A5101555106- Acute Myeloid Leukemia Research
- biodegradable polymer synthesis and properties
- Cancer and Skin Lesions
- Microplastics and Plastic Pollution
- Pancreatic function and diabetes
- Garlic and Onion Studies
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Phytochemicals and Antioxidant Activities
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- melanin and skin pigmentation
- Diabetes Treatment and Management
- Microbial Fuel Cells and Bioremediation
- Multiple Myeloma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Dupuytren's Contracture and Treatments
- Oral Health Pathology and Treatment
- Diabetes and associated disorders
- Cholesterol and Lipid Metabolism
- Acute Lymphoblastic Leukemia research
- Contact Dermatitis and Allergies
- Marine and Coastal Research
- Genetic and rare skin diseases.
- Soft tissue tumor case studies
- Advanced biosensing and bioanalysis techniques
Seoul National University
2012-2024
Chonnam National University Hwasun Hospital
2022-2024
Chungbuk National University
2023
Wonkwang University
2023
CHA Bundang Medical Center
2022
CHA University
2022
Chungnam National University
2008-2022
Asan Medical Center
2022
Korea Institute of Science and Technology
2006-2021
University of Ulsan
2021
The anti-atherogenic effects of spirulina (Spirulina platensis) were investigated in the New Zealand White (NZW) rabbit model. animal had hypercholesterolemia induced by being fed a high cholesterol diet (HCD) containing 0.5% for 4 wk, and then HCD supplemented with 1 or 5% (SP1 SP5) an additional 8 wk. Spirulina supplementation lowered intimal surface aorta 32.2 to 48.3%, compared HCD. Serum triglyceride (TG) total (TC) significantly reduced SP groups. After serum low density lipoprotein...
3-Hydroxypropionic acid (3-HP) is an important platform chemical which can be produced biologically from glycerol. Klebsiella pneumoniae ideal biocatalyst for 3-HP because it grow well on glycerol and naturally synthesize the essential coenzyme B12. On other hand, if higher yields titers of are to achieved, sustained regeneration NAD+ under anaerobic conditions, where B12 synthesized sustainably, required. In this study, recombinant K. L17 overexpressing aldehyde dehydrogenase (AldH) was...
Abstract This study aimed to validate the 2022 European LeukemiaNet (ELN) risk stratification for acute myeloid leukemia (AML). A total of 624 newly diagnosed AML patients from 1998 2014 were included in analysis. Genetic profiling was conducted using targeted deep sequencing 45 genes based on recurrent driver mutations. In total, 134 (21.5%) had their classification reassessed according ELN stratification. Among those initially classified as having a favorable 2017 ( n = 218), 31 and 3...
The effect of diet supplemented with red beet (Beta vulgaris L.) leaf on antioxidant status plasma and tissue was investigated in C57BL/6J mice. mice were randomly divided into two groups after one-week acclimation, fed a high fat (20%) cholesterol (1%) without (control group) or 8% freeze-dried (RBL for 4 weeks. In RBL mice, lipid peroxidation determined as 2-thiobarbituric acid-reactive substances (TBARS value) significantly reduced the selected organs (liver, heart, kidney). Levels...
The beneficial effect of Spirulina (Spirulina platensis) on tissue lipid peroxidation and oxidative DNA damage was tested in the hypercholesterolemic New Zealand White rabbit model. After hypercholesterolemia induced by feeding a high cholesterol (0.5%) diet (HCD) for 4 weeks, then HCD supplemented with 1% or 5% (SP1 SP5, respectively) provided an additional 8 weeks. supplementation significantly reduced increased level HCD-fed rabbits, levels recovered to control values. Oxidative stress...
Optimization of the specific affinity cardiac delivery vector could significantly improve efficiency gene/protein delivery, yet no vectors to date have sufficient target specificity for myocardial infarction (MI). In this study, we explored bacterial tropism infarcted myocardium based on our previous observations that certain bacteria are capable targeting hypoxic regions in solid tumors. Out several Escherichia coli or Salmonella typhimurium strains, S. defective synthesis ppGpp (ΔppGpp...
Data on the impact of resistance training insulin in overweight or obese children are inconclusive.Thirty South Korean adolescents (mean age 13.10 years) were divided by sex, and then randomly assigned to one three treatment groups, which diet only (DO), with aerobic exercise (AE), (RT) group. Physiologic metabolic parameters assessed at baseline after 12 weeks modification.Both groups (aerobic resistance) showed significant improvements their area under curve sensitivity index values when...
Rutaecarpine (RUT) is a bioactive alkaloid isolated from the fruit of Evodia rutaecarpa that exerts cellular protective effect. However, its effects on endothelial cells and mechanism action are still unclear. In this study, we demonstrated RUT nitric oxide (NO) synthesis via synthase (eNOS) phosphorylation in underlying molecular mechanisms. treatment promoted NO generation by increasing eNOS phosphorylation. Additionally, induced an increase intracellular Ca2+ concentration...
Extracts from Salvia miltiorrhiza Bunge have been used in traditional Asian medicine to treat coronary heart disease, chronic renal failure, atherosclerosis, myocardial infraction, angina pectoris, ischemia, dysmenorrheal, neurasthenic insomnia, liver fibrosis and cirrhosis. The aim of the study was investigate anti-RANK signal effect combination S.miltiorrhiza (SME) liquefied calcium (LCa) supplement with ovariectomized (OVX-SML) mice, a osteoporosis animal model. Results were compared...
Daily consumption of an antioxidant-rich leafy vegetable mix (LVM) was assessed for beneficial effects on plasma lipid profiles, tissue peroxidation, and oxidative DNA damage in C57BL/6J mice fed a high fat cholesterol diet (20% 1% cholesterol, wt/wt) 4 weeks. The LVM contained beet leaf, angelica, red leaf lettuce, dandelion, green cos lollo rosso, romaine lettuce (12.5%, respectively), scotch kale, kale (6.25%, respectively). (n = 16) were randomly divided into either the control (high...
Korean Type 2 Diabetes Patients have Multiple Adenomatous Polyps Compared to Non-diabetic ControlsWe tested the correlation between diabetes and aggressiveness of colorectal polyps in diabetic patients matched non-diabetic controls.We retrospectively studied 3,505 type (T2DM) without gastrointestinal symptoms who underwent colonoscopy for cancer at Samsung Medical Center, Seoul, Korea from August 1995 2009.We 495 subjects with colon whom were detected by year colonoscopy, age, sex body mass...
The white-rot fungi Ceriporia lacerata is used in bioremediation, such as lignocellulose degradation, nature. Submerged cultures and extracts of C. mycelia (CLM) have been reported to contain various active ingredients, including β-glucan extracellular polysaccharides, exert anti-diabetogenic properties mice cell lines. However, the immunostimulatory effects not yet reported. This study aimed identify immunomodulatory effects, underlying mechanisms thereof, submerged CLM using RAW264.7...
Crizotinib is a clinically approved tyrosine kinase inhibitor for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) harboring EML4-ALK fusion. was originally developed as an MET (HGF receptor), which involved in cascade. However, little known about whether crizotinib inhibits tumor metastasis NSCLC cells. In this study, we found that suppressed TGFβ signaling by blocking Smad phosphorylation ALK/MET/RON/ROS1-independent manner Molecular docking...
We investigated the effect of butanol fraction from methanol extract butterbur (Petasites japonicus Max.) (BMP) on plasma lipid profiles and oxidative damage liver in mice challenged with monosodium l-glutamate (MSG). ICR (6–8 weeks old, male) were fed BMP (0.1% or 0.3%) for 1 week, day 7, MSG (4 mg/g) was administered intraperitoneally to mice. Administration resulted a significant decrease antioxidant biomarkers such as total glutathione level enzyme activities reductase (GR), peroxidase...
Retrospective Cross-sectional Analysis of 19-year-old Men in KoreaObjective personality tests, such as the Minnesota Multiphasic Personality Inventory (MMPI), might be more sensitive to reflect subclinical and statedependent an individual's lifetime, so they are good scales predict psychological distress regarding certain states.The aim this study was identify specific pattern between body mass index (BMI) using objective test.For study, we investigated BMI Korean Military (MPI).A...
Objectives This study aimed to evaluate the prognostic significance of revised European LeukemiaNet (ELN)−2022 risk stratification model for 123 elderly acute myeloid leukemia (AML) patients treated with decitabine chemotherapy.