A5100430154- HER2/EGFR in Cancer Research
- MicroRNA in disease regulation
- Chemotherapy-induced organ toxicity mitigation
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Kruppel-like factors research
- Cancer-related molecular mechanisms research
- NF-κB Signaling Pathways
- Genomics, phytochemicals, and oxidative stress
- Cell death mechanisms and regulation
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- Effects and risks of endocrine disrupting chemicals
- Heavy Metal Exposure and Toxicity
- RNA and protein synthesis mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Garlic and Onion Studies
- RNA Interference and Gene Delivery
- Ovarian cancer diagnosis and treatment
- HIV Research and Treatment
- Cancer Mechanisms and Therapy
- Pharmacological Effects of Natural Compounds
- Circadian rhythm and melatonin
- HIV/AIDS drug development and treatment
Korea Institute of Toxicology
2016-2025
Yeouido St. Mary's Hospital
2023-2024
Catholic University of Korea
2013-2024
Kyungpook National University
2019-2022
Cheongju University
2020
Daegu-Gyeongbuk Medical Innovation Foundation
2015-2019
Korea University of Science and Technology
2018
Chonnam National University
2010-2016
University of California, San Francisco
2016
University of Pittsburgh
2014
Abstract Purpose: Mechanisms of immune dysregulation associated with advanced tumors are relatively well understood. Much less is known about the role effectors against cancer precursor lesions. Endometrioid and clear-cell ovarian partly derive from endometriosis, a commonly diagnosed chronic inflammatory disease. We performed here comprehensive gene expression analysis pelvic inflammation in endometriosis endometriosis-associated (EAOC). Experimental Design: RNA was extracted 120 paraffin...
Linear peptides derived from the HIV gp41 C-terminus (C-peptides), such as 36-residue Fuzeon, are potent fusion inhibitors. These molecules bind to N-peptide region of and inhibit an intramolecular protein-protein interaction that powers viral host cell membranes. The contains a surface pocket is occupied in post-fusion state by three alpha-helical residues found near C-terminus: Trp628, Trp631, Ile635-the WWI epitope. Here, we describe set beta3-decapeptides (betaWWI-1-4) which epitope...
Analytical chemistry has played a pivotal role in soil science, providing an avenue for advances knowledge and understanding of the transformation, reactivity, occurrence chemical compounds soil. Organic matter, perhaps least known area soil, generally suffered from lack suitable techniques its characterization, but that is changing rapidly as new analytical methods, used primarily biochemistry field, are being applied. This review intended to highlight some routinely advanced studies...
The venom from spiders, scorpions, and sea anemone contain a rich diversity of protein toxins that interact with ion channel voltage sensors. Although atomic structures have been solved for many these toxins, the surfaces are critical interacting sensors poorly defined. Hanatoxin SGTx tarantula inhibit activation Kv channels by each four In this study we set out to identify active surface alanine-scanning characterizing interaction mutant Kv2.1 channel. Examination concentration dependence...
SGTx1 is a peptide toxin isolated from the venom of spider Scodra griseipes that has been shown to inhibit outward K+ currents in rat cerebellar granule neurons. Although its amino acid sequence known be highly (76%) homologous with hanatoxin (HaTx), well-characterized modifier Kv2.1 channel gating, structural and functional characteristics remain largely unknown. Here we describe NMR solution structure SGTx1, mechanism interaction channels, effect on activity once bound. The contains...
The endoplasmic reticulum (ER) provides an environment optimized for oxidative protein folding through the action of Ero1p, which generates disulfide bonds, and Pdi1p, receives bonds from Ero1p transfers them to substrate proteins. Feedback regulation reduction oxidation regulatory within is essential maintaining proper redox balance in ER. In this paper, we show that Pdi1p key regulator activity. Reduced resulted activation by direct bonds. Conversely, upon depletion thiol substrates...
Blocking a BMP signaling pathway may ameliorate neurological defects in patients with fragile X syndrome.
Abstract BACKGROUND: Although the potential risk of carbon nanotubes (CNTs) to humans has recently increased due expanding production and widespread use, adverse effects CNTs on embryo–fetal development have not yet been determined. METHODS: This study investigated multi‐wall (MWCNTs) pregnant dams in rats. MWCNTs were administered rats by gavage at 0, 40, 200, 1,000 mg/kg/day. All subjected Cesarean section day 20 gestation, fetuses examined for any morphological abnormalities. RESULTS:...
Abstract Many systemic therapeutic options for advanced metastatic HER2-positive breast cancer have been approved, including antibody-based therapies, chemotherapies, and tyrosine kinase inhibitors (TKIs). However, brain metastasis acquired resistance are still major unmet medical needs HER2-driven solid cancers. VRN101099 is an orally available HER2 inhibitor with excellent selectivity over other kinases, EGFR. tightly occupies the ATP-binding pocket of forming a covalent bond Cys805,...
Abstract PKMYT1, a serine/threonine kinase, selectively regulates CDK1 during the G2/M phase transition to prevent mitotic entry in presence of DNA damage, whereas WEE1 kinase both and CDK2. Inhibition PKMYT1 forces cancer cells prematurely enter mitosis without repairing thereby leading cell death. Therefore, is an attractive target for synthetic lethality damage-sensitive cells, such as those with hyperactive CCNE1/CDK2 signaling p53 mutations. CCNE1 amplification (Copy number ≥ 6)...
Abstract Metastatic non-small cell lung cancer (NSCLC) harboring activating epidermal growth factor receptor (EGFR) mutations, such as Del19 and L858R, has seen significant therapeutic advancements with the development of effective systemic treatments. However, acquired resistance mutations (e.g., C797S), rare EGFR brain/leptomeningeal metastases (BM/LM) in patients intrinsic or to current standard-of-care (SoC) therapies remain critical unmet medical needs. VRN110755 is a novel inhibitor...
During human immunodeficiency virus entry, gp41 undergoes a series of conformational changes that induce membrane fusion. Immediately prior to fusion, exists in prehairpin intermediate which the N- and C-peptide regions are exposed. Rearrangement this into six-helix bundle composed trimeric coiled coil from N-peptide region (N-trimer) surrounded by three peptides provides driving force for whereas prevention formation inhibits viral entry. Because its central role mediating N-trimer is key...