gangnam Severance Hospital
2022
Penn State Milton S. Hershey Medical Center
2018
Chungnam National University Hospital
2015
Konyang University
2009
Memorial Sloan Kettering Cancer Center
2001-2005
American College of Surgeons
2005
The prevalence of human papillomavirus (HPV) infection is high in the oropharyngeal mucosal regions, which tonsil most commonly affected. There may be a link between HPV and pathogenesis tonsillar cancer (TC), because common anatomical characteristics cervical cancer. We aimed to clarify whether directly affects oncogenesis biologic behavior TC by making comparison prevalence, physical status viral loading numbers, clinicopathologic prognostic factors. To compare HPV-related molecules...
The current trend in managing laryngeal and hypopharyngeal cancer is to perform organ preservation therapy, which improves quality of life decreases treatment-related morbidity. Transoral robotic surgery (TORS) can overcome the limit "line sight" often met classic transoral procedure. We utilized a surgical system evaluate feasibility oncologic safety partial pharyngectomy laryngectomy.TORS was performed by using "da Vinci robot" (Intuitive Surgical, Inc., Sunnyvale, CA). An FK retractor...
We performed transoral robotic surgery (TORS) or conventional via a mandibulotomy approach in patients with tonsillar cancer and prospectively analyzed the oncologic outcomes functional recovery of 3 groups.Between May 2008 October 2011, 57 were enrolled this prospective study.Although there was no significant difference survival rate TORS group (100%) (96.7%), higher margin negativity observed group, especially cases which tumor extends inferiorly. Patients who received procedures showed...
Da Vinci single port (SP) has been recently approved for transoral robotic surgery (TORS). Its characteristics make it particularly feasible laryngeal and hypopharyngeal surgery. We report our experience comparing intra- postoperative outcomes, technical advantages, shortcomings of resections performed with the da SP Si/Xi systems.Retrospective database review.Single academic tertiary care hospital.Subjects included adult patients carcinoma who underwent TORS between 2008 2022. The multiport...
Replication-competent, attenuated herpes simplex viruses (HSV) have been demonstrated to be effective oncolytic agents in a variety of malignant tumors. Cytokine gene transfer has also used as immunomodulatory therapy for cancer. To test the utility combining these two approaches, HSV vectors (NV1034 and NV1042) were designed express murine GM-CSF IL-12 genes, respectively. These cytokine-carrying variants compared with analogous non-cytokine-carrying control virus (NV1023) treatment SCC VII...
Abstract Objectives/Hypothesis: Prophylactic treatment of contralateral N0 neck in early squamous cell carcinoma (SCC) the oral tongue is a controversial issue. The aim this study was to analyze rates occult metastases and their prognostic effects stage I II SCC tongue, compare results elective dissection observation these patients. Study Design: Retrospective review. Methods: We reviewed medical records 54 patients who were treated at Severance Hospital from 1992 2003 had been diagnosed...
Abstract Background and Objectives In oral tongue cancer, the degree of tumor invasion has a significant effect on prognosis. We hypothesized that destruction extracelluar matrix neovascularization are related to infiltration mechanism. By studying tissues early stage cancer patients, we intending clarify invasion‐related factors. Materials Methods To demonstrate process in T‐stage expressions extracellular destruction‐related molecules (MMP‐2, MMP‐9) neovascularization‐related molecule...
Abstract Objectives: It is well established that tonsillar squamous cell carcinomas have a high probability of disseminating to the neck. An ipsilateral neck treatment mandatory during initial stages II IV carcinomas. However, as yet, no consensus exists whether perform elective contralateral management. Materials and Methods: A retrospective analysis 43 N0‐3 cancer patients with clinically negative necks from 1992 2002 was performed. All had dissection. Surgical followed by postoperative...
In transoral robotic surgery (TORS), if an endoscopic arm equipped with two integrated cameras is placed close to a lesion, three-dimensionally magnified view of the operative field can be obtained. More important that operation performed precisely and bimanually using instrument arms move freely within limited working space. We TORS treat several diseases occur in parapharyngeal space (PPS) subsequently analyzed treatment outcomes confirm validity this procedure.Between February 2009 2012,...
The purpose of this study is to compare the treatment outcomes for locally advanced resectable hypopharyngeal cancer between organ-preserving chemoradiotherapy (CRT) and surgery followed by radiotherapy (SRT). We reviewed 91 patients with stage III/IV squamous cell carcinoma treated (RT). In CRT group (n=34), 18 were concurrent 16 induction chemotherapy plus CRT. SRT (n=57), six total laryngopharyngectomy, 34 laryngectomy (TL) partial pharyngectomy (PP), 17 PP, which adjuvant (n=41) or...
Abstract Background We attempted to predict pathological factors and treatment outcomes using machine learning radiomic features extracted from preoperative magnetic resonance imaging (MRI) of oropharyngeal squamous cell carcinoma (OPSCC) patients. Methods The medical records data 155 patients who were diagnosed with OPSCC analyzed retrospectively. Results logistic regression model showed that the area under receiver operating characteristic curve (AUC) was 0.792 in predicting human...
Clinical implications of neoadjuvant immunotherapy in patients with locally advanced but resectable head and neck squamous cell carcinoma (HNSCC) remain largely unexplored.
There are two promising herpes viral-based anticancer strategies: one involves replication-defective viruses to transfer therapeutic transgenes, and the other replication-conditional oncolytic viruses, which selectively infect destroy cancer cells directly. This study examines a novel dual herpesvirus preparation, combines immunostimulatory effects of amplicon-mediated IL2 expression with direct viral-induced oncolysis. The virus G207 was used as helper package simplex (HSV)-amplicon vector...
Conclusions: The oncologic outcome of transoral robotic surgery (TORS) was comparable to radical open surgery. TORS group showed a better functional recovery and quality life (QOL) than the group. Therefore, valid treatment option as minimally invasive for selected patients with hypopharyngeal cancer. Objectives: To affirm rapid improved QOL who underwent TORS, which is surgical technique. Methods: Between April 2008 November 2011, 56 were enrolled in study. During study period, 30 26...
To develop machine learning (ML) models for predicting positive margins in patients undergoing transoral robotic surgery (TORS).Data from 453 with laryngeal, hypopharyngeal, and oropharyngeal squamous cell carcinoma were retrospectively collected at a tertiary referral center to train (n = 316) validate 137) six two-class supervised ML employing 14 variables available pre-operatively.The accuracy of the ranged between 0.67 0.75, while measured AUC 0.68 0.75. The algorithms showed high...
Oncolytic herpesviruses have significant antitumoral effects in animal models when delivered directly to established tumors. Lymphatic metastases are a common occurrence for many tumor types. This study investigates the potential of an attenuated, replication-competent, oncolytic herpes simplex virus (NV1023) both treat primary by direct injection and travel through lymphatic system metastatic within lymph nodes draining from site cancer. Isosulfan blue dye was injected into murine auricles...