A5015000443- Sphingolipid Metabolism and Signaling
- Mesenchymal stem cell research
- Acute Myeloid Leukemia Research
- Catalytic Processes in Materials Science
- Catalysts for Methane Reforming
- Erythrocyte Function and Pathophysiology
- Soft Robotics and Applications
- Chronic Lymphocytic Leukemia Research
- Hepatitis B Virus Studies
- Metabolism and Genetic Disorders
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Endoplasmic Reticulum Stress and Disease
- Lipid Membrane Structure and Behavior
- Lysosomal Storage Disorders Research
- Hepatitis C virus research
- Calcium Carbonate Crystallization and Inhibition
- Lymphoma Diagnosis and Treatment
- Virus-based gene therapy research
- Silicon Carbide Semiconductor Technologies
- Blood groups and transfusion
- Micro and Nano Robotics
- Biosensors and Analytical Detection
- RNA regulation and disease
- Pancreatic function and diabetes
Ewha Womans University
2015-2024
Colorado State University
2024
Daegu Gyeongbuk Institute of Science and Technology
2019-2024
Dankook University Hospital
2009-2023
Eulji University
2023
Dankook University
2005-2022
Inha University Hospital
2022
Yonsei University
2022
Ewha Womans University Medical Center
2018
Weizmann Institute of Science
2012-2015
The endoplasmic reticulum (ER) is not only important for protein synthesis and folding but also crucial lipid metabolism. In the current study, we demonstrate an role of ceramide synthases (CerS) in ER stress NAFLD progression. Ceramide sphingolipid metabolism, its acyl chain length determined by a family six CerS mammals. CerS2 generates C22-C24 ceramides, CerS5 or CerS6 produces C16 ceramide. To gain insight into NAFLD, used high-fat diet (HFD)-induced mouse model. Decreased levels...
Ceramide is a key intermediate in the pathway of sphingolipid biosynthesis and an important intracellular messenger. We recently generated ceramide synthase 2 (CerS2) null mouse that cannot synthesize very long acyl chain (C22-C24) ceramides. This displays severe progressive hepatopathy. Significant changes were observed profile CerS2 liver, including elevated C16-ceramide sphinganine levels liver isolated mitochondrial fractions. Because may be involved reactive oxygen species (ROS)...
Sphingolipids are important structural components of cell membranes and act as critical regulators function by modulating intracellular signaling pathways. Specific sphingolipids, such ceramide, glucosylceramide, ganglioside GM3, have been implicated in various aspects insulin resistance, because they shown to modify several steps the pathway, phosphorylation either protein kinase B (Akt) or receptor. We now explore role ceramide acyl chain length using a synthase 2 (CerS2) null mouse, which...
Chronic ethanol consumption is known as an independent risk factor for type 2 diabetes, which characterized by impaired glucose homeostasis and insulin resistance; however, there a great deal of controversy concerning the relationships between alcohol development diabetes. We investigated effects chronic on pancreatic β-cell dysfunction whether generated peroxynitrite participates in homeostasis. Here we show that feeding decreases ability β-cells to mediate secretion ATP production...
Schwann cells (SCs), which produce neurotropic factors and adhesive molecules, have been reported previously to contribute structural support guidance during axonal regeneration; therefore, they are potentially a crucial target in the restoration of injured nervous tissues. Autologous SC transplantation has performed shown promising clinical results for treating nerve injuries donor site morbidity, insufficient production considered as major issue. Here, we differentiation tonsil-derived...
Fabry disease is a lysosomal storage disorder caused by deficiency of alpha-galactosidase A (α-gal A), which results in the deposition globotriaosylceramide (Gb3) vascular endothelium. Globotriaosylsphingosine (lyso-Gb3), deacylated Gb3, also increased plasma patients with disease. Renal fibrosis key feature advanced patients. Therefore, we evaluated association Gb3 and lyso-Gb3 accumulation epithelial–mesenchymal transition (EMT) on tubular epithelial cells kidney. In HK2 cells, exogenous...
X-linked hypophosphatemic rickets (XLH) results from mutations in the PHEX gene. Mutational analysis of gene 15 unrelated Korean patients with revealed eight mutations, including five novel nine patients: two nonsense missense one insertion, and three splicing acceptor/donor site mutations. Of these, c.64G>T, c.1699C>T, c.466_467 insAC, c.1174-1G>A, c.1768+5G>A were To analyze correlation between genotype phenotype, phenotypes compared groups without a mutation, terms mutation location,...
Very long chain (C22-C24) ceramides are synthesized by ceramide synthase 2 (CerS2). A CerS2 null mouse displays hepatopathy because of depletion C22-C24 ceramides, elevation C16-ceramide, and/or sphinganine. Unexpectedly, mice were resistant to acetaminophen-induced hepatotoxicity. Although there a number biochemical changes in the liver, such as increased levels glutathione and multiple drug-resistant protein 4, these effects unlikely account for lack acetaminophen toxicity. other...
Reactive oxygen species (ROS) generated by neutrophils provide a frontline defence against invading pathogens. We investigated the supportive effect of tonsil-derived mesenchymal stem cells (TMSCs) on ROS generation from using promyelocytic HL-60 cells. Methods: Differentiated (dHL-60) were cocultured with TMSCs isolated 25 independent donors, and in dHL-60 was measured luminescence. RNA sequencing real-time PCR performed to identify candidate genes involved augmenting oxidative burst...
To enhance the early strength of grounded granulated blast furnace slag (GGBFS) blended cement, activation characteristics GGBFS were examined by a potassium aluminum sulfate (PSA) clinker, consisting KAl(SO4)2 and amorphous Al2O3 calcining alunite [K2SO4·Al2(SO4)3·4Al(OH)3] at 650°C for 30 min. The PSA clinker reacted with calcium hydroxide gypsum to form ettringite (3CaO·Al2O3·3CaSO4·32H2O, AFt) following reaction:...
In this paper, we developed Deep Trench structure of LDMOS instead STI in conventional one, with 0.18um 60V BCD process. By forming vertical drift region using Trench, achieved lower Ron.sp from cell pitch shrink while BVdss does not change. As a result 76V and 49.3 mohm*mm2 low side rated LDNMOS.
In this study, we evaluated the analytical performance and clinical potential of a one-step multiplex real-time PCR assay for simultaneous detection 14 types respiratory viruses using AdvanSure RV Kit (LG Life Sciences, Korea).Three hundred twenty specimens were tested with conventional reverse transcription (RT)-PCR assay. The results analyzed was compared RT-PCR respect to sensitivity specificity viruses.The limit (LOD) 1.31 plaque-forming units (PFU)/mL human rhinoviruses (hRVs), 4.93...
Acute liver failure, i.e., the fatal deterioration of function, is most common indication that emergency transplantation necessary. Moreover, in USA, drug-induced injury (DILI), including acetaminophen (APAP)-induced hepatotoxicity, main cause acute failure. Matching a donor for extremely difficult, and thus development novel therapy DILI urgently needed. Following recent approval by FDA proteasomal inhibitor bortezomib, its therapeutic effects on various human diseases, solid hematologic...