A5100764706- Thyroid Cancer Diagnosis and Treatment
- Infant Development and Preterm Care
- Sphingolipid Metabolism and Signaling
- Neonatal Health and Biochemistry
- Thyroid and Parathyroid Surgery
- Hematological disorders and diagnostics
- Kruppel-like factors research
- Thyroid Disorders and Treatments
- Endoplasmic Reticulum Stress and Disease
- Neutropenia and Cancer Infections
- Folate and B Vitamins Research
- Natural Antidiabetic Agents Studies
- Antioxidant Activity and Oxidative Stress
- Family and Disability Support Research
- Child Nutrition and Feeding Issues
- Cancer Mechanisms and Therapy
- Porphyrin Metabolism and Disorders
- Phagocytosis and Immune Regulation
- Meningioma and schwannoma management
- Cerebral Venous Sinus Thrombosis
- Ophthalmology and Eye Disorders
- Ethics and Legal Issues in Pediatric Healthcare
- Cholesterol and Lipid Metabolism
- Renal Diseases and Glomerulopathies
- Hippo pathway signaling and YAP/TAZ
Ewha Womans University
2023-2024
Catholic University of Korea
2006-2023
Gachon University
2016-2019
Children's Hospital of Pittsburgh
2018
Seoul St. Mary's Hospital
2012-2017
Konkuk University Medical Center
2008-2016
Center for Cancer and Blood Disorders
2016
Phoenix Children's Hospital
2016
Severance Hospital
2013
Korea Institute of Brain Science
2013
The endoplasmic reticulum (ER) is not only important for protein synthesis and folding but also crucial lipid metabolism. In the current study, we demonstrate an role of ceramide synthases (CerS) in ER stress NAFLD progression. Ceramide sphingolipid metabolism, its acyl chain length determined by a family six CerS mammals. CerS2 generates C22-C24 ceramides, CerS5 or CerS6 produces C16 ceramide. To gain insight into NAFLD, used high-fat diet (HFD)-induced mouse model. Decreased levels...
In this study, we developed novel lung organoid-on-chip models that elucidate differential human tissue response to various strains of respiratory pathogens: Streptococcus pneumoniae and SARS-CoV-2. We show fetal-derived distal epithelial cells are readily expandable in 3D as organoids, thereby providing a highly sustainable source progenitor cells. These organoid progenitors can then be induced produce airway alveolar organoids on microfluidic devices. Upon challenge with pneumoniae,...
The tall cell variant of papillary thyroid carcinoma (TCVPTC) is more aggressive than classic (PTC), but the percentage cells needed to diagnose TCVPTC remains controversial. In addition, little known about clinicopathologic features PTC with (TCF).We retrospectively selected and reviewed presence BRAF mutation in 203 cases PTC, 149 TCF, 95 TCVPTCs, which were defined as PTCs having <10%, 10-50%, ≥50% cells, respectively.TCVPTCs TCF did not vary significantly characteristics such pathologic...
The effect of diet supplemented with red beet (Beta vulgaris L.) leaf on antioxidant status plasma and tissue was investigated in C57BL/6J mice. mice were randomly divided into two groups after one-week acclimation, fed a high fat (20%) cholesterol (1%) without (control group) or 8% freeze-dried (RBL for 4 weeks. In RBL mice, lipid peroxidation determined as 2-thiobarbituric acid-reactive substances (TBARS value) significantly reduced the selected organs (liver, heart, kidney). Levels...
Ongoing characterization of glioma has revealed that Akt signaling plays a crucial role in gliomagenesis. In mouse models, however, alone was not sufficient to induce glioma. We established transgenic zebrafish overexpressed dominant-active (DA) human Akt1 or Rac1G12V (DARac1) at ptf1a domain and investigated phenotypes mechanisms leading Transgene expressions were spatiotemporally restricted without any developmental abnormality embryos persisted cerebellum medulla adult zebrafish. DAAkt1...
Chronic inflammation is associated with the pathogenesis of type 2 diabetes and diabetic complications, palmitate has been nominated as a candidate for molecular link between these disorders. Recently, crucial role ceramide in metabolic diseases reported. Therefore, this study, we investigated whether formation involved palmitate‑induced hepatic vitro vivo. Ceramide can be generated either by de novo pathway or sphingomyelin degradation, six different synthases (CerS) determine specific acyl...
Sarcopenia and obesity are emerging as major social problems. In this study, we examined whether
Abstract Background Ceramide, a bioactive signaling sphingolipid, has long been implicated in cancer. Members of the ceramide synthase (CerS) family determine acyl chain lengths ceramides, with 4 (CerS4) primarily generating C18–C20-ceramide. Although CerS4 is known to be overexpressed breast cancer, its role cancer pathogenesis not well established. Methods To investigate public datasets, including The Cancer Genome Atlas (TCGA) and two Gene Expression Omnibus (GEO) datasets (GSE115577...
The aims of this study were to identify the clinical significances size metastatic lymph node (mLN) and LN ratio (LNR) attempt create a risk stratification for papillary thyroid carcinoma (PTC) patients. We investigated 435 PTC patients who underwent radioactive iodine (RAI) ablation treatment following surgery. classified into two groups (micrometastasis (pN1mic) ≤ 0.2 cm macrometastasis (pN1mac) > cm) stratified three groups: group I (pN1mic, LNR 0.5); II 0.5 or pN1mac, III (pN1mac with...
In recent years, Korea has experienced a steadily declining birth rate, which is serious social problem in the country. Although living conditions have improved, rates for low weight infants and preterm babies increased because more women choose to give later life environment changed. The rise may increase infant mortality morbidity rates. However, improvements neonatal care elevated survival rate of up 90 percent lowered very that can now be saved. this study, we used dynamic population...
Key Clinical Message The case of an infant girl with severe congenital sideroblastic anemia associated a novel molecular defect in mitochondrial transporter SLC25A38 is presented. Her transfusion dependence was fully reversed following allogeneic hematopoietic stem cell transplantation using modified reduced‐intensity conditioning regimen, and she remains healthy 5 years posttransplant.
To determine whether baseline thyroid-stimulating immunoglobulin (TSI) bioassay or its early response upon treatment with an anti-thyroid drug (ATD) can predict prognosis of Graves' disease (GD) in real-world practice.This retrospective study enrolled GD patients who had previous ATD TSI checked at and follow-up from April 2010 to November 2019 one referral hospital. The population were divided into two groups: experienced relapse continued (relapse/persistence), no after discontinuation...
Thymomas are one of the most common neoplasms mediastinum derived from thymic epithelium. It is that invasive thymoma invades lung, pericardium, and great vessels. Airway compression by mass effect also occurs, but direct polypoid tumor growth into airway extremely rare. Only 20 cases with endobronchial have previously been reported globally. However, there no case report endotracheal growth. Herein, we a rare in 28-year-old woman. Keywords: Thymoma; Bronchoscopy
본 연구는 유아의 자기조절 및 어머니의 양육행동과 스마트기기 중독경향성이 과다이용에 미치는 영향을 파악하고자 하였다. 연구대상은 유아교육기관에 다니는 3~5세 유아들과 그들의 어머니 166명이었으며, 통계 방법으로는 빈도분석, 상관분석, 위계적 회귀분석을 실시하였다. 결과는 다음과 같다. 첫째, 이용 실태는 주 1~2회, 10~30분 정도, 주말에 가장 많이 이용하였다. 대부분 유아들은 3세 이전에 스마트기기를 이용하기 시작하였고, 부모를 통해 접근하였으며, 형제 자매와 주로 함께 규칙이 있는 경우는 66.3%였고, 자녀의 재미와 흥미를 위해 이용하게 둘째, 변인들 간의 상관관계에서 중독경향성, 과보호 허용과 과다이용이 정적으로 관련이 있었으며, 온정 격려, 한계설정, 자기조절과는 부적인 상관이 있었다. 있어서 영향력 변인으로 밝혀졌다. 연구 유아들의 이용에 대한 가이드라인을 제공하기 위한 방안을 모색하고 유아를 올바른 방향을 설정하는 기초 자료로 활용되는데 그 의의를 찾을...
This paper reports the results of a hospital centered follow-up program on parenting stress, efficacy and coping for mothers with very low birth weight (VLBW) infants.The consisted home visiting by an expert group self-help 1 year. A non-equivalent control pre-post quasi-experimental design was used. Participants were 70 infants assigned to one two groups, experimental groups (n=28), which received family support program; (n=27), usual discharge education. Data analyzed using χ²-test,...
The burden of nonalcoholic fatty liver disease is increasing, and limited therapeutic drugs are available for its treatment. Serotonin binds to approximately 14 serotonin receptors (HTR) plays diverse roles in obesity metabolic complications. In this study, we focused on the function HTR4 using GR113808, a selective antagonist. Male C57BL/6J mice were fed high-fat diet 12 weeks with intraperitoneal GR113808 injection, HTR expression, weight changes, glucose lipid metabolism, hepatic fat...
To date, no study has reported the various otologic conditions associated with COVID-19 using population-based design. The aim of this was to investigate incidence and risk audio-vestibular disorders (benign paroxysmal positional vertigo, sudden sensorineural hearing loss, Meniere's disease, vestibular neuritis, tinnitus) increase after infection.
Thyroid hormone (TH) has a pivotal role in skeletal development, linear growth and maintenance of adult bone mass. Additionally, there are several studies which supported the direct effect thyroid-stimulating (TSH) on metabolism. As thyroid disease is one most common endocrine problems, clinical impact dysfunction metabolism been elucidated various studies. Hyperthyroidism associated with excessive loss mass an increased life-time risk for fractures. Adverse effects hyperthyroidism distinct...
Abstract BACKGROUND: BRAF V600E is the most common genetic alteration in thyroid cancer. However, there still controversy regarding its clinicopathological significance and clonal mutation frequency. To clarify these inconsistent results, we investigated association between allelic frequency of features classic papillary carcinoma (PTC). DESIGN: Tumor tissues from 321 patients with PTC were microdissected under a dissecting microscope analyzed for presence or absence mutant percentage using...
Parenting needs to be approached by cultural and economic aspects. Our society has become disordered because of the conflicts multicultural values caused dramatically developing economy. Between generations there are differences ideas many things, which marriage, diet, daily living, even relationships with others. In old days, children were used learn these through their extended family. It did not need said or shared, but acquired just naturally. We, however, live in a concept parenting is...